A5011208782- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Intergenerational Family Dynamics and Caregiving
- Health, Environment, Cognitive Aging
- COVID-19 and healthcare impacts
- Genetic Syndromes and Imprinting
- Animal Virus Infections Studies
- Ethics in Clinical Research
- Respiratory viral infections research
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Bacillus and Francisella bacterial research
- Muscle and Compartmental Disorders
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
University of Edinburgh
2017-2024
Western General Hospital
2017-2023
International Severe Acute Respiratory and Emerging Infection Consortium
2023
St Mary's Hospital
2023
University of Sheffield
2021-2022
Centre for Inflammation Research
2022
The Queen's Medical Research Institute
2022
University of Glasgow
2022
MRC University of Glasgow Centre for Virus Research
2022
Medical Research Council
2022
Gene expression is influenced by both genetic variants and the environment.As individuals age, changes in gene may be associated with decline physical cognitive abilities.We measured transcriptomewide levels lymphoblastoid cell lines derived from members of Lothian Birth Cohort 1936 at mean ages 70 76 years.Changes were identified for 1,741 transcripts 434 individuals.Gene Ontology enrichment analysis indicated an biological processes involved immune system.Transcriptome-wide association was...
<ns4:p><ns4:bold>Background:</ns4:bold> DNA methylation reflects health-related environmental exposures and genetic risk, providing insights into aetiological mechanisms potentially predicting disease onset, progression treatment response. An increasingly recognised need for large-scale, longitudinally-profiled samples collected world-wide has made the development of efficient straightforward sample collection storage procedures a pressing issue. alternative to low-temperature EDTA tubes...
Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline neurodegenerative disease. However, it is unclear how these blood-based relate within brain each associates with central cellular profiles. In this study, we profiled both five post mortem regions (BA17, BA20/21, BA24, BA46 hippocampus) 14 individuals from Lothian Birth Cohort 1936. Microglial burdens were additionally quantified same regions....
Abstract Modifiable lifestyle factors influence the risk of developing many neurological diseases. These have been extensively linked with blood-based genome-wide DNA methylation, but it is unclear if signatures from blood translate to target tissue interest—the brain. To investigate this, we apply blood-derived epigenetic predictors four traits methylation five post-mortem brain regions and last sample prior death in 14 individuals Lothian Birth Cohort 1936. Using these matched samples,...
Abstract Background Newborn heel prick blood spots are routinely used to screen for inborn errors of metabolism and life-limiting inherited disorders. The potential value secondary data from newborn spot archives merits ethical consideration assessment feasibility public benefit. Early life exposures behaviours set health trajectories in childhood later life. is potentially well placed create an unbiased cost-effective population-level retrospective birth cohort study. Scotland has retained...
Abstract Inflammation and ageing-related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline neurodegenerative disease. However, it is unclear how these blood-based relate within brain, each associates with central cellular profiles. In this study, we profiled both five post-mortem brain regions (BA17, BA20/21, BA24, BA46 hippocampus) 14 individuals from Lothian Birth Cohort 1936. Microglial burdens were additionally quantified same...
Abstract Background DNA methylation reflect health-related environmental exposures and genetic risk, providing insights into aetiological mechanisms potentially predicting disease onset, progression treatment response. An increasingly recognised need for large-scale, longitudinally-profiled samples collected world-wide has made the development of efficient straightforward sample collection storage procedures a pressing issue. alternative to low-temperature EDTA tubes venous blood samples,...
Abstract Modifiable lifestyle factors influence the risk of developing many neurological diseases. These have been extensively linked with blood-based genome-wide DNA methylation (DNAm), but it is unclear if signatures from blood translate to target tissue interest - brain. To investigate this, we apply blood-derived epigenetic predictors four traits DNAm five post-mortem brain regions and last sample prior death in 14 individuals Lothian Birth Cohort 1936 (LBC1936). Using these matched...
Abstract New-born heel prick blood spots are routinely used to screen for inborn errors of metabolism and life-limiting inherited disorders1. The Danish Newborn Screening Biobank (DNSB) has shown that nucleic acid, metabolic protein assays feasible on archived new-born dried spots2. Denmark is currently the only country in world where nation-level linkage such secondary data health records approved2. In new era science predictive medicine, potential value from spot archives merits wider...