A5028832682- Biochemical Analysis and Sensing Techniques
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Plant-based Medicinal Research
- Microfluidic and Bio-sensing Technologies
- Angiogenesis and VEGF in Cancer
- HER2/EGFR in Cancer Research
- Complement system in diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and biological activity
- Phytochemical Studies and Bioactivities
- Quinazolinone synthesis and applications
- Sphingolipid Metabolism and Signaling
- Synthesis and Properties of Aromatic Compounds
- Fullerene Chemistry and Applications
- Protease and Inhibitor Mechanisms
- RNA and protein synthesis mechanisms
- Synthesis of Organic Compounds
A.E. Arbuzov Institute of Organic and Physical Chemistry
2011-2018
University of Florida
2013-2017
Russian Academy of Sciences
2012-2013
Diffuse alveolar hemorrhage (DAH) in lupus patients confers >50% mortality, and the cause is unknown. We undertook this study to examine pathogenesis of DAH C57BL/6 mice with pristane-induced lupus, a model human lupus-associated DAH.Clinical/pathologic immunologic manifestations were compared those humans. Tissue distribution pristane was examined by mass spectrometry. Cell types responsible for disease determined vivo depletion using clodronate liposomes antineutrophil monoclonal...
One of the keys for successfully developing drugs against broad spectrum cancer cell types is structural diversity. In current study, we focused on a family isosteviol derivatives as potential novel antitumor agents. Isosteviol tetracyclic diterpenoid obtained by acid hydrolysis steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. this work, have designed and synthesized panel triazole conjugates using “click” chemistry methodology. Evaluation these compounds series...
In order to identify biomarkers involved in breast cancer, gene expression profiling was conducted using human cancer tissues.Total RNAs were extracted from 150 clinical patient tissues covering three subtypes (Luminal A, Luminal B, and Triple negative) as well normal tissues. The profiles of a total 50,739 genes established training set 32 samples the Agilent Sure Print G3 Human Gene Expression Microarray technology. Data analyzed Spring GX 12.6 software. several validated real-time...
Two diterpenoid surfactants with ammonium head groups and bromide (S1) or tosylate (S2) counterions have been synthesized. Exploration of these biomimetic species made it possible to demonstrate that even minor structural changes beyond their chemical nature may dramatically affect solution behavior. While aggregation thresholds differ inconsiderably, morphological behavior affinity lipid bilayer are strongly dependent on the counterion nature. Compound S2 demonstrates properties typical...
Derivatives of isosteviol and steviol possessing choline moieties have been synthesized assayed for AchE BchE inhibitory activity.
Background: For the last two decades, diterpenoid isosteviol and its derivatives have gained significant attention for novel chemical transformation in drug discovery field. Results: An efficient way towards synthesis of structurally diverse was described here employing unsaturated functionalities as attractive templates further such epoxidation. These compounds exhibited promising cytotoxic activities on different types cancer cell lines, leading to derived from natural products treatment...
Lung cancer continues to be one the most prevalent and life threatening cancers worldwide. In order study gene regulation pattern in lung for new therapeutics discovery, expression profiling using human tissues was conducted. The profiles were established Affymetrix Human Exon 1.0 ST Array with RNA extracts from six clinical patients (five samples normal control). raw data analyzed Expression Console Transcriptome Analysis 2.0. of several genes further validated real-time reverse...
Protected arginine thioacid enables convenient N-acylation with no detectable racemization. We report efficient syntheses of potentially biologically active conjugates and novel arginine-containing di-, tri- tetrapeptides in good yields without loss chiral integrity.
Protected amino/peptide thioacids have been synthesized in pure form excellent yields and with retention of chirality by using protected aminoacyl- peptidoylbenzotriazoles as active intermediates.
Aminoacyl sulfamides represent a family of high-affinity inhibitors the specific aminoacyl tRNA synthetase activity. In this paper we describe synthesis novel sulfamide adenosine derivative 4 bearing pyroglutamyl fragment (pGlu-SA).