A5077728410- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Genomics and Phylogenetic Studies
- Wnt/β-catenin signaling in development and cancer
- Probiotics and Fermented Foods
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related gene regulation
- Synthesis and bioactivity of alkaloids
- RNA Research and Splicing
- Drug Transport and Resistance Mechanisms
- Reproductive tract infections research
- Bacterial Genetics and Biotechnology
University of Iowa
2021-2025
University of Illinois Urbana-Champaign
2021-2024
Harvard University
2024
Human gut microbiome composition is constantly changing, and diet a major driver of these changes. Gut microbial species that persist in mammalian hosts for long periods time must possess mechanisms sensing adapting to nutrient shifts avoid being outcompeted. Global regulatory mediated by RNA-binding proteins (RBPs) govern responses have been characterized Proteobacteria Firmicutes but remain undiscovered the Bacteroidetes. Here, we report identification RBPs are broadly distributed across...
Abstract Bacteroides species are successful colonizers of the human gut and can utilize a wide variety complex polysaccharides oligosaccharides that indigestible by host. To do this, they use enzymes encoded in Polysaccharide Utilization Loci (PULs). While recent work has uncovered PULs required for some polysaccharides, how smaller is less well studied. Raffinose family (RFOs) abundant plants, especially legumes, consist variable units galactose linked ⍺-1,6 bonds to sucrose (glucose...
ABSTRACT Bacteroides species are successful colonizers of the human colon and can utilize a wide variety complex polysaccharides oligosaccharides that indigestible by host. To do this, they use enzymes encoded in polysaccharide utilization loci (PULs). While recent work has uncovered PULs required for some polysaccharides, how smaller is less well studied. Raffinose family (RFOs) abundant plants, especially legumes, consist variable units galactose linked α-1,6 bonds to sucrose (glucose...
Abstract Human gut microbiome composition is constantly changing, and diet a major driver of these changes. Gut microbial species that persist in mammalian hosts for long periods time must possess mechanisms sensing adapting to nutrient shifts avoid being outcompeted. Global regulatory mediated by RNA-binding proteins (RBPs) govern responses have been characterized Proteobacteria Firmicutes but remain undiscovered the Bacteroidetes. Here we report identification RBPs are broadly distributed...
Abstract β-catenin is a multifunctional protein capable of mediating cell adhesion via E-cadherin and transactivation target genes the canonical Wnt signaling pathway. The nematode, C. elegans contains four paralogs which are highly specific in their functions. Though similar overall structure, beta-catenins functionally distinct, each regulating different aspects development. Of four, SYS-1 key player dependent asymmetric division (ACD). In ACD, polarized mother will give rise to daughter...