A5005466930- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Aortic aneurysm repair treatments
- Health and Well-being Studies
- Cancer, Hypoxia, and Metabolism
- Organ Transplantation Techniques and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Infective Endocarditis Diagnosis and Management
- Spinal Cord Injury Research
- Neurogenetic and Muscular Disorders Research
- Renal and Vascular Pathologies
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
Cedars-Sinai Smidt Heart Institute
2023-2024
Cedars-Sinai Medical Center
2023-2024
Kyoto Prefectural University of Medicine
2019-2023
Okinawa Prefectural Chubu Hospital
2018-2023
National Cerebral and Cardiovascular Center
2020-2022
Research Network (United States)
2021
Hospital Universitario La Paz
2021
Hartford Financial Services (United States)
2021
Amyloidosis Foundation
2021
National Heart Foundation of Australia
2021
Background The interaction between right ventricular (RV) function and pulmonary hypertension is crucial for prognosis of patients with severe functional tricuspid regurgitation. RV free wall longitudinal strain (RVFWLS) has been reported to detect systolic dysfunction earlier than other conventional parameters. Although artery pressure measured by Doppler echocardiography often underestimated in regurgitation, atrial (RAP) estimated may be viewed as a prognostic factor. Impact RAP RVFWLS on...
The outcomes of patients with hypertrophic cardiomyopathy left ventricular systolic dysfunction (HCM-LVSD) undergoing assist device (LVAD) implantation remain unclear. We retrospectively evaluated the clinical impact LVAD on outcomes, including haemodynamics and brain natriuretic peptide (BNP) levels, in HCM-LVSD, comparison those dilated (DCM).
Sarcopenia is characterized by progressive loss of skeletal muscle and has frequently been associated with poor clinical outcomes in patients advanced heart failure (HF). The urinary creatinine excretion rate (CER) index an easily measured marker mass, but its predictive capacity for mortality cerebrovascular events not investigated a continuous-flow implantable left ventricular assist device (CF-iLVAD).
With the aging population and advanced catheter-based therapy, isolated tricuspid regurgitation (TR) with atrial fibrillation (AF) has gained increased attention; however, data on prognostic effect of TR AF are limited because small number patients among those severe TR. Recently, right ventricular (RV) longitudinal strain by two-dimensional speckle-tracking echocardiography been reported as an excellent indicator RV dysfunction in However, implications associated remain unclear. Therefore,...
Abstract Objectives Right ventricular (RV)–pulmonary arterial (PA) coupling is important in various cardiac diseases. Recently, several echocardiographic surrogates for RV–PA have been proposed and reported to be useful predicting outcomes. However, it remains unclear which surrogate the most clinically relevant. This study aimed comprehensively compare prognostic value of different surrogates. Methods We retrospectively reviewed 242 patients with conditions who underwent comprehensive...
Appropriate indications and protocols for induction therapy using basiliximab have not been fully established in heart transplant (HTx) recipients. This study elucidated the influence of along with delayed tacrolimus (Tac) initiation on outcomes high-risk HTx
Abstract Aortic insufficiency (AI) is an important adverse event in patients with continuous-flow (CF) left ventricular assist device (LVAD) support. AI often progressive, resulting elevated 2-year morbidity and mortality. The effectiveness of echocardiographic ramp studies has been unclear. Here, we describe a patient CF-LVAD implant who underwent aortic valve replacement (AVR), following assessment using hemodynamic test simultaneous echocardiography right heart catheterization (RHC). was...
A recently indicated immunotherapy strategy, combined with mechanical circulatory support (MCS), seems to improve outcomes in patients fulminant giant cell myocarditis (GCM). However, characterizing a definitive clinical outcome of this strategy remains challenging, and the autoimmunity associated onset GCM controversial.A 26-year-old man poor control atopic dermatitis ulcerative colitis presented cardiogenic shock requiring MCS. He was diagnosed GCM; hence, (including steroids intravenous...
Implantable left ventricular assist devices (LVAD) have improved quality of life and survival in patients with advanced heart failure. However, LVAD-specific infections predicting which will develop remain challenging. This study investigated whether changes body mass index (BMI) during hospitalization following LVAD implantation are associated within 1 year implantation.
Background: Although metabolic alterations were observed in heart failure (HF), only recently have the mechanisms underlying these changes been identified. Tumor suppressor p53 responds to thorough several mechanisms. One of targets, TIGAR (TP53-induced glycolysis and apoptosis regulator) reduces suppresses autophagy, which augments ischemic damage, however its role on HF is unclear. Method Results: In order investigate TIGAR’s function HF, we compared myocardial functional outcomes between...
Abstract Background Ischemic disease is prevalent in elderly population due to impaired angiogenesis. Endothelial cell (EC) generates energy largely via glycolysis, which further activated when angiogenesis actively occurs. PFK-1 one of the most important regulatory enzymes for by PFKFB3. On other hand, TIGAR inhibits under control p53. Crucial roles PFKFB3 EC functions physiological and pathological conditions have been reported; however, a role angiogenic remains be elucidated....
Introduction: Current prognostic models to predict survival in heart transplant (HTx) recipients, which are ‘Index for Mortality Prediction After Cardiac Transplantation (IMPACT) model’ using the recipient-factor and ‘International Heart Survival Algorithm (IHTSA) both recipient- donor-factors, have been verified good adaptation on global registry data HTx recipients. In Japan, extremely serious donor shortages will necessitate a long waiting period, more marginal hearts. But several risk...
Acquired coarctation of the aorta (CoA) following total aortic arch replacement (TAR) is a rare complication inducing left ventricular (LV) dysfunction probably due to increased LV afterload and secondary hypertension caused by upper body decreased renal blood flow. We describe case 35-year-old male who developed atypical CoA with severe ejection fraction 10%, but without after TAR using conventional elephant trunk (ET) technique for acute dissection. Computed tomography revealed...
Abstract Background Myocardial infarction (MI) caused by acute type A aortic dissection (AAD) is a rare but serious complication. To avoid unnecessary and possibly harmful treatment, differentiation of AAD-MI from atherosclerotic MI (AMI) very important. However, there paucity data regarding between AMI. Purpose compare the differences clinical features AMI, develop an effective way differentiation. Methods Among 318 cases with AAD 1982 2020, 18 (5.7%) had AAD-MI, which 13 inferior wall...