A5063272954- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- HVDC Systems and Fault Protection
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Anesthesia and Pain Management
- Neuroblastoma Research and Treatments
- Surgical Sutures and Adhesives
- Lung Cancer Diagnosis and Treatment
- Climate Change and Health Impacts
- Urological Disorders and Treatments
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Surgical site infection prevention
- Cancer Cells and Metastasis
- Pelvic floor disorders treatments
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Urinary and Genital Oncology Studies
- COVID-19 and healthcare impacts
Nanjing Medical University
2019-2025
Jiangsu Province Hospital
2019-2025
Nanjing General Hospital of Nanjing Military Command
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
METTL3 is known to be involved in all stages the life cycle of RNA. It affects tumor formation by regulation m6A modification mRNAs critical oncogenes or suppressors. In bladder cancer, could promote cancer progression via AFF4/NF-κB/MYC signaling network an dependent manner. Recently, was also found affect non-coding RNAs including miRNAs, lincRNAs and circRNAs. However, whether this mechanism related proliferation tumors induced not reported yet. Quantitative real-time PCR, western blot...
N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role various physiological events. AlkB homolog 5 demethylase (ALKBH5), m6A demethylase, belongs family of dioxygenases has been shown specifically demethylate RNA, which associated with a variety tumors. However, its function bladder cancer remains largely unclear. In present study, we that expression ALKBH5 was downregulated tissues cell lines. Low...
N6-methyladenosine (m6A) is important in the physiological processes of many species.Methyltransferase-like 16 (METTL16) a novel discovered m6A methylase, regulating various tumors an m6A-dependent manner.However, its function bladder cancer (BLCA) remains largely unclear.In present study, we found that low expression METTL16 predicted poor survival BLCA patients.METTL16 inhibited proliferation and cisplatin-resistance cells vitro vivo.In addition, reduced mRNA stability prostate...
The modification and regulation of N6-methyladenosine (m6A) at mRNA level can affect the development progression in various tumors. ALKBH5, as an m6A demethylase, plays different roles tumors by regulating mRNA. However, its role renal cell carcinoma (RCC) remains unclear.First, levels ALKBH5 RCC tissues lines were verified qRT-PCR western blot. We analyzed relationship between clinicopathological characteristics patients influence on prognosis patients. Then we generated...
Cisplatin-based chemotherapy is a primary treatment for bladder cancer, yet the development of chemoresistance poses significant therapeutic challenge. Insulin-like growth factor II mRNA binding protein 3 (IGF2BP3) an RNA-binding and key m6A reader that regulates various cancers through m6A-dependent mechanisms. However, its role in resistance cancer remains unclear. Our vivo vitro experiments identified IGF2BP3 as regulator cisplatin cancer. We demonstrated enhances stability CDK6 manner,...
To investigate the role of circulating rare cells (CRCs), namely, tumor (CTCs) and endothelial (CECs), in aiding early intervention, treatment decision, prognostication bladder cancer. A total 196 patients with pathologically confirmed cancer, 141 non-muscle invasive cancer (NMIBC) 55 muscle (MIBC) patients. There were 32 who received cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC). Subtraction enrichment combined immunostaining-fluorescence situ...
Abstract Background Melanoma is an extremely aggressive type of skin cancer and experiencing a expeditiously rising mortality in current year. Exploring new potential prognostic biomarkers therapeutic targets melanoma are urgently needed. The ambition this research was to identify genetic markers assess performance N6-methyladenosine (m6A) regulators melanoma. Methods Gene expression data corresponding clinical informations patients as well sequence normal controls collected from Cancer...
Abstract Background To investigate whether Pentafecta is suitable for bladder cancer patients receiving laparoscopic radical cystectomy (LRC). Methods From November 2013 to December 2020, muscle invasive Bladder Cancer (MIBC) and non-muscle (NMIBC) who received LRC urinary diversion were retrospectively analyzed. was defined as meeting five criteria: negative soft margin, ≥ 16 lymph nodes (LNs) removed, major complications free, related sequelae free clinical recurrence within 1 year....
Dear Editor,The coronavirus disease-2019 (COVID-19) pandemic in early 2020 has caused great global damage to health-care systems. The Chinese government announced a stop travel and out of Wuhan, Hubei Province, on January 23, 2020, control the spread virus. As July 14, number confirmed cases globally increased 12,964,809 [1]. Defeating COVID-19 requires joint efforts worldwide.Hematuria often occurs as an symptom bladder cancer. However, most people do not pay attention this warning sign,...
In recent years, increasing evidence shows that circular RNA (circRNA) disorder is closely related to tumorigenesis and cancer progression. However, the regulatory functions of most circRNAs in bladder (BCa) remain unclear. This study was aimed at exploring molecular mechanism BCa. We obtained four datasets circRNA, microRNA (miRNA), messenger (mRNA) expression profiles from Gene Expression Omnibus The Cancer Genome Atlas microarray databases identified 434, 367, 4799/4841 differentially...
Abstract Background: Circular RNAs (circRNAs) are noncoding that have the structure of a covalently closed loop. Increasing data has proved circRNA can influence development and progression tumors. CircFAM114A2 is generated from several exons FAM114A2. However, function mechanisms circFAM114A2 in bladder cancer (BCa) remain unclear. This research aimed to reveal inhibits improves sensitivity cisplatin chemotherapy by inducing G1/S cell cycle arrest via novel miR-222-3p/P27 miR-146a-5p/P21...