A5090085669- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Ocular Surface and Contact Lens
- Parkinson's Disease Mechanisms and Treatments
- Connexins and lens biology
- Drug Solubulity and Delivery Systems
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Intraocular Surgery and Lenses
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Psidium guajava Extracts and Applications
- Biotin and Related Studies
- Barrier Structure and Function Studies
- Traditional and Medicinal Uses of Annonaceae
- Food Science and Nutritional Studies
- Animal testing and alternatives
- Hydrogels: synthesis, properties, applications
- Phytochemicals and Antioxidant Activities
- Retinopathy of Prematurity Studies
- Global Healthcare and Medical Tourism
- Circadian rhythm and melatonin
- Phytochemicals and Medicinal Plants
- Biochemical and Structural Characterization
Central Institute of Medicinal and Aromatic Plants
2022-2024
Birla Institute of Technology and Science, Pilani
2021
Birla Institute of Technology and Science - Hyderabad Campus
2020
University of Auckland
2016-2017
Cancer Society of New Zealand
2017
Indo Soviet Friendship College of Pharmacy
2014-2016
Institute of Biomedical Science
2013
Topical drug administration for back of the eye delivery is extremely challenging due to presence protection mechanisms and physiological barriers. Self-assembled polymeric nanomicelles have emerged as promising vehicles delivery. Apart from serving an inert nanocarrier therapeutic agents, are known bypass mononuclear phagocytic system (MPS) efflux transporters thereby improving bioavailability. In this investigation, a highly efficacious biotinylated lipid prodrug cyclic cidofovir...
Introduction: Tardive dyskinesia is a serious motor disorder of the orofacial region, resulting from chronic neuroleptic treatment schizophrenia. Candesartan (AT1 antagonist) and lisinopril (ACE inhibitor) has been reported to possess antioxidant neuroprotective effects. The present study designed investigate effect candesartan on haloperidol-induced oxidative damage in rats. Materials methods: was induced by administering haloperidol (1 mg/kg i.p.) concomitantly treated with (3 5 p.o.) (10...
Animal experimentation has been integral to drug discovery and development safety assessment for many years, since it provides insights into the mechanisms of efficacy toxicity (e.g. pharmacology, pharmacokinetics pharmacodynamics). However, due species differences in physiology, metabolism sensitivity drugs, animal models can often fail replicate effects drugs chemicals human patients, workers consumers. Researchers across globe are increasingly applying Three Rs principles by employing...
Frequent intravitreal injections are currently used to overcome the ocular barriers and provide sufficient drug posterior eye segment. However, have been associated with a number of complications high treatment costs. To these limitations, peptide-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs) were developed using nanoprecipitation technique optimized via Box-Behnken Design (BBD) Response Surface Methodology (RSM). Developed NPs evaluated for potential toxicity cell...
The phytochemical investigation of Psidium guajava leaves led to the isolation total nineteen compounds which belongs meroterpenoids, flavonoid, phenolics, and triterpenoids. were isolated using extensive chromatography techniques identified as psiguanol (4), new compound along with guajadial (1), psidial A (2), β-caryophyllene (3), quercetin (5), avicularin (6), guaijaverin (7), hyperin (8), rutin (9), ursolic acid (10), corosolic (11), asiatic (12), β-sitosterol (13),...
Connexin43 mimetic peptide (Cx43MP) has been intensively investigated for its therapeutic effect in the management of inflammatory eye conditions, spinal cord injury, wound healing and ischemia-induced brain damage. Here, we report on a validated stability-indicating reversed-phase high performance liquid chromatography (RP-HPLC) method quantification Cx43MP under stress conditions. These included exposure to acid/base, light, oxidation temperature. In addition, degradation kinetics were...
Summary Retinal diseases are currently treated by frequent injections of a drug‐containing solution into the eye, an unpleasant procedure that may lead to complications and low treatment adherence. This has been partially addressed developing implants once sutured sclera or injected vitreous can release drug over months years. However, these in place, rates cannot be altered based on individual patient needs. Our research within Buchanan Ocular Therapeutics Unit aims develop...