A5065777608- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Estrogen and related hormone effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Child and Animal Learning Development
- Nicotinic Acetylcholine Receptors Study
- Domain Adaptation and Few-Shot Learning
- Biochemical Analysis and Sensing Techniques
- Spatial Cognition and Navigation
- Cannabis and Cannabinoid Research
- Face Recognition and Perception
- Menopause: Health Impacts and Treatments
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Cognitive Functions and Memory
- Identity, Memory, and Therapy
- Multisensory perception and integration
University of Guelph
2014-2024
York University
2022-2024
Baycrest Hospital
2022-2024
Abstract Epigenetic mechanisms are increasingly acknowledged as major players in memory formation. Specifically, DNA methylation is necessary for the formation of long‐term various brain regions, including hippocampus ( HPC ); however, its role perirhinal cortex PR h), a structure critical object memory, has not been characterized. Moreover, mnemonic effects selective methyltransferase DNMT ) inhibition have yet investigated systematically, despite distinct roles de novo 3a, 3b) and...
Consolidated memories can become destabilized and open to modification upon retrieval. Destabilization is most reliably prompted when novel information present during memory reactivation. We hypothesized that the neurotransmitter acetylcholine (ACh) plays an important role in novelty-induced destabilization because of its established involvement new learning. Accordingly, we investigated effects cholinergic manipulations rats using object recognition paradigm requires reactivation novelty...
Abstract Histone variants H2A.Z and H3.3 are epigenetic regulators of memory, but roles other not well characterized. macroH2A (mH2A) is a structurally unique histone that contains globular macrodomain connected to the region by an unstructured linker. Here we assessed if mH2A regulates memory this role varies for two mH2A-encoding genes, H2afy (mH2A1) H2afy2 (mH2A2). We show fear impaired in mH2A1, mH2A2-deficient mice, whereas both groups were non-aversive spatial task. However, impairment...
The importance of histone acetylation for certain types memory is now well established. However, the specific contributions various acetyltransferases to distinct functions remain be determined; therefore, we employed selective acetyltransferase protein inhibitors and short-interference RNAs evaluate roles CREB-binding (CBP), E1A-binding (p300) p300/CBP-associated factor (PCAF) in hippocampus perirhinal cortex (PRh)-mediated object memory. Rats were tested short- (STM) long-term (LTM)...
Abstract Reactivated long-term memories can become labile and sensitive to modification. Memories in this destabilized state be weakened or strengthened, but there is limited research characterizing the mechanisms underlying retrieval-induced qualitative updates (i.e., information integration). We have previously implicated cholinergic transmission object memory destabilization. Here we present a novel rodent paradigm developed assess role of mechanism updating. The post-reactivation...
Abstract Evidence suggests that individual hippocampal subfields are preferentially involved in various memory‐related processes. Here, we demonstrated dissociations these memory processes two unique individuals with near‐selective bilateral damage within the hippocampus, affecting dentate gyrus (DG) case BL and cornu ammonis 1 ( CA1) subfield BR . was impaired discriminating highly similar objects (i.e., mnemonic discrimination) but exhibited preserved overall recognition of studied...
The hippocampus (HPC) is well-known for its involvement in declarative (consciously accessible) memory, but there evidence that it may also play a role complex perceptual discrimination. Separate research has demonstrated separable contributions of HPC subregions to component memory processes, with the dentate gyrus (DG) required mnemonic discrimination similar inputs and CA1 subfield retention retrieval, these processes understudied. current study examined nature extent double dissociation...
Acetylation of histone proteins by acetyltransferases (HATs), and the resultant change in gene expression, is a well-established mechanism necessary for long-term memory (LTM) consolidation, which not required short-term (STM). However, we previously demonstrated that HAT p300/CBP-associated factor (PCAF) also influences hippocampus (HPC)-dependent STM male rats. In addition to their epigenetic activity, HATs acetylate nonhistone involved nongenomic cellular processes, such as estrogen...
Abstract Reactivated long-term memories can become labile and sensitive to modification. Memories in this destabilized state be weakened or strengthened, but there is limited research characterizing the mechanisms underlying retrieval-induced qualitative updates (i.e., information integration). We have previously implicated cholinergic transmission object memory destabilization. Here we present a novel rodent paradigm developed assess role of mechanism updating. The post-reactivation...