A5057906019- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- Synthesis of Indole Derivatives
- Catalytic Alkyne Reactions
- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Synthesis and Biological Evaluation
- Metal-Organic Frameworks: Synthesis and Applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthetic Organic Chemistry Methods
- Covalent Organic Framework Applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Chemical Reaction Mechanisms
Wuhan Institute of Technology
2018-2025
Wuhan University
2011-2023
Molecular Sciences Institute
2023
Anhui Polytechnic University
2014
Nankai University
1997-2012
Abstract The first catalytic asymmetric 1,3‐dipolar cycloaddition of azomethine ylides with various sterically hindered α,α,β‐trisubstituted 2‐alkylidene‐cycloketones has been developed successfully silver acetate/TF‐BiphamPhos complex for the construction spiro heterocyclic compounds containing pyrrolidine motifs and a quaternary stereogenic carbon center. highly efficient system exhibited high reactivity, excellent diastereoselectivity, good enantioselectivity broad substrate scope under...
A direct and facile synthesis of highly functional 5-aza-spiro[2,4]heptanes, a valuable structural motif for drug discovery, is developed viacatalytic asymmetric 1,3-dipolar cycloaddition cyclopropylidene acetate azomethine ylides the first time.
A facile synthesis of highly functional spiro-[4-chromanone-3,3′-pyrrolidine] bearing one unique spiro quarternary and three tertiary stereogenic centers is developed in excellent stereoselectivity for the first time.
A highly enantioselective desymmetrization of prochiral cyclopentenediones via Ag(I)-catalyzed asymmetric 1,3-dipolar cycloaddition azomethine ylide has been developed successfully. The methodology performs well over a broad scope substrates, which provides facile access to series functionalized bicyclic pyrrolidine/cyclopentane derivatives in good high yields with excellent stereoselectivities.
Facile access to enantioenriched isoindolines bearing a quaternary stereogenic center and tertiary was successfully developed via highly efficient Cu(I)/(S,Rp)-PPFOMe-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylide with quinone derivatives followed by silica-gel-promoted aromatization in one-pot reaction protocol. The present catalytic system exhibited high diastereoselectivity, excellent enantioselectivity, broad substrate scope under mild conditions.
Pyrrole into one: The catalytic asymmetric 1,3-dipolar cycloaddition of cyclic aldimino esters has been accomplished for the first time, enabling facile access to spiro(butyrolactonepyrrolidines) containing one spiro quaternary center and three tertiary stereogenic centers (see scheme). system performs well with a broad range substrates, furnishing synthetically useful adducts in high yields, excellent diastereo- enantioselectivities under mild conditions.
A highly exo-selective 1,3-dipolar [3 + 6] cycloaddition of azomethine ylides with 2-acylcycloheptatrienes was realized a Cu(I)/(S,Rp)-PPF-NHMe complex as the catalyst, leading to diverse range bridged piperidines multiple functionalities in good yield excellent stereoselectivity control. Theoretical calculations indicated stepwise mechanism for this annulation, which accounts remarkable feature annulation: all larger substituent groups occupy axial positions six-membered chairlike...
A [5+1] annulation between in situ generated aza‐o‐quinone methides and primary amines has been developed. This methodology offers efficient access to diverse 3,4‐dihydroquinazolin‐2(1H)‐one derivatives with yields ranging from 45 99%. The significance of this is highlighted by its application the synthesis a potential CDK5 inhibitor, bioactive compound.
Transition metal palladium-catalyzed asymmetric reaction is an important and efficient method to synthesize chiral compounds.It has made considerable progress achieved great success in the past decades.However, some reactions could not achieve high reactivity excellent stereoselectivity just promoted by transition palladium catalysis.Therefore, it of significance combine catalysis organocatalysis, which be conducive dissolve these challenging problems received attention.In recent years, a...
Comprehensive Summary Transition metal‐catalyzed asymmetric hydrogenation is an efficient and direct synthetic method to access chiral compounds, which features simplicity, easy working‐up process, high atomic economy. It typically relies on precious transition metal catalytic systems, including ruthenium, rhodium, iridium palladium, always face the difficulties of limited resources, cost, environmental contamination. Therefore, great efforts were made apply earth‐abundant, low (non‐)toxic,...
An unprecedented Ag(i)-catalyzed tandem [6+3] cycloaddition/isomerization of isocyanoacetates with fulvenes has been developed, affording the fused dihydropyridine derivatives in good yields exclusive regioselectivities.
Chiral benzoxazinones and 4H-3,1-benzoxazines as important motifs are widely found in abundant pharmaceuticals biological molecules. We herein successfully developed the first kinetic resolution (KR) process of racemic through Ir-catalyzed asymmetric intramolecular allylation, furnishing a wide range chiral with excellent results via outstanding KR performances (with s factor up to 170). This protocol exhibited broad substrate scope generality good functional group tolerance,...
Catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with dimethyl itaconate and 2-methyleneglutarate was realized Cu(<sc>i</sc>)/TF–BiphamPhos complex as the catalyst for efficient construction pyrrolidine derivatives bearing one unique all carbon-quaternary two tertiary stereogenic centers.
A spiroannulation reaction of β-ketothioamides with aromatic β-bromoenals and α-bromoenals via selective