A5100462387- Mast cells and histamine
- Urticaria and Related Conditions
- Fungal Infections and Studies
- Mycobacterium research and diagnosis
- Plant Pathogens and Fungal Diseases
- Corneal Surgery and Treatments
- Prenatal Screening and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytokine Signaling Pathways and Interactions
- Tumors and Oncological Cases
- Vascular Malformations and Hemangiomas
- Bone and Dental Protein Studies
- Dermatologic Treatments and Research
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Mycology
- Acute Lymphoblastic Leukemia research
- Facial Rejuvenation and Surgery Techniques
- Autoimmune Bullous Skin Diseases
- Mesenchymal stem cell research
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Genomics and Chromatin Dynamics
Second Affiliated Hospital of Jilin University
2019-2024
Nanchang University
2021
University of Amsterdam
2019
Amsterdam UMC Location University of Amsterdam
2019
Amsterdam University Medical Centers
2019
Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal may hamper function. Ibrutinib an irreversible inhibitor of Bruton's tyrosine kinase (Btk), key signaling protein controlling the activation various immune cells, including macrophages neutrophils. The aim this study was to determine whether ibrutinib treatment ameliorates acute pneumonia. Mice were treated orally with effect on pulmonary elicited...
Abstract Chronic idiopathic urticaria (CIU) is a polyetiological dermatologic disease. Reports have stated that some microRNAs (miRNAs) their roles to play in inflammatory response. In this present study, we aim investigate whether miR‐194 has an effect on attenuating response and human dermal microvascular endothelial cells (HDMECs) permeability of CIU mast through TGF‐β/SMAD pathway by binding thrombospondin 1 (THBS1). The Gene Expression Omnibus database was used obtain the CIU‐related...
This study aimed to investigate the molecular mechanism of sporotrichosis and identify possible novel therapeutic targets. Total RNA was extracted from skin lesion samples patients used construct a long-chain transcriptome library miRNA for whole sequencing. The differentially expressed genes (DEGs) between groups were identified, then Gene Ontology, Kyoto Encyclopedia Genes Genomes, Set Enrichment Analysis enrichment analyses performed based on DEGs. An lncRNA-miRNA-mRNA ceRNA network...
In this study, we aimed to decipher the impact of enhancer zeste homolog 2 (EZH2) in psoriasis as well underlying mechanism.A mouse model was developed by means imiquimod induction, with expression EZH2, microRNA-125a-5p (miR-125a-5p), and SFMBT1 determined. The role miR-125a-5p, malignant phenotypes HaCaT cells development vivo subsequently investigated through gain- loss-of-function experiments. Chromatin immunoprecipitation assay dual-luciferase reporter were conducted explore...
As a significant chromosomal structural abnormality, inversion is closely related to male infertility. For carriers, the interchromosomal effect explains infertility, but its specific mechanism remains unclear. Additionally, carriers with different chromosomes have clinical manifestations. Therefore, genetic counseling difficult in practice. Herein, four of pericentric chromosome 6 been described. Two patients showed asthenospermia, one azoospermia, and wife remaining patient had recurrent...
Infantile hemangiomas (IHs) are the most common childhood benign tumors, showing distinctive progression characteristics and outcomes. Due to high demand for aesthetics among parents of IH babies, early intervention is critical in some cases. β-Adrenergic blockers corticosteroids first-line medications IHs, while itraconazole, an antifungal medicine, has shown positive results recent years.In present study, itraconazole was applied treat two The therapeutic course lasted 80-90 d, during...
In recent years, stem cells have been studied for treating tooth loss. The present study aimed to investigate the roles of dentin non-collagen protein (DNCP)-associated microenvironments in differentiation induced pluripotent (iPSCs) into cells. iPSCs were cultured and identified by examining octamer-binding transcription-factor-4 (Oct-4) sex-determining region-Y-2 (Sox-2) expression. differentiated culturing DNCP-associated (containing specific growth factors), they divided control, DNCP,...