A5103281053- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Business Strategy and Innovation
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- vaccines and immunoinformatics approaches
- Erythrocyte Function and Pathophysiology
- Innovation and Knowledge Management
- SARS-CoV-2 and COVID-19 Research
- Muscle Physiology and Disorders
- Bacteriophages and microbial interactions
- Genetics and Neurodevelopmental Disorders
- Lipid Membrane Structure and Behavior
- Neurogenetic and Muscular Disorders Research
- Pluripotent Stem Cells Research
- Diversity and Career in Medicine
- Collaboration in agile enterprises
- Aging, Elder Care, and Social Issues
- Orthopaedic implants and arthroplasty
- Viral gastroenteritis research and epidemiology
- Ion channel regulation and function
- Wnt/β-catenin signaling in development and cancer
- Knowledge Management and Sharing
Beijing Normal University
2023-2024
Capital Medical University
2024
National Clinical Research Center for Digestive Diseases
2024
University of Science and Technology of China
2021-2023
Hefei National Center for Physical Sciences at Nanoscale
2021
Lanzhou University
2020
Ministry of Civil Affairs
2020
Xi'an Jiaotong University
2020
Hangzhou First People's Hospital
2018
Wuhan University of Technology
2013
Community of antibodies against COVID-19 The severe acute respiratory syndrome coronavirus 2 spike protein is the basis many vaccines and a primary target neutralizing after infection. Coronavirus Immunotherapeutic Consortium (CoVIC), comprising 56 partners across world, has analyzed panel 269 monoclonal (mAbs) and, on competition profiles, sorted 186 mAbs that receptor binding domain into seven communities. Hastie et al . went to structurally analyze representative antibody used pseudovirus...
Abstract GABA A receptors (GABA Rs) are the primary fast inhibitory ion channels in central nervous system. Dysfunction of trafficking and localization Rs to cell membranes is clinically associated with severe psychiatric disorders humans. The GABARAP protein known support stability synapses, but underlying molecular mechanisms remain be elucidated. Here, we show that GABARAP/GABARAPL1 directly binds a previously unappreciated region γ2 subunit R. We demonstrate functions stabilize via...
Abstract E-cadherin is an essential cell‒cell adhesion protein that mediates canonical cadherin-catenin complex formation in epithelial lateral membranes. Ankyrin-G (AnkG), a scaffold linking membrane proteins to the spectrin-based cytoskeleton, coordinates with maintain cell polarity. However, molecular mechanisms governing this and its relationships remain elusive. Here, we report AnkG employs promiscuous manner encapsulate three discrete sites of by same region, dynamic mechanism distinct...
Non-coding RNAs are fundamental to the competing endogenous RNA (CeRNA) hypothesis in oncology. Previous work focused on static CeRNA networks. We construct and analyze networks for four sequential stages of lung adenocarcinoma (LUAD) based multi-omics data long non-coding (lncRNAs), microRNAs mRNAs. find that possess a two-level bipartite structure: common network (CCEN) composed an invariant set over all stage-dependent, unique (UCENs). A systematic enrichment analysis pathways mRNAs CCEN...
Paravertebral muscles (PVM) degeneration (PMD) is closely associated with low back pain. Muscle stem cells (MuSCs) can promote muscle regeneration and repair. However, our understanding of the cellular composition PVM key genes-mediated MuSCs functions limited. We analyzed heterogeneity identified genes using scRNA-seq. To validate presence EGR1 + MuSCs, we performed Flow cytometry assays. utilized pseudo-time, CytoTRACE, RNA velocity to reconstruct differentiation trajectory. CellPhoneDB...
A prominent endophenotype in Autism Spectrum Disorder (ASD) is the synaptic plasticity dysfunction, yet molecular mechanism remains elusive. As a prototype, we investigate postsynaptic signal transduction network glutamatergic neurons and integrate single-cell nucleus transcriptomics data from Prefrontal Cortex (PFC) to unveil malfunction of translation control. We devise an innovative highly dependable pipeline transform our acquired into mRNA Signaling-Regulatory Network (mSiReN) analyze...
Abstract A prominent endophenotype in Autism Spectrum Disorder (ASD) is synaptic plasticity dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigated postsynaptic signal transduction network glutamatergic neurons and integrated transcriptomics to unveil malfunction of translation control. We devised an innovative highly dependable pipeline transform our acquired into mRNA Signaling-Regulatory Network (mSiReN) analyze it at RNA level. employed Cell-Specific...
Nowadays, the rapid development of technology research and trend increasingly fierce competition change market economy organization form enterprise. In order to survive develop, many companies have started cooperate with each other. As enterprise developing at a high speed, failure rate is also worthy our attention. Many risks will emerge in process cooperative innovation relation risk one them. this paper, through empirical analysis, effect for team performance be illustrated. addition,...
Lactic acid bacteria (LAB) are food-grade,generally regarded as safe microorganisms.Effective immune responses can be induced using LAB expression vectors for antigen expression.Oral and intranasal immunizations also induce mucosal response.They easy to operate have better efficacy compliance than those achieved by traditional injective way.In the present review,we describe advantages of vectors,various delivery systems developed LAB,successfully expressed heterologous proteins,and a novel...