A5088588572- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Biochemical and Structural Characterization
- Advanced Thermodynamic Systems and Engines
- Congenital Anomalies and Fetal Surgery
- Hepatitis Viruses Studies and Epidemiology
- Escherichia coli research studies
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
- Enzyme Production and Characterization
- Digestive system and related health
- Biomedical and Engineering Education
- Gut microbiota and health
Universitat de València
2020-2025
Instituto de Agroquímica y Tecnología de Alimentos
2019
Lactobacillus casei and rhamnosus proteins P40 P75 belong to a large family of secreted cell wall that contain carboxy(C)-terminal CHAP or NlpC/P60 superfamily domains. In addition their peptidoglycan hydrolases activity, in this are specific antigens pathogens, frequently responsible interactions with the host. L. GG BL23 purified have antiapoptotic activity by inducing EGF/Akt pathway. The aim work was study genetics, phylogeny dissemination genus as well characteristics likely function....
Viral infections, particularly human norovirus (NoV), are a leading cause of diarrheal diseases globally. To better understand NoV susceptibility, it is crucial to investigate both host glycobiology and the influence microbiota. Histo-blood group antigens (HBGA) displayed on surfaces cells act as receptors, while certain bacteria express HBGA-like substances, facilitating virus-bacteria interactions. identify bacterial species interacting with during infection, stool samples from children...
Rotaviruses (RVs) are the main cause of viral diarrhea among infants, small children, and young many animal species. Histo-blood group antigens (HBGAs) potential RV receptors glycan composition on mucous surfaces influences host susceptibility cross-species virus transmission. RVs exhibit genotype-dependent binding differences due to sequence modifications in VP8* domain spike protein VP4. Nevertheless, molecular bases for this specificity, especially non-A RVs, not thoroughly understood....
Sapovirus is a common cause of acute gastroenteritis in all age groups. infections are seldom investigated Spain, and its epidemiology the country not well known. The use molecular diagnostic procedures has allowed more frequent detection sapoviruses patients with diarrhea. A total 2545 stool samples from attended June 2018 to February 2020 at Clinic University Hospital Valencia, were analyzed by reverse transcription (RT) real-time multiplex PCR (RT-PCR) investigate etiology enteric...
Noroviruses are the leading cause of sporadic cases and outbreaks viral gastroenteritis. For more than 20 years, most norovirus infections have been caused by pandemic genotype GII.4, yet recent studies reported emergence recombinant strains in many countries. In present study, 4,950 stool samples collected between January 2016 April 2020 Valencia, Spain, from patients with acute gastroenteritis were analyzed to investigate etiological agent. Norovirus was frequently detected enteric virus,...
Rotavirus (RV) is the leading cause of acute gastroenteritis (AGE) in children under 5 years old worldwide, and several studies have demonstrated that histo–blood group antigens (HBGAs) play a role its infection process. In present study, human stool filtrates from patients diagnosed with RV diarrhea (genotyped as P[8]) were used to infect differentiated Caco-2 cells (dCaco-2) determine whether such viral strains clinical origin had ability replicate cell cultures displaying HBGAs. The...
Rotavirus remains a significant public health threat, especially in low-income countries, where it is the leading cause of severe acute childhood gastroenteritis, contributing to over 128,500 deaths annually. Although introduction Rotarix and RotaTeq vaccines 2006 marked milestone reducing mortality rates, approximately 83,158 preventable persisted, showing ongoing challenges vaccine accessibility effectiveness. To address these issues, novel subcutaneous formulation targeting multiple...
Human noroviruses (HuNoVs) are the main cause of acute gastroenteritis causing more than 50,000 deaths per year. Recent evidence shows that gut microbiota plays a key role in enteric virus infectivity. In this context, we tested whether depletion or replacement with human individuals susceptible to HuNoVs infection could favor viral replication mice. Four groups mice (n = 5) were used, including control group and three treated antibiotics eliminate autochthonous intestinal microbiota. Two...
Abstract The aims of the present work were to determine prevalence and titer serum antibodies against several rotavirus VP8* proteins from different P genotypes in children adults Valencia, Spain; role secretor status (FUT2 G428A polymorphism) antibody response. protein P[4], P[6], P[8], P[9], P[11], P[14] P[25] produced E. coli . These tested with 88 samples (n = 41, 3.5 years old average) 47, 58 by ELISA. A subset 55 genotyped for FUT2 polymorphism titers compared. same was also analysed...
Mutualistic bacteria have different forms of interaction with the host. In contrast to invasion pathogenic bacteria, naturally occurring internalization commensal has not been studied in depth. Three vitro methods, gentamicin protection, flow cytometry and confocal laser scanning microscopy, implemented accurately assess two lactobacillus strains-Lacticaseibacillus paracasei BL23 Lacticaseibacillus rhamnosus GG-in Caco-2 T84 intestinal epithelial cells (IECs) under a variety physiological...
ABSTRACT Noroviruses are the leading cause of sporadic cases and outbreaks viral gastroenteritis. For more than 20 years most norovirus infections have been caused by pandemic genotype GII.4, yet recent studies reported emergence recombinant strains in many countries. In present study, 4,950 stool samples collected between January 2016 April 2020 Valencia (Spain) from patients with acute gastroenteritis were analyzed to investigate etiological agent. Norovirus was frequently detected enteric...