A5061494232- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Systemic Lupus Erythematosus Research
- Viral Infections and Immunology Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Food Allergy and Anaphylaxis Research
- Cytokine Signaling Pathways and Interactions
- Hepatitis C virus research
- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Proteins in Food Systems
- Protein Hydrolysis and Bioactive Peptides
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Contact Dermatitis and Allergies
University of Pisa
2015-2023
Center for Rheumatology
2021-2023
University of Perugia
2021
Istituto di Fisiologia Clinica
2021
The interest in agri-food residues and their valorization has grown considerably, many of them are today considered to be valuable, under-exploited sources different compounds notably proteins. Despite the beneficial properties legumes by-products, there also some emerging risks consider, including potential allergenicity. In this work immunoreactivity chickpea, pea, white bean by-products was assessed, whether production enzymatic hydrolysates can an effective strategy reduce allergenic...
Abstract: Chronic urticaria (CU) is a mast cell-driven disease characterized by the development of wheals, angioedema, or both for more than 6 weeks. The two major sub-types are chronic spontaneous (CSU) and inducible urticaria. In last decade different pathophysiological mechanisms, potentially responsible disease, have been described. It likely that activation cells basophils in CSU can be results immune system dysregulation, inflammatory cascade, extrinsic coagulation pathway. Some...
The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up systemic lupus erythematosus (SLE) patients. presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (Crithidia Luciliae immunofluorescence test (CLIFT)). To overcome limits CLIFT solid chromatin assays, we explored diagnostic potential an assay based on plasmid DNA containing highly bent fragment 211 bp from Crithidia minicircles, complexed with histone...
Urticarial vasculitis (UV) is a small-vessel leukocytoclastic characterized by different clinical manifestations ranging from long-lasting urticarial lesions to severe and potentially life-threatening multi-organ involvement. Omalizumab (OMA), anti-IgE recombinant humanized IgG1 monoclonal antibody, has been successfully used treat few cases of and/or refractory UV. In this study we report our experience on 6 patients with normocomplementemic UV treated therapy suggesting that biological may...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the mucosa and paranasal sinuses that often coexists asthma. The role atopy in development severity CRSwNP still controversial issue.The aim our study was to propose systematic allergy workup identify atopic patients context characterize their allergen sensitization profile (sources/molecules).Patients diagnosis (n = 97) were studied otorhinolaryngologist settings. Demographic...
Hypersensitivity reactions (HSR)s to platinum agents are increasing in frequency, due their extensive use and repeated exposures patients with increased life expectancy. The aims of our study analyze the frequency both type I IV HSRs gynecological cancer treated (CBDCA) carboplatin and/or (CDDP) cisplatin, evaluate role skin tests diagnosis prevention HSRs. From 2011 2018, we evaluated 124 consecutive female previously CBDCA CDDP for cancer. All patients, including those without HSR previous...
<h3>Background</h3> The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up SLE patients. presently available assays are characterized by a non-optimal specificity (solid phase assays) or sensitivity (CLIF test). <h3>Objectives</h3> To overcome limits CLIFT solid chromatin assays, we explored diagnostic potential an assay based on plasmid DNA containing highly bent fragment 211 bp from <i>Crithidia Luciliae</i> microcircles, complexed with histone peptides....