A5087227350- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Biochemical Analysis and Sensing Techniques
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Carbohydrate Chemistry and Synthesis
- Advanced Chemical Sensor Technologies
- Molecular spectroscopy and chirality
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Organophosphorus compounds synthesis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and biological activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Analysis
- Molecular Sensors and Ion Detection
- Synthesis and Reactions of Organic Compounds
- Plant biochemistry and biosynthesis
- Synthesis of Organic Compounds
- Molecular Spectroscopy and Structure
- Free Radicals and Antioxidants
- HIV/AIDS drug development and treatment
A.E. Arbuzov Institute of Organic and Physical Chemistry
2015-2024
Russian Academy of Sciences
2008-2021
Kazan Scientific Center
2007-2021
Kazan State Technological University
2003
Kazan Federal University
1978-2003
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
1976
A series of novel triphenylphosphonium (TPP) cations the diterpenoid isosteviol (1, 16-oxo-ent-beyeran-19-oic acid) have been synthesized and evaluated in an vivo phenotypic sea urchin embryo assay for antimitotic activity. The TPP moiety was applied as a carrier to provide selective accumulation connected compound into mitochondria. When fertilized eggs, targeted conjugates induced mitotic arrest with formation aberrant multipolar spindles, whereas both methyltriphenylphosphonium cation...
Mitochondria play a crucial role in the cell fate; particular, reducing accumulation of calcium mitochondrial matrix offers cardioprotection. This affect is achieved by mild depolarization membrane potential, which prevents assembly and opening permeability transition pore. For this reason, mitochondria are an attractive target for pharmacological interventions that prevent ischaemia/reperfusion injury. Isosteviol diterpenoid created from acid hydrolysis Stevia rebaudiana Bertoni (fam....
A series of glycosides and glycoconjugates diterpenoid isosteviol with various monosaccharide residues were synthesized. Most them showed moderate to significant cytotoxicity against human cancer cell lines M-HeLa MCF-7.
A series of 5'-phosphorylated (dialkyl phosphates, diaryl phosphoramidates, H-phosphonates, phosphates) 1,2,3-triazolyl nucleoside analogues in which the 1,2,3-triazole-4-yl-β-D-ribofuranose fragment is attached via a methylene group or butylene chain to N-1 atom heterocycle moiety (uracil quinazoline-2,4-dione) was synthesized. All compounds were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1). Antiviral assays revealed three compounds, 13b, 14b, and 17a, showed...
Two diterpenoid surfactants with ammonium head groups and bromide (S1) or tosylate (S2) counterions have been synthesized. Exploration of these biomimetic species made it possible to demonstrate that even minor structural changes beyond their chemical nature may dramatically affect solution behavior. While aggregation thresholds differ inconsiderably, morphological behavior affinity lipid bilayer are strongly dependent on the counterion nature. Compound S2 demonstrates properties typical...
Several glycoconjugates of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) with a 1,2,3-triazolyl moiety were synthesized, and their cytotoxicity was evaluated against some human cancer normal cell lines. Most synthesized compounds demonstrated weak inhibitory activities M-HeLa MCF-7 Three lead compounds, 54, 56 57, exhibited high selective cytotoxic activity cells (IC50 = 1.7–1.9 μM) that corresponded to anticancer drug doxorubicin 3.0 μM). Moreover, not respect Chang liver line...
Derivatives of isosteviol and steviol possessing choline moieties have been synthesized assayed for AchE BchE inhibitory activity.
A series of conjugates diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) and N-acetyl-D-glucosamine was synthesised their cytotoxicity against several human cancer cell lines (M-Hela, MCF-7, Hep G2, Panc-1, PC-3), as well normal (WI-38, Chang liver) assayed. Most the were found to be cytotoxic mentioned in range IC50 values 13–89 µM. Two lead compounds 14a 14b showed selective M-Hela (IC50 13 14 µM) that two times high anti-cancer drug Tamoxifen control 28 µM). It activity cells is due...