A5078832460- Oral microbiology and periodontitis research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Salivary Gland Disorders and Functions
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Microbial Natural Products and Biosynthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Oral and Maxillofacial Pathology
- Hematological disorders and diagnostics
- Antimicrobial Peptides and Activities
- Periodontal Regeneration and Treatments
- T-cell and Retrovirus Studies
- Fungal Biology and Applications
- Probiotics and Fermented Foods
- Bone and Dental Protein Studies
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Sulfur-Based Synthesis Techniques
- dental development and anomalies
- Complement system in diseases
- Cancer, Hypoxia, and Metabolism
Miwa Hospital
2015-2020
Kansai Medical University
2014
Municipal Hirakata City Hospital
2008-2012
Hoshigaoka Medical Center
1992-2007
Sakai Municipal Hospital
2005
Nihon University
1986-2003
Shionogi (Japan)
1968-2000
Yokufukai Hospital
1999
National Cancer Center Hospital East
1997
Kyoto Prefectural University of Medicine
1989
Although stem cell transplantation (SCT) is being used for hematopoietic reconstitution following high-dose chemotherapy malignancy, it involves certain serious transplant-related complications such as graft-versus-host disease (GVHD). Angiopoietins play important roles in angiogenesis. However, the role of angiopoietins after SCT poorly understood. In this study, 52 patients underwent SCT; 26 received allogeneic SCT, while remaining autologous SCT. 48 patients, levels angiopoietins,...
Three-dimensional substructure searching (3D search), using the program MACCS-3D, was utilized for designing novel angiotensin II receptor antagonists which contain a bioisostere of biphenylyltetrazole moiety DuP 753. A 3D query prepared from an overlay model substructures several potent AII antagonists. The search system retrieved 139 compounds database MDDR-3D, consisted 29,400 medicinal patent compounds. tricyclic compound selected and then evolved by considering steric fitness to...
A convenient synthetic method for the preparation of enantiomerically pure N-acylarylsulfonamides having an asymmetric center at α-position carbonyl group is described. Chiral phenylacetic acids are first converted to corresponding acid chlorides, which in turn condensed with arylsulfonamides presence powdered alkaline hydroxide CH2Cl2, giving good optical and chemical yields. more one-pot procedure also possible.
Conditioning regimens including total body irradiation (TBI) or cyclophosphamide can mobilize high-mobility group box 1 (HMGB1) to peripheral blood. Additionally, increased plasminogen activator inhibitor (PAI)-1 levels are associated with post-allogeneic hematopoietic stem cell transplantation (aHSCT). However, changes circulating of HMGB1 after aHSCT poorly understood.The study cohort included 289 patients who underwent at one 25 institutions in Japan. We have investigated the relationship...
We investigated the preventive effects of recombinant thrombomodulin (rTM) on Transplantation Associated Coagulopathy (TAC) and TAC-related biomarkers in 271 patients after hematopoietic stem cell transplantation (HSCT). There were no significant differences between rTM (+) or (-) groups patient background, types disease HSCT regimens. When we examined with confirmed complications, all frequencies aGVHD, VOD and/or TMA, as well uncomplicated cases significantly lower group. HMGB1 MCP-1...
We investigated the effects of early recombinant thrombomodulin (rTM) treatment on long-term prognosis after hematopoietic stem cell transplantation (HSCT). Subjects included 300 patients who underwent allogeneic HSCT (131 in rTM(+) group and 169 rTM(−) group). The control received heparin or no anti-coagulation therapy. When we examined with confirmed complications (day 1–100), frequencies acute graft-versus-host disease (aGVHD) thrombotic microangiopathy (TMA) were significantly lower...
This study measured and compared levels of some chemokines in patients with rituximab-treated non-Hodgkin lymphoma because they may participate the mechanism efficacy rituximab patients. Monocytic chemotactant protein-1, RANTES (regulated on activation, normally T-cell expressed secreted), eotaxin, interleukin-8, neutrophil-activating protein-78, stromal cell-derived factor-1, growth-regulating oncogene-alpha were by enzyme-linked immunosorbent assay. Levels higher than controls. monocytic...
Fomecins A and B, phenolic antibiotics produced by the basidiomycete Fomes juniperinus SCHRENK, asperugin, a metabolite of Aspergillus rugulosus, were synthesized from gallic acid. Various congeners also prepared. Their antibacterial antifungal activities tested in vitro some products found to exhibit moderate activities.
5(and 6)-Acyl-7, 8-dichloro-2, 3-dihydro-1, 4-benzodioxin-2-carboxylic acids (VI) and related compounds were synthesized tested for diuretic antihypertensive properties. These prepared by the reaction of 3, 4-dichloro-1, 2-dihydroxybenzene (2) with epibromohydrin (EBH) in presence a base Friedel-Crafts acylation, or acylation 2 EBH, followed oxidation. Acylation 7, 8-dichlorodihydrobenzodioxin-2-ylmethanol (15a) gave corresponding 5- 6-acyl compounds, (17 10). Diuretic activity was generally...
Prevotella nigrescens ATCC 25261 (P. nigrescens) cells adhere well to hydroxyapatite treated with citrate (CHA), but the attachment is drastically inhibited by lactoferrin (LF). To determine nature of iron-free LF responsible for inhibiting P. cell attachment, this study tested duration and frequency treatment CHA effects divalent trivalent ferric ions. The inhibitory effect on was somewhat higher bovine than human LF. Apo effectively CHA, almost abolished at a concentration 0.4 mg/ml. Fe3+...
A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-alpha]pyrimidine-3-carboxyli c acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an vitro binding assay using COS cells transfected with a cDNA encoding human AT1 receptor, the compounds this showed Ki values range 0.4-4.0 nM. In anesthetized spontaneously hypertensive rats (SHRs), administration 6-propyl derivative 4d (1 mg/kg, i.v.) reduced mean blood pressure (MBP) by maximum more than 30...