A5100738811- Cancer Mechanisms and Therapy
- Chromatin Remodeling and Cancer
- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Systemic Lupus Erythematosus Research
- Advanced X-ray and CT Imaging
- Sphingolipid Metabolism and Signaling
- interferon and immune responses
- Sulfur Compounds in Biology
- Mechanisms of cancer metastasis
- Adrenal and Paraganglionic Tumors
- Radiation Dose and Imaging
- Redox biology and oxidative stress
- Ovarian cancer diagnosis and treatment
- Cholesterol and Lipid Metabolism
- Soft tissue tumor case studies
- Organ and Tissue Transplantation Research
- Cerebrovascular and Carotid Artery Diseases
- RNA regulation and disease
- Xenotransplantation and immune response
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Tracheal and airway disorders
Zhejiang University
2022-2024
University of South China
2023
University of Florida
2009-2022
Zhejiang A & F University
2022
Simula Metropolitan Center for Digital Engineering
2022
Nanjing Medical University
2022
South China Agricultural University
2022
Chinese University of Hong Kong
2022
China Agricultural University
2022
Hebei Medical University
2022
Diffuse alveolar hemorrhage (DAH) in lupus patients confers >50% mortality, and the cause is unknown. We undertook this study to examine pathogenesis of DAH C57BL/6 mice with pristane-induced lupus, a model human lupus-associated DAH.Clinical/pathologic immunologic manifestations were compared those humans. Tissue distribution pristane was examined by mass spectrometry. Cell types responsible for disease determined vivo depletion using clodronate liposomes antineutrophil monoclonal...
BRG1 (SMARCA4) is a documented tumor suppressor and key subunit of the SWI/SNF chromatin remodeling complex that silenced in many cancer types. Studies have shown mutated cancer-derived cell lines, which led to assertion also primary human tumors. However, sequencing BRG1-deficient tumors has revealed paucity mutations; hence, cause silencing remains an enigma. We conducted immunohistochemistry (IHC) on number microarrays characterize frequency loss different analyzed by genomic DNA mRNA....
With the increasing global aging population, health and welfare of elderly individuals, especially individuals with prevalent mild cognitive impairment (MCI) living in nursing homes, have become critical concerns. These concerns highlight urgency developing effective interventions to address psychological needs ensuring their well-being alleviating burden on caregivers.
Abstract Context.—Desmoid tumors arising in the lung and pleura are extremely rare can resemble other, more common neoplasms native to these sites. Alterations of adenomatous polyposis coli/β-catenin pathway have been detected sporadic desmoid associated with nuclear accumulation β-catenin overexpression cyclin D1. Objective.—To analyze expression D1 solitary fibrous (SFTs), compare utilities substances for distinguishing between entities those commonly used stains. Design.—Formalin-fixed,...
Inactivation ofBrg1 and Brm accelerated lung tumor development, shortened latency, caused a loss of differentiation.Tumors with Brg1 and/or recapitulated the evolution human cancer as observed by development local invasion well distal metastasis, thereby making this model useful in studies.Brg1 contributed to metastasis part driving E-cadherin Vimentin up-regulation.By changing more than 6% murine genome down-regulation suppressors, DNA repair, differentiation cell adhesion genes,...
Once the knockout of Brm gene was found to be nontumorigenic in mice, study BRM's involvement cancer seemed less important compared with that its homolog, Brg1. This has likely contributed disparity been observed publication ratio between BRG1 and BRM. We show a previously published mouse is an incomplete whereby truncated isoform detected normal tissue tumors. this functionality comparable wild type Brm. By immunohistochemistry (IHC), undetectable lung minimal very low Brmnull However, it...
The SWI/SNF complex is an important regulator of gene expression that functions by interacting with a diverse array cellular proteins.The catalytic subunits SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in range different cancer types.This loss abrogates function as well the proteins required for function, such RB1 TP53.Yet while both known to be dependent on we found BRG1, but not functionally linked RB1, can directly indirectly inactivate pathway.This newly discovered...
Ischemia-reperfusion injury (IRI) after lung transplantation triggers a cascade of inflammatory changes that can contribute to acute allograft injury. This influences both the short- and long-term survival allograft. Alpha-1 antitrypsin (AAT) is protease inhibitor with known anti-inflammatory immune-regulatory properties mitigate tissue damage. study explores protective effects AAT in setting IRI utilizing rat transplant model.Orthotopic left single was performed from Lewis Sprague-Dawley...
Primary graft dysfunction and rejection are common complications in lung transplant recipients. Increased expression of thioredoxin-1 (Trx), a 12-kDa redox-regulatory protein, has been reported multiple pathophysiological conditions involving oxidative inflammatory mediated injury including canine rat models transplantation. Our objective was to determine whether increased Trx is associated with progression pathophysiology human Bronchoalveolar lavage (BAL) fluid transbronchial biopsy...
Human COPA mutations affecting retrograde Golgi-to-endoplasmic reticulum (ER) protein transport cause diffuse alveolar hemorrhage (DAH) and ER stress (“COPA syndrome”). Patients with SLE also can develop DAH. C57BL/6 (B6) mice pristane-induced lupus monocyte-dependent DAH indistinguishable from human DAH, whereas BALB/c are resistant. We examined Copa in lupus. expression, stress, vascular injury, apoptosis were assessed was quantified blood patients SLE. mRNA expression impaired B6 but not...
Hemangioblastoma primarily occurs in the CNS, most commonly posterior fossa. Extracranial locations are less common, and metastatic tumor involving lung is exceedingly rare with only three cases previously reported. Two were autopsy studies patients who died of complications CNS hemangioblastomas 1943 1981, third was mentioned a case report addendum providing follow-up information on hepatic hemangioblastoma 1991. We 48-year-old man presented multiple nodules treated by surgical excision....
Primary adrenal leiomyosarcoma (PAL) is an extremely rare mesenchymal tumor with only a few isolated case reports in the medical literature. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or endoscopic core biopsy (EUS-CB) safe, effective modality for sampling lesions gastrointestinal tract and adjacent organs, including glands. We describe of 50-year-old male presenting abdominal pain unintentional weight loss over course one year. CT imaging revealed 8.1 cm heterogeneous...
To evaluate dual-energy CT (DECT) findings of pulmonary ischaemic-reperfusion injury (PIRI) and its pathophysiological correlation in the canine model.A PIRI model was established 11 canines, utilizing closed pectoral balloon occlusion. Two control canines were also included. For model, left artery occluded with a balloon, which deflated removed after 2 h. DECT performed before, during occlusion at 2, 3 4 h thereafter utilized to construct perfusion maps. Immediately scan fourth hour post...
The role of large airway ischaemia, with resultant narrowing, in the development post-lung transplant bronchiolitis obliterans has not been defined. A determination clinical syndrome (BOS), which is defined as a decline FEV(1) from stable post-transplant baseline, difficult setting complications. aim this study was to assess evidence for histological lung allografts removed during retransplantation severe recurrent narrowing.Case records and findings allograft lungs at were retrospectively...
Tolerance to allograft antigen is the major challenge and final goal of transplant medicine. Our previous study demonstrated that thioredoxin-1 (Trx) priming donor lung significantly protected allogeneic graft. To determine whether Trx inhibits rejection, extends survival induces immune tolerance, orthotopic left transplantation was performed from Lewis Sprague-Dawley rats without immunosuppression. Donor lungs were primed with at 4°C for 4 hr prior transplantation. After up 37 days...