A5061704816- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Conducting polymers and applications
- Neonatal and fetal brain pathology
- Hemoglobin structure and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Memory and Neural Computing
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
Kazan Federal University
2016-2024
Abstract Functional coupling live neurons through artificial synapses is the primary requirement for their implementation as prosthetic devices or in building hybrid networks. Here, first evidence of unidirectional, activity dependent, two brain slices via organic memristive (OMD) demonstrated. ODM a polymeric electrochemical element, which has terminals connection electrical circuits and displays hysteresis rectifying features. OMD characterized by nonlinear relationships determined...
Anoxic spreading depolarization (aSD) has been hypothesized as a terminal event during oxygen-glucose deprivation (OGD) in submerged cortical slices vitro. However, mechanical artifacts caused by aSD-triggered edema may introduce error the assessment of neuronal viability. Here, using continuous patch-clamp recordings from rat slices, we first confirmed that vast majority L4 neurons permanently lost their membrane potential OGD-induced aSD. In some recordings, spontaneous transition...
Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD associated with spreading wave neuronal and an increase in light transmittance. However, initiation spread across the layers somatosensory cortex, which one most frequently affected regions stroke, remains largely unknown. Here, we explored propagation slices rat barrel cortex using extracellular local field potential (LFP) recordings optical intrinsic signal (OIS) recordings. We found that ischemia-like conditions induced...
Anoxic spreading depolarization (aSD) is a hallmark of ischemic injury in the cerebral cortex. In adults, aSD associated with rapid and nearly complete neuronal loss functions. While ischemia also evokes immature cortex, developmental aspects behavior during remain largely unknown. Here, using oxygen-glucose deprivation (OGD) model slices postnatal rat somatosensory we found that neurons displayed much more complex behaviors: they initially moderately depolarized aSD, then transiently...
Cerebral edema is a major, life threatening complication of ischemic brain damage. Previous studies using slices have revealed that cellular swelling and concomitant increase in tissue transparency starts within minutes the onset metabolic insult association with collective anoxic spreading depolarization (aSD). However, dynamics under ischemia-like conditions remain elusive. Here, we explored induced by oxygen-glucose deprivation (OGD) submerged rat barrel cortex slices. Video monitoring...
During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and firing of pyramidal cells followed afterhyperpolarization (GDP-AHP). Here, we explored the properties GDP-AHP in using gramicidin perforated patch clamp recordings from neonatal rat slices. We found that occurs independently whether fire action potentials (APs) or remain silent during GDPs. However,...
In the present study we explored neuronal survival during oxygen-glucose deprivation (OGD) in slices of barrel cortex using whole-cell patch clamp recordings and concomitant extracellular local field potential (LFP) ,and optical intrinsic signal (OIS). To this aim used two types assessment. first approach, performed continuous from a single neuron starting control conditions then through OGD reperfusion. second sampled cells short-term patch-clamp reperfusion following various durations...