A5076715418- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- Reproductive tract infections research
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- HIV/AIDS oral health manifestations
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Syphilis Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Indigenous Studies and Ecology
- Parkinson's Disease Mechanisms and Treatments
- Research on Leishmaniasis Studies
- Urinary Tract Infections Management
- Indigenous Health and Education
- HIV, Drug Use, Sexual Risk
- Bacillus and Francisella bacterial research
- Oral and gingival health research
- Genital Health and Disease
- Long-Term Effects of COVID-19
Universidad Continental
2023
Peruvian University of Applied Sciences
2017-2023
Ministry of Health
2023
Hospital Nacional Cayetano Heredia
2019-2020
Asociación Civil Impacta Salud y Educación
2003-2015
Naval Medical Research Command
2009
Fogarty International Center
2009
United States Agency for International Development
2009
University of Bergamo
1977
Conflicting data on the role of total virus- and protein-specific cytotoxic-T-lymphocyte (CTL) responses in control human immunodeficiency virus (HIV) disease progression exist. We present generated from a Peruvian cohort untreated, clade B-infected subjects, demonstrating that proportion Gag-specific, particular p24-reactive, CTL among virus-specific activity is associated with individuals' CD4 counts viral loads. Analyses second United States confirm these findings point towards dominant...
Herpes simplex virus type 2 (HSV-2) infection is common among human immunodeficiency (HIV)-infected persons, and HSV reactivation increases plasma genital HIV-1 levels. We studied levels during suppression in coinfected persons a placebo-controlled crossover trial.Twenty antiretroviral therapy (ART)-naive HIV-1/HSV-2-seropositive men who have sex with Lima, Peru, CD4 cell counts >200 cells/ microL were randomized to receive either valacyclovir at 500 mg twice daily or placebo for 8 weeks,...
A randomized cross-over trial of herpes simplex virus type 2 (HSV-2)-suppressive therapy (valacyclovir, 500 mg twice daily, or placebo for 8 weeks, a 2-week washout period, then the alternative weeks) was conducted among 20 Peruvian women coinfected with HSV-2 and human immunodeficiency 1 (HIV-1) who were not on antiretroviral therapy. Plasma samples (obtained weekly) endocervical swab specimens thrice collected HIV-1 RNA polymerase chain reaction. level significantly lower during...
Objective: To assess and estimate trends in HIV, sexually transmitted infections (STIs), sexual behavior among men who have sex with (MSM) Lima, Peru. Design: Second-generation HIV sentinel surveillance surveys conducted 1996, 1998, 2000, 2002. Methods: Adult reporting at least 1 man during the previous year were eligible to participate. Sexual serum HIV-1 syphilis antibodies assessed. seroincidence was estimated by a sensitive/less-sensitive enzyme immunoassay strategy. Rectal pharyngeal...
Monkeypox (Mpox) recent outbreak has changed in terms of predominant transmission route and typical presentation. Describing current epidemiological clinical characteristics is crucial to identifying cases halting transmission.An observational study was conducted at a Peruvian tertiary-level hospital included all individuals with Mpox virus infection between July 01 September 03, 2022.Among 205 confirmed cases, 99% (202/205) were men, 94% (192/205) men who have sex or bisexual, 66% (136/205)...
BackgroundWe evaluated associations between human immunodeficiency virus (HIV) infection, herpes simplex type 2 (HSV-2) and syphilis among men who have sex with (MSM) in Peru MethodsA surveillance survey of 3280 MSM was conducted; sexual behavior assessed a structured computer-assisted self-interview, serum antibody testing performed for HIV, HSV-2, Treponema pallidum ResultsHIV, seroprevalences 13.9%, 46.3%, 13.4% were detected, respectively. HSV-2 seroprevalence twice as high HIV-infected...
Background: In the Andean Region, HIV and sexually transmitted infections (STI) are most prevalent among men who have sex with (MSM), but incidence estimates associated factors never been prospectively assessed. Methods: A cohort of 1056 high-risk HIV-negative MSM in Lima, Peru, were recruited during 1998-2000 (the ALASKA Cohort), a nested case-control analysis was conducted between seroconverters nonseroconverters, matched 1:3 by age duration follow-up for comparison risk behaviors, acute...
High levels of human immunodeficiency virus (HIV) in rectal secretions and semen likely increase the risk HIV transmission. HIV-infected men who have sex with made 2-3 study visits, over 4 weeks, to assess rectal, seminal, plasma RNA. Mixed-effects models estimated effect factors on shedding. Twenty-seven (42%) 64 were receiving antiretroviral therapy (ART); regardless ART use, median RNA higher (4.96 log(10) copies/mL) than blood (4.24 or seminal (3.55 copies/mL; P<.05, each comparison)....
Suppressive herpes simplex virus (HSV) therapy can decrease plasma, cervical, and rectal HIV-1 levels in HIV-1/HSV-2 co-infected persons. We evaluated the effect of HSV-2 suppression on seminal levels.Twenty antiretroviral (ART)-naive men who have sex with (MSM) Lima, Peru, CD4 >200 cells/microl randomly received valacyclovir 500 mg twice daily or placebo for 8 weeks, then alternative regimen weeks after a 2-week washout. Peripheral blood semen specimens were collected weekly. Anogenital...
The objective of this study is to identify human leukocyte antigen (HLA) class I and killer-cell immunoglobulin-like receptor (KIR) genotypes associated with different risks for HIV acquisition disease progression.A cross-sectional a cohort 468 high-risk individuals (246 HIV-positive 222 HIV-negative) from outpatient clinics in Lima (Perú).The was high-resolution HLA KIR-typed analysed potential differences single-allele frequencies allele combinations between HIV-negative associations viral...
Objective: To evaluate the recognition of computationally designed, centralized HIV-1 antigens derived from clade B, C and group M sequences by individuals infected with HIV-1-M clades B C. Methods: Three have been described – consensus, ancestor center-of-tree each which attempts to minimize genetic distance circulating viruses. It is unclear whether any these affords an advantage for T cell recognition. The ability peptides be targeted in ELISpot assays was assessed using samples United...
Abstract Objective To assess the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis for prevention SARS-CoV-2 infection in healthcare workers (HCW) on duty during COVID-19 pandemic. Results A total 68 HCWs met eligibility criteria were randomly allocated to receive HCQ (n = 36) or not 32). There no significant differences between groups respects age, gender, medical history. Eight participants primary efficacy endpoint SAR-CoV-2 study period; there was difference incidence...
Orogenital transmission of human immunodeficiency virus (HIV) is considered to be inefficient, and infectious HIV rarely detected in saliva. To evaluate the posterior oropharynx as a source shedding, we studied 64 HIV-infected men who have sex with Seattle, Washington, Lima, Peru. In multivariate analysis, receipt antiretroviral therapy, higher CD4 cell count, history tonsillectomy were predictors lower pharyngeal RNA levels.
Objective: This study aimed to evaluate the association between intensity of menopausal symptoms and highly active antiretroviral therapy (HAART) adherence in middle-aged women with human immunodeficiency virus (HIV) infection.Methods: In this cross-sectional study, 313 Peruvian HIV infection (age 40-59 years) were surveyed classified as adherent or non-adherent HAART based on Antiretroviral Treatment Adherence Evaluation Questionnaire. The was assessed Menopause Rating Scale, categorized...
ABSTRACT We tested rectal specimens from men who have sex with for Chlamydia trachomatis by using COBAS PCR (Roche Diagnostics) and ligase chain reaction LCR (Abbott laboratories) compared three specimen-processing procedures. Chlamydiae were detected one or more procedures in 22 of 186 specimens. All tests positive 17 specimens, all which also LCR.
Introducción La principal causa de muerte en pacientes infectados con VIH es la tuberculosis (TBC). Pocos estudios latinoamericanos han evaluado sobrevida co-infectados.
Abstract Objective To evaluate the association between Highly Active Antiretroviral Therapy (HAART) discontinuation time and therapeutic failure (TF) in Venezuelan immigrants with HIV that restart HAART. Methods We carried out a retrospective cohort study large hospital Peru. included who restarted HAART were followed over at least 6 months. The primary outcome was TF. Secondary outcomes immunologic (IF), virologic (VF) clinical (CF) failures. exposure variable discontinuation, categorised...
We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located Andean valleys Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions on inferior abdomen, lumbar region and right anterior thigh. Histological analysis found leishmanial amastigotes lesion sample, Montenegro reaction was positive for Leishmania spp, polymerase chain peruviana. In conclusion, presentation this disease may be related to presence uncommon...
Introduction: In patients with HIV in antiretroviral treatment (ART) and virological failure to the first-line regimen, establishing a therapeutic regimen after having identified M184V mutation, which confers ART resistance, represents dilemma. Objective: To compare response of regimens prescribed who presented mutation two national hospitals Lima, Peru, during years 2008 2019, determine risk factors associated poor response. Methods: A retrospective cohort study was developed based on...