A5037709673- Genetics, Aging, and Longevity in Model Organisms
- Ion channel regulation and function
- Colorectal Cancer Screening and Detection
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Ion Transport and Channel Regulation
- Cardiac electrophysiology and arrhythmias
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Neuroendocrine regulation and behavior
- Colorectal Cancer Surgical Treatments
- Plant Stress Responses and Tolerance
- Superconducting Materials and Applications
- Sensor Technology and Measurement Systems
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Obsessive-Compulsive Spectrum Disorders
- Particle accelerators and beam dynamics
- Plant Virus Research Studies
- Gastric Cancer Management and Outcomes
- Inflammatory mediators and NSAID effects
- Neuroscience and Neural Engineering
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
University of Miami
2015-2025
University of Miami Health System
2024
European Organization for Nuclear Research
2018-2021
University of Catania
2021
Institute of Electrical and Electronics Engineers
2021
University of Pisa
2021
Lawrence Berkeley National Laboratory
2021
Fermi National Accelerator Laboratory
2021
European Space Research and Technology Centre
2021
Imperial College London
2021
Journal Article THE FUNCTIONS OF FRONTAL LOBES Get access L. BIANCHI, M.D. Professor, and Director of the Clinique Mental Diseases, in University Naples Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 18, Issue 4, 1895, Pages 497–522, https://doi.org/10.1093/brain/18.4.497 Published: 01 October 1895
The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor (TfR), which mediates cellular uptake, is regulated by hypoxia. In Hep3B human hepatoma cells incubated in 1% O(2) or treated with CoCl(2), mimics hypoxia, we detected a 3-fold increase TfR mRNA despite decrease regulatory proteins activity. Increased resulted from 4-fold stimulation nuclear transcription rate gene both hypoxia CoCl(2). A role for hypoxia-inducible factor...
Ion Channel Mutations and Drug‐Induced TdP. The aim of this study was to test the hypothesis that some cases drug‐induced arrhythmias depend on genetic predisposition. Excessive prolongation QT interval life‐threatening (torsades de pointes or ventricular fibrillation) may occur in response a variety cardiac noncardiac drugs, with detrimental effects patient safety investments made by pharmaceutical industry. Moss Schwartz hypothesized might represent “forme fruste” congenital long syndrome...
1. Human and murine neuroblastoma cell lines were used to investigate, by the whole-cell patch-clamp technique, properties of a novel inward-rectifying K+ current (IIR) in adjustment resting potential (Vrest), which was range -40 -20 mV. 2. When elicited from holding 0 mV, IIR completely inactivated with time constants ranging 13 ms at -140 mV 4.5 s -50 The steady-state inactivation curve (h(V)) found be independent [Na+]o [K+]o (2-80 mM) could fitted Boltzmann steep slope factor 5-6, V1/2...
Cigarette smoking is an important environmental factor affecting inflammatory bowel disease. The role of has not been rigorously studied in microscopic colitis (MC). aim this study was to compare the association cigarette individuals with MC compared a control population without MC.We reviewed records patients clinical and histologic diagnosis collagenous (CC) or lymphocytic (LC). Clinical history, including alcohol status at time MC, were reviewed. In case-control study, age- gender-matched...
Renal targets of autoimmunity in human lupus nephritis (LN) are unknown. We sought to identify autoantibodies and glomerular target antigens renal biopsy samples from patients with LN determine whether the same can be detected circulation. Glomeruli were microdissected 20 characterized by proteomic techniques. Serum large cohorts systemic erythematosus (SLE) without other glomerulonephritides tested. Glomerular IgGs recognized 11 podocyte antigens, reactivity varying pathology. Notably, IgG2...
Mutations in the minK gene KCNE1 have been linked to LQT5 variant of human long QT syndrome. MinK assembles with KvLQT1 produce slow delayed rectifier K+current IKs and may assemble HERG modulate rapid IKr. We used electrophysiological immunocytochemical methods compare cellular phenotypes wild-type four mutants co-expressed Xenopus oocytes HEK293 cells. found that three mutants, V47F, W87R D76N, were expressed at cell surface, while one mutant, L51H, was not. Co-expression V47F produced...
Background —The congenital long-QT syndrome (LQTS) is a genetically heterogeneous disease characterized by prolonged ventricular repolarization and life-threatening arrhythmias. Mutations of the KVLQT1 gene, cardiac potassium channel, generate two allelic diseases: Romano-Ward syndrome, inherited as dominant trait, Jervell Lange-Nielsen an autosomal recessive trait. Methods Results —A consanguineous family with clinical phenotype LQTS was screened for mutations in gene. Complementary RNAs...
Abstract Background Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages malignant transformation. Based on phenomenon field cancerization, tissue in tumor can be used to identify and study initiating events carcinogenesis. Morphological changes nuclear organization have been implicated colorectal cancer (CRC), we hypothesize that characterization chromatin early CRC will provide insight into progression,...
Developing a minimally invasive and cost-effective prescreening strategy for colon cancer is critical because of the impossibility conducting colonoscopy on entire at-risk population. The concept field carcinogenesis, in which normal-appearing tissue away from tumor has molecular and, consequently, nano-architectural abnormalities, offers one attractive approach to identify high-risk patients. In this study, we investigated whether novel imaging technique partial wave spectroscopic (PWS)...
Potassium homeostasis plays an important role in the control of neuronal excitability, and diminished buffering extracellular K results Hyperexcitability abnormal synchronization. Astrocytes are cellular elements primarily involved this process. uptake into astrocytes occurs, at least part, through voltage-dependent channels, but exact mechanisms not fully understood. Although most glial recordings reveal expression inward rectifier currents (K IR ), it is clear how spatial consisting...
Although strenuous exercise has been reported to increase gastroesophageal reflux, there are few data exploring the mechanism behind this relationship. The aim of study was use vigorous as a provocation for strain-induced reflux and examine correlation between endoscopically assessed EGJ integrity exercise-induced reflux.Ten controls 10 GERD patients were studied 2-day period using wireless Bravo pH monitoring system. subjects randomly assigned perform 60 min on day 1 or 2 consuming same...
Obsessive-compulsive disorder (OCD) has been successfully treated with proserotonergic agents for some years. Clomipramine was the first drug used, but several clinical trials have conducted more recently to assess antiobsessional efficacy of selective serotonin reuptake inhibitors (SSRIs). The aim this study compare three SSRIs, fluvoxamine, paroxetine, and citalopram. Thirty obsessive-compulsive patients without co-morbid axis I diagnoses except tic as assessed by DSM-III-R criteria gave...
Background Sodium-glucose cotransporter proteins (SGLT) belong to the SLC5A family, characterized by cotransport of Na+ with solute. SGLT1 is responsible for intestinal glucose absorption. Until recently only role described SGLT was transport sugar Na+. However, human SGLT3 (hSGLT3) does not but causes depolarization plasma membrane when expressed in Xenopus oocytes. For this reason suggested be a sensor rather than transporter. Despite 70% amino acid identity between hSGLT3 and hSGLT1,...
Neuronal DEG/ENaC (degenerin and epithelial Na + channel) channels have been implicated in touch sensation. For example, MEC-4 is expressed neurons Caenorhabditis elegans mediates gentle-touch response. Similarly, homologous mammalian ASIC2 ASIC3 are sensory produce phenotypes when knocked out mice. Here, we show that novel subunits DELM-1 DELM-2 (degenerin-like channel mechanosensory linked-1 degenerin-like linked-2) glia associated with C. their knock-out causes defects behaviors related...