A5013142376- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
- Fibroblast Growth Factor Research
- Trace Elements in Health
- Therapeutic Uses of Natural Elements
- Nutrition and Health in Aging
- Kruppel-like factors research
- Genetic Syndromes and Imprinting
- Bone health and osteoporosis research
- Alcoholism and Thiamine Deficiency
- Connective Tissue Growth Factor Research
- Electrolyte and hormonal disorders
- Folate and B Vitamins Research
- Vitamin K Research Studies
- Hemoglobinopathies and Related Disorders
- Pancreatitis Pathology and Treatment
- Bone health and treatments
- Vitamin D Research Studies
- Iron Metabolism and Disorders
- Vitamin C and Antioxidants Research
University of Córdoba
2020-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2020-2024
Institute for Research in Biomedicine
2023-2024
Instituto de Salud Carlos III
2020
Instituto de Biomedicina de Sevilla
2020
Universidad de Sevilla
2020
Hospital Universitario Virgen del Rocío
2020
Hospital Universitario Reina Sofía
2020
Inflammation is a common feature in chronic kidney disease (CKD) that appears specifically associated with cardiovascular derangements CKD patients. Observational studies have revealed link between low Mg levels and inflammation. In this study, we hypothesize might modulatory effect on the inflammation induced under uraemic milieu.In vivo were performed 5/6 nephrectomized rat model of CKD. Furthermore, possible direct was addressed through vitro vascular smooth muscle cells (VSMCs).Uraemic...
Abstract Fibroblast growth factor 23 (FGF23) increases phosphorus excretion and decreases calcitriol (1,25(OH)2D) levels. FGF23 from early stages of renal failure. We evaluated whether strict control intake in failure prevents the increase to what extent inflammation impairs regulation FGF23. The study was performed 5/6 nephrectomized (Nx) Wistar rats fed diets containing 0.2–1.2% for 3 or 15 days. levels significantly increased all Nx groups short-term (3-day) experiment. However, at days,...
Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular (CVD) in these patients Mg concentration is usually decreased. This study evaluated whether a dietary supplementation might attenuate vascular dysfunction through the modulation of oxidative stress inflammation concurrent MetS CKD.A rat model (Zucker strain) CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed normal 0.1%Mg (MetS+Nx+Mg0.1%) or supplemented 0.6%Mg...
ABSTRACT Background In chronic kidney disease (CKD) patients, increased levels of fibroblast growth factor 23 (FGF23) are associated with cardiovascular mortality. The relationship between FGF23 and heart hypertrophy has been documented, however, it is not known whether an effect on vasculature. Vascular smooth muscle cells VSMCs may exhibit different phenotypes; our hypothesis that favours a switch from contractile to synthetic phenotype cause vascular dysfunction. Our objective was...
The progression of chronic kidney disease (CKD) involves the development alterations in mineral metabolism that are closely related to cardiovascular outcomes and bone disease. Hypomagnesemia is associated with more rapid CKD other comorbidities. Our objective was analyze patients stages 3–4 impact administration magnesium (Mg) carbonate on density (BMD) hemodynamic changes by vascular calcification (VC). Patients were randomized into controls (n = 12) or intervention 7) group receiving 360...
The progression of chronic kidney disease (CKD) involves the development alterations in mineral metabolism that are closely related to cardiovascular outcomes and bone disease. Hypomagnesemia is associated with more rapid CKD other comorbidities. Our objective was analyze patients stages 3-4 impact administration magnesium (Mg) carbonate on density (BMD) hemodynamic changes by vascular calcification (VC).
In chronic kidney disease (CKD) patients, it would be desirable to reduce the intake of inorganic phosphate (P) rather than limit P contained in proteins. Urinary excretion should reflect intestinal absorption P(inorganic plus protein-derived). The aim present study is determine whether ratio urinary urea nitrogen (P/UUN ratio) helps identify patients with a high P.A cross-sectional was performed 71 affected by metabolic syndrome CKD (stages 2–3) normal serum concentration. A 3-day dietary...
Abstract Background and Aims The physiological function of sclerostin (SOST) remains unknown. It is known that SOST produced in osteocytes functions as an inhibitor the Wnt/β-catenin pathway. Similarly, it well-established low levels lead to bone alterations affecting cortical bone, resulting osteopetrosis reduced calciuria. High are associated with osteoporosis. In this study, we aimed investigate impact three elevated doses on cortical, trabecular, subchondral well its relationship other...
Abstract Background and Objectives Ongoing studies are shedding light on the potential connection between FGF23 hypertension. In experimental settings, administration of recombinant in mice has been demonstrated to induce hypertension by elevating serum sodium, along with an increase NCC receptors kidney. Clinical evidences further supports pro-hypertensive effects high circulating levels FGF23. Our group previously a direct influence increased arterial stiffness inducing phenotypic...
Calcitriol and calcimimetics are used to treat hyperparathyroidism secondary chronic kidney disease (CKD). administration the subsequent increase in serum calcium concentration decrease parathyroid hormone (PTH) levels, which should reduce bone remodeling. We have previously reported that, when maintaining a given of PTH, addition is associated with an increased cell activity. Whether calcitriol affects activity while PTH maintained constant be evaluated animal model renal osteodystrophy....
Because angiotensin (Ang) II is an essential vasoconstrictive peptide, we analyzed the impact of its post-translational modification to pyruvamide-Ang (Ang P) by pyridoxal-5'-phosphate (PLP) on blood pressure. PLP a less expensive vitamin B
Abstract Background and Aims In chronic kidney disease (CKD) patients, phosphate (P) restriction is crucial for the control of mineral metabolism. Many reports indicate that P intake doesnot correlate with 24-hour phosphaturia. Different sources (organic or inorganic) have different intestinal absorption rates. proportions organic inorganic in diet might be reason lack correlation between phosphorus Therefore, we aimed to evaluate if source dietary rather than total amount ingested...
Abstract Background and Aims Iron (Fe) deficiency significantly contributes to anemia in chronic kidney disease (CKD). High FGF23 levels, commonly found CKD, are related adverse outcomes patients. In the normal setting, an association between Fe has been observed. However, it is unknown whether deficiency-induced might contribute excessive levels CKD. Thus, this study was intended evaluate interplay deficiency, FGF23. Method Male Wistar rats with renal function received either standard (40...
Abstract Background and Aims In chronic kidney disease (CKD) patients, high serum phosphate (HP) levels are associated with the development of a cardiorenal renal syndrome type 4 (CRS4). this syndrome, heart is damaged by oxidative stress, inflammation, fibrosis in tissue. study we have evaluated if dietary Mg supplementation could reduce CRS4. Method The vivo studies were performed 5/6Nx rats fed (0.9%) diet or low content to evaluate: 1) effect (0.3%) on inflammation heart. 2) contribution...
Abstract Background and Aims In patients with chronic kidney disease (CKD), high levels of c-terminal fibroblast growth factor 23 (FGF23) are associated cardiovascular mortality. Vascular smooth muscle cells (VSMC) may present two clearly differentiated functional phenotypes, contractile synthetic. The abundance synthetic phenotype is vascular dysfunction it unknown whether in FGF23 promote transition from a to VSMC causing stiffness. study was conducted evaluate affects arterial Method...