A5074892994- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound in Clinical Applications
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiac Arrest and Resuscitation
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrospinal fluid and hydrocephalus
- Machine Learning in Healthcare
- Prenatal Screening and Diagnostics
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Hernia repair and management
- Musculoskeletal pain and rehabilitation
- Testicular diseases and treatments
- Spinal Fractures and Fixation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiology practices and education
- Neonatal Respiratory Health Research
KK Women's and Children's Hospital
2011-2024
Singapore General Hospital
2002-2021
Duke-NUS Medical School
2019-2020
National Neuroscience Institute
2008-2019
Institute of Precision Mechanics
2019
Dr. Shterev Hospital
2019
SingHealth
2019
National University of Singapore
2000-2016
Boston Children's Hospital
2012
University of California, San Francisco
2008
Anomalies associated with callosal agenesis (ACC) found postnatally have been well documented. However, to our knowledge, no detailed MR imaging analysis of anomalies has reported in a large cohort fetuses ACC. This study will assess those and compare them postnatal cohorts ACC, identify fetal brain abnormalities that may give insight into etiology outcome.All cases ACC diagnosed on during an 11-year period were retrospectively reviewed, including imaging, autopsy findings....
The aim of this study was to review the clinical, computed tomography (CT) and magnetic resonance imaging (MRI) diagnosis frequency positive neuroimaging findings in patients with cerebral venous thrombosis (CVT) involving superior sagittal sinus.A clinical radiological database final CVT compiled from inpatient hospital information service a tertiary neurological over 5 years. CT MRI studies 22 were retrospectively examined for direct signs sinus complications CVT. before after...
MYCN oncogene amplification is closely linked to high-grade neuroblastoma with poor prognosis. Accurate quantification essential for risk assessment, which guides clinical decision making and disease management. This study proposes an end-to-end deep-learning framework automatic tumor segmentation of pediatric neuroblastomas radiomics features-based classification gene amplification.Data from pretreatment contrast-enhanced computed tomography scans status 47 cases treated at a tertiary...
Abstract Background Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and patients have higher incidence of metastatic disease, especially involving neuroaxis. At present, mechanisms underlying MB metastasis remain elusive. Separately, inflammation has been implicated as key player in tumour development metastasis. Cytokines their inflammation-related partners demonstrated to act on autocrine and, or paracrine pathways within...
Previous studies revealed that the ordering of Magnetic resonance imaging (MRI) brain scans following American College Radiology (ACR) guidelines showed a higher percentage abnormalities compared to do not. As process manually labelling patient orders obtained from local tertiary hospital in accordance ACR is intensive and time consuming, this study aims develop predictive machine learning models; Logistic Regression (LR), Support Vector Machine (SVM), Random Forest (RF) XGBoost (XGB),...
We explored the potential for over-compression from current paediatric chest compression depth guidelines using computed tomography(CT) images of a large, heterogenous, Asian population.A retrospective review consecutive children, less than 18-years old, with CT performed between 2005 to 2017 was done. Demographic data were extracted electronic medical records. Measurements internal and external anterior-posterior diameters (APD) taken at lower half sternum. Simulated compressions evaluate...
The American College of Radiology (ACR) has guidelines on appropriate ordering Magnetic Resonance Imaging (MRI) brain scans. MRI requests are currently manually reviewed by radiologists to ensure compliance these guidelines. In this paper, we implemented a stacked recurrent neural network (RNN) utilizing bidirectional long short-term memory (Bi-LSTM) sequence with BioWordVec, biomedical word embedding vector that uses representations from lexicon developed medical publications, develop an...
Background: The Moyamoya disease is a cerebrovascular that causes occlusion of the distal end internal carotid artery, leading to formation multiple tiny collateral arteries. To date, pathogenesis unknown. Improved understanding changes vascular geometry and fluid mechanics siphon during may improve pathogenesis, prognosis techniques management. Methods: A retrospective analysis Magnetic Resonance Angiography (MRA) images was performed for pediatric patients (MMD) (n = 23) control (Ctrl)...
We report two cases of hypothalamic hamartoma associated with suprasellar cysts that were diagnosed by fetal magnetic resonance imaging (MRI) in our institution. In the first case, a 34-year-old woman, gravida 3 para 1, presented trimester pregnancy. She had undergone termination previous pregnancy because midline abnormalities (cleft lip and palate absent cavum septi pellucidi, normal karyotype). Ultrasound examination at 20 weeks' gestation showed 6.4 × 5.2-mm cyst anterior to cerebellum....
Chronic postsurgical pain (CPSP) occurs in up to 50% of individuals after surgeries and 32% hysterectomy, leading major adverse effects on quality life socioeconomic burden. Little is known about whether how large-scale neural networks being affected CPSP, particularly with regard the functional connectivity (FC) insula which be hub intrinsic network playing a critical role processing. Here, we sought examine dynamics insular FC context noxious stimuli CPSP patients. To this aim, resting...
Introduction: Although uncommon, fractures of the os odontoideum are known to occur in children under 7 years old, following acute trauma. Clinical Picture: We report a case chronic subluxation resulting cervical myelopathy child with Beare-Stevenson cutis gyrata syndrome after surgery head and neck. Treatment Outcome: The patient was initially put Halo vest, which occipital fusion performed. Conclusion: Subluxations at odontoid synchondrosis rare but should be anticipated young risk factors...
Fetal imaging has improved with the development of faster magnetic resonance (MRI) sequences, obviating requirement for sedation. It is useful in characterising abnormality central nervous system fetuses abnormal or equivocal antenatal ultrasound findings. We reviewed all cases fetal brain and spine MRI performed our institution.All from May 2006 to December 2008 were retrospectively reviewed, including MRI, postnatal autopsy findings.Thirty-one imaged evaluation which 3 specifically spinal...
Background: In Primary Angiitis of the Central Nervous System (PACNS), disease is typically limited to brain and spinal cord although other organs may be affected. Uveitis occasionally seen in systemic vasculitides but not a recognized manifestation PACNS. We describe two patients who developed PACNS following onset uveitis. Case Descriptions: 1-A 47-year-old male suffered multiple TIAs left pontine stroke shortly after episodes diffuse A cerbral angiogram demonstrated caliber changes within...
This study explored how body habitus in the paediatric population might potentially affect use of one-third external anterior-posterior (APD) diameter when compared to age-appropriate absolute chest compression depth targets. It also could relationship between and internal APD (compressible space) if indices were independent predictors at lower half sternum.This was a secondary analysis retrospective computed tomography (CT) scans infants children (>24-hours-of-life less-than-18-years-old)...