A5083075753- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- COVID-19 Impact on Reproduction
- Polyomavirus and related diseases
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
Henry M. Jackson Foundation
2015-2025
Walter Reed Army Institute of Research
2022-2023
National Institutes of Health
2023
National Cancer Institute
2023
University College London
2015
University of KwaZulu-Natal
2015
Anova Health Institute
2015
University of Cape Town
2015
Stellenbosch University
2015
Perinatal HIV Research Unit
2015
Abstract Background Reassortant influenza strains containing genes from human, avian, and/or swine origin, have led to major outbreaks, such as the 2009 flu pandemic. The ongoing global spread of highly pathogenic avian (HPAI) A/H5N1 virus among poultry highlights risk zoonotic transmission leading pandemics. A universal vaccine that generates broadly neutralizing antibodies against viruses is crucial for preventing future Previous studies with our unconjugated composite peptide (two-peptide...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines demonstrate reduced protection against acquisition of BA.5 subvariant but are still effective severe disease. However, immune correlates remain unknown. We report the immunogenicity and protective efficacy vaccine regimens consisting vector-based Ad26.COV2.S adjuvanted spike ferritin nanoparticle (SpFN) a high-dose, mismatched Omicron challenge in macaques. The SpFNx3 Ad26 + SpFNx2 elicit higher antibody responses than...
The WHO recommends protease inhibitor (PI)-based antiretroviral therapy (ART) for vertically infected children after failed nevirapine (NVP) prophylaxis. Emergence of PI resistance on the backdrop preexisting non-nucleoside reverse transcriptase (NNRTI) could compromise long-term treatment options in such children. We characterized multiclass drug using single genome sequencing (SGS) with viremia while receiving PI-based ART. applied SGS HIV-1 (PR) and to longitudinal samples from a cohort...
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and waning immunity call for next-generation vaccine strategies. Here, we assessed the immunogenicity protective efficacy of two SARS-CoV-2 vaccines targeting WA1/2020 spike protein, Ad26.COV2.S (Ad26) Spike ferritin Nanoparticle (SpFN), in nonhuman primates, delivered as either a homologous (SpFN/SpFN Ad26/Ad26) or heterologous (Ad26/SpFN) prime-boost regimen. The Ad26/SpFN regimen elicited highest CD4 T cell...
An unconjugated composite peptide vaccine targeting multiple conserved influenza epitopes from hemagglutinin, neuraminidase, and matrix protein formulated with a safe highly potent adjuvant, Army Liposome formulation (ALFQ), generated broad durable immune responses in outbred mice. The antibodies recognized specific peptides several human, avian, swine viruses. Comparable antibody to viruses were observed intramuscular intradermal routes of administration. induced cross-reactive that virus...
Abstract Background Traditional influenza vaccine production often leads to mismatch due antigenic drift, thereby reducing protection. Alternate strategies that are peptide-based, nanoparticle-based or nucleic acid-based being developed. Composite multi-epitope peptides provide a cost-effective and easily scalable strategy towards universal vaccine. In this study, we demonstrate unconjugated, formulated with the highly potent adjuvant Army Liposome Formulation QS-21 (ALFQ) generate broadly...