A5011840225- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Microbial infections and disease research
- Immune responses and vaccinations
- vaccines and immunoinformatics approaches
Roslin Institute
2022-2025
University of Edinburgh
2022-2025
Centre for Inflammation Research
2022-2023
The Queen's Medical Research Institute
2022-2023
Leiden University Medical Center
2023
<title>Abstract</title> Research on chemokines in cattle is hampered by the relative lack of reagents. Bovine IP-10 an important inflammatory chemokine and a promising diagnostic biomarker for economically disease (bovine tuberculosis) caused infection with <italic>Mycobacterium bovis</italic>. Currently no monoclonal antibodies are available bovine IP-10. The goal this study was to generate novel mAbs detection using recombinant hybridoma technology. Five were developed cross clone...
Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In UK, control bTB relies on detection via tuberculin skin tests ancillary interferon gamma (IFN-γ) release assays, followed by culling infected animals. Vaccination Bacille Calmette-Guérin (BCG) could be an important element control, number studies have demonstrated its protective efficacy, particularly when young calves...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis ( M. ) infection in cattle, is an economically devastating chronic disease for livestock worldwide. Efficient control measures rely on early and accurate diagnosis using the tuberculin skin test (TST) interferon-gamma release assays (IGRAs), followed culling of positive animals. Compromised performance TST IGRA, due to BCG vaccination or co-infections with non-tuberculous mycobacteria (NTM), urges improved diagnostics. Lateral flow...
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a globally prevalent infectious disease with significant animal welfare and economic impact. Difficulties in implementing test-and-slaughter measures low- middle-income countries (LMICs) the underperformance of current diagnostics establish clear need to develop improved diagnostics. Adaptive immunity biomarkers other than IFNγ could be useful as suggested various gene expression studies; however, comprehensive assessment at...