A5083861011- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- Health and Lifestyle Studies
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Parasitic Diseases Research and Treatment
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- SARS-CoV-2 and COVID-19 Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Advertising and Communication Studies
- Diet and metabolism studies
- Immunodeficiency and Autoimmune Disorders
- Apelin-related biomedical research
- Cardiovascular Disease and Adiposity
- Journalism and Media Studies
- Microbial infections and disease research
- Blood Pressure and Hypertension Studies
- Communication and COVID-19 Impact
Twist Bioscience (United States)
2020-2024
University of Cundinamarca
2024
Montclair State University
2023
University of San Carlos of Guatemala
2020
Hospital Universitario Nuestra Señora de Candelaria
2008-2014
Research Network (United States)
2014
Instituto de Salud Carlos III
2013
Canary Institute of Cancer Research
2008-2010
Hospital San Juan de la Cruz
2008
Universidad de La Laguna
2008
Community of antibodies against COVID-19 The severe acute respiratory syndrome coronavirus 2 spike protein is the basis many vaccines and a primary target neutralizing after infection. Coronavirus Immunotherapeutic Consortium (CoVIC), comprising 56 partners across world, has analyzed panel 269 monoclonal (mAbs) and, on competition profiles, sorted 186 mAbs that receptor binding domain into seven communities. Hastie et al . went to structurally analyze representative antibody used pseudovirus...
Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in control human immunodeficiency virus (HIV) disease progression exist. We present generated from a Peruvian cohort untreated, clade B-infected subjects, demonstrating that proportion Gag-specific, particular p24-reactive, CTL among virus-specific activity is associated with individuals' CD4 counts viral loads. Analyses second United States confirm these findings point towards dominant...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce several vascular endothelial-dependent systemic complications, and sulodexide has pleiotropic actions on the endothelium, which prove beneficial. We aimed to assess effect of when used within 3 days disease 2019 (COVID-19) clinical onset. conducted a randomized placebo-controlled outpatient trial. To be included, patients must have been at high risk for severe progression. Participants received (oral 1,000...
Fundamento: Canarias ocupa el primer lugar de España en mortalidad por cardiopatía isquémica y diabetes. Sus mujeres son las primeras cáncer mama. El "CDC Canarias" es estudio una cohorte población general para analizar la prevalencia e incidencia estas enfermedades exposición a sus factores riesgo (FR) adulta del archipiélago. Métodos: Estudio prospectivo con muestreo aleatorio general, que participaron 6.729 personas entre los años 2000 2005 (edad 18-75 años). Se les realizó antropometría...
To estimate the incidence rate and risk factors for diabetes in Canary Islands.A total of 5521 adults without were followed a median 3.5 years. Incident cases self-declared validated medical records. The following assessed by Cox regression to hazard ratios diabetes: impaired fasting glucose (5.6 mmol/l ≤ 6.9 mmol/l), BMI, waist-to-height ratio (≥ 0.55), insulin resistance (defined as triglycerides/HDL cholesterol ≥ 3), familial antecedents diabetes, Canarian ancestry, smoking, alcohol...
Aims: The serum resistin level is associated with the incidence of ischemic heart disease in general population. We analyzed associations between and fat intake, lipid concentrations adiposity Methods: A cross-sectional study 6,637 randomly recruited adults was conducted. levels were measured thawed aliquots using an enzyme immunoanalysis technique. Results: exhibited a positive nonparametric correlation saturated intake(p<0.001) inverse adherence to Mediterranean diet(p<0.001),...
Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis in need of therapeutic options. Passive immunization monoclonal antibodies (mAbs) represents a promising strategy capable conferring immediate protection from SARS-CoV-2 infection. Herein, we describe the discovery and characterization neutralizing IgG VHH four large-scale phage libraries. Each library was constructed synthetically with shuffled complementarity-determining region loops natural llama human antibody...
The Canary Islands population experiences the highest type 2 diabetes (DM2) mortality in Spain. We studied lifestyle, unknown DM2 and treatment adherence diabetics of these islands.Cross-sectional study 6729 subjects from general (age 18-75) that participate cohort "CDC Islands". found out their medical problems, diet, physical activity, medications, smoking, etc.Prevalence was 12% men 10% women (p=0.005). disease 22% 9% (p < 0.001). Considering DM2, lack adherence, 48% 28% did not follow a...
To explore the association between resistin expression and incidence of ischemic heart disease in general population.A follow-up study 6636 adults recruited randomly from population.The serum concentration was higher women (6.1 ng/mL; CI95%=6.0-6.2) than men (5.6 CI95%=5.5-5.7). Individuals 5th quintile or (RQ5) were younger (P＜0.001) had a lower prevalence arterial hypertension (P＜0.001), abdominal obesity diabetes dyslipidemia (P＜0.001). The cardiovascular risk estimated by Framingham...
G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies becoming an increasingly promising modality target these due their unique properties, such as exquisite specificity, long half-life, and fewer side effects, improved pharmacokinetic pharmacodynamic profiles compared peptides small molecules, which results from more favorable biodistribution. To date, there only two US Food Drug...
New immune checkpoints are emerging in a bid to improve response rates immunotherapeutic drugs. The adenosine A 2A receptor (A R) has been proposed as target for development due its participation immunosuppression of the tumor microenvironment. Blockade R could restore immunity and, consequently, patient outcomes. Here, we describe discovery potent, selective, and tumor-suppressing antibody antagonist human (hA by phage display. We constructed screened four single-chain variable fragment...
Nanobodies are essential proteins of the adaptive immune systems camelid and shark species, complementing conventional antibodies. Properties such as their relatively small size, solubility high thermostability make VHH (variable heavy domain chain) VNAR new antigen receptor) modalities a promising therapeutic format valuable resource for wide range biological applications. The volume academic literature patents related to nanobodies has risen significantly over past decade. Here, we present...
Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion excessive and results hypoglycemia that, without treatment, can cause brain damage or death. Most patients with loss-of-function mutations ABCC8 KCNJ11, the genes encoding ATP-sensitive potassium channel (KATP), are unresponsive to diazoxide, only U.S. Food Drug Administration–approved medical therapy require pancreatectomy. The glucagon-like peptide 1 receptor (GLP-1R) antagonist...
Background: Targeting endothelial cells has been suggested for the treatment of patients with COVID-19 and sulodexide pleiotropic properties within vascular endothelium that can prove beneficial to same. We aimed evaluate effect when used in early clinical stages COVID-19. Methods: conducted a single-centre, outpatient setting, randomized controlled trial parallel-group design Mexico. Including three days symptom onset, who were at high risk severe progression due chronic comorbidities....
There is evidence that androgens are regulators of insulin resistance (IR), and may be involved in the regulation resistin, a cytokine has been related with IR. Earlier studies found androgen receptor length polymorphisms CAGn GGNn aromatase polymorphism TTTAn influence or enzyme activity serum concentrations androgens. This study was designed to determine whether resistin concentration other variables In 1,580 persons chosen randomly from general population Canary Islands (Spain), we...