A5001165412- Advanced Polymer Synthesis and Characterization
- Covalent Organic Framework Applications
- Cancer Immunotherapy and Biomarkers
- biodegradable polymer synthesis and properties
- Polymer Nanocomposites and Properties
- Single-cell and spatial transcriptomics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Photocatalysis Techniques
- MicroRNA in disease regulation
- Immune cells in cancer
- Botanical Research and Chemistry
- Circular RNAs in diseases
- Engineering Technology and Methodologies
- Phase Change Materials Research
- Proteins in Food Systems
- Photopolymerization techniques and applications
- Recycling and Waste Management Techniques
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Multiple Myeloma Research and Treatments
- Hydrogels: synthesis, properties, applications
- Advanced Thermoelectric Materials and Devices
- Cancer Mechanisms and Therapy
- Adsorption and Cooling Systems
Hebei University of Science and Technology
2010-2024
First People's Hospital of Foshan
2020-2023
Max Planck Institute for Multidisciplinary Sciences
2023
Zhejiang University
2008-2022
Fourth Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
West China Hospital of Sichuan University
2022
Sichuan University
2022
First Hospital of Shijiazhuang
2022
China Institute of Veterinary Drug Control
2021
Although the outcome of colorectal cancer (CRC) patients has improved significantly with recent implementation annual screening programs, reliable prognostic biomarkers are still needed due to disease heterogeneity. Increasing pieces evidence revealed an association between immune signature and CRC prognosis. Thus, we aim build a robust immune-related gene pairs (IRGPs) that can estimate prognosis for CRC. Gene expression profiles clinical information were collected from six public cohorts,...
A series of gradient copolymers methacrylic acid (MAA)/methyl methacrylate (MMA) with four end-to-end composition profiles (uniform, linear gradient, triblock midblock, and diblock) but all having an average chain ̅F(MMA) ≈ 0.5 length 200 were synthesized via model-based, computer-programmed, semibatch atom-transfer radical copolymerization (ATRcoP). These samples allowed us to investigate systematically the effects profile on pH responsivity micelle formation in aqueous solution....
Abstract Methyl methacrylate (MMA)/ tert ‐butyl ( t BMA) gradient copolymers having linear and hyperbolic composition profiles were synthesized. These special copolymer products achieved via a model‐based computer‐controlled semibatch atom transfer radical copolymerization (ATRcoP) process. A simple ATRcoP model was developed based on the terminal model. The equilibrium constants in ATRP of MMA BMA estimated by data correlation. verified batch experiments found to give good correlation for...
Abstract Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO remained obscure. Here, we provide transcriptional hippocampal profiling male mice treated with rhEPO. Based on ~108,000 single nuclei, unmask multiple pyramidal lineages their comprehensive molecular signatures. By temporal gene regulatory analysis, build developmental trajectory CA1 neurons derived from...
Understanding immune cell phenotypes in the tumor microenvironment (TME) is essential for explaining and predicting progression of non-small lung cancer (NSCLC) its response to immunotherapy. Here we describe single-cell transcriptomics CD45 + cells from tumors, normal tissues blood NSCLC patients. We identified three clusters exerting immunosuppressive effects: CD8 T with exhausted phenotype, tumor-associated macrophages (TAMs) a pro-inflammatory M2 regulatory B (B regs) tumor-promoting...
We studied the crystallization of nearly "homogeneous" polyethylene glycol (PEG) networks prepared by end-crosslinking tetra-armed PEG. The influence stretching ratio and strand length on melting temperature was investigated. relation elongation verifies thermodynamic theories strain-induced polymer crystallization.
Abstract Polyphenylene oxide (PPO) was prepared via oxidative coupling polymerization of 2,6‐dimethylphenol (DMP) catalyzed by copper salt. The ligand a novel series random copolymers (PSVP) styrene and 4‐vinylpyridine reversible addition‐fragmentation chain transfer (RAFT) copolymerization. with well‐controlled molecular weight (MW) were used to study the effects on catalytic activity selectivity. It found that increased but there existed an upper MW limit above which no further increase in...
Older patients with acute myeloid leukemia (AML) face a higher risk of death. This study analyzed the gene sequencing results an elderly AML patient to provide new ideas for treatment.This performed single-cell RNA (scRNA-seq) bioinformatics analysis blood cells in peripheral and bone marrow 64-year-old AML-M5 before chemotherapy. The differentially expressed genes (DEGs) were identified, functional enrichment analyses performed.A total 7990 123 DEGs identified monocytes hematopoietic stem...
Nasopharyngeal carcinoma (NPC), which is a form of cancer arising from the epithelium nasopharynx, remains highly prevalent, particularly in Southeast Asia and Southern China. Dysregulated long non-coding RNAs (lncRNAs) are involved several malignancies, including growth aggression tumors. LncRNA IGBP1-AS1 plays an important role advancement breast cancer, but its NPC has not yet been explored.LncRNA levels human samples compared with their matched adjacent normal tissues by quantitative...
Abstract Metal‐coordinated covalent organic frameworks (M‐COFs) have garnered significant attention for their potential in carbon dioxide (CO 2 ) photoreduction. However, the efficient conversion of CO to (carbon monoxide) remains challenging because strong exciton effects from Coulombic interactions electron‐hole pairs within metal‐associated coordination environment. Herein, three benzoxazole (BBO)‐based COF photocatalysts coordinated with cobalt (Co) ions featuring distinct geometries:...
Abstract Background Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes.Methods performed a multicenter retrospective analysis of data from 773 patients across 9 centers China 2006 to 2019. Sociodemographic and clinical treatment regimens were recorded, univariate multivariate analyses performed. Results Overall, 69.21% had low levels. Patients with levels...
Data from single-cell RNA sequencing (RNA-seq) of CLL patients were obtained the Gene Expression Omnibus database. The R package was utilized to analyze data, and relation results predicted via GeneMANIA website. information 7 samples covered three stages: observation stage, pretreatment by CIT with rituximab, fludarabine, cyclophosphamide (pre-CIT), post-CIT. differentially expressed genes (DEGs) identified, functional enrichment analyses performed. B cell subpopulations pseudotime...
ABSTRACT Recombinant human erythropoietin (rhEPO) has potent procognitive effects, hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO have remained obscure. Here, we provide encyclopedic transcriptional hippocampal profiling mice treated with rhEPO. Based on ∼108,000 single nuclei, unmask multiple pyramidal lineages their comprehensive molecular signatures. By temporal gene regulatory analysis, build a developmental trajectory CA1 neurons...
In this article, the graft copolymerization of 4-vinyl pyridine onto poly (ethylene terephthalate)(PET) via potassium diperiodacuprate(III)–PET redox system as an initiator was investigated in alkaline medium. The copolymer characterized with Fourier-transform infrared spectra analysis. A mechanism is proposed to explain generation radicals and initiation. effects reaction variables, such concentration, ratio monomer PET, pH, temperature time, are investigated, grafting conditions optimized....
Abstract Two latex interpenetrating polymer networks (LIPNs) were synthesized with methyl methacrylate (MMA) and octyl acrylate (OA) as monomers, respectively. The apparent kinetics of polymerization for the LIPNs was studied. This demonstrates that network II does not have a nucleus formation stage. monomers diffused into particles I then formed by in situ polymerization. It indicates obeys classical kinetic rules emulsion But only appears constant‐rate stage decreasing‐rate activation...
Objective To analyze the factors affecting turnaround time (TAT) in tumor marker detection, and to observe effect of continuous improvement measures such as optimizing detection process on shortening TAT. Methods TAT related data pre-optimized markers were collected by Laboratory Information Management System (LIS). The reasons key nodes for extension TAT analyzed. A series taken, strengthening training all working staff, increasing frequency, test process. Before after times...