A5003868429- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- Genital Health and Disease
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ureteral procedures and complications
- Nanoplatforms for cancer theranostics
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Tuberous Sclerosis Complex Research
- Genomics, phytochemicals, and oxidative stress
- Kidney Stones and Urolithiasis Treatments
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Renal and Vascular Pathologies
- Clusterin in disease pathology
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Henan University of Traditional Chinese Medicine
2023
Hunan University
2022
Southwest Jiaotong University
2019
Zhengzhou City Hospital
2018
Iowa City Public Library
2016
Capital Medical University
2012
Jiangsu Shengze Hospital
2011
Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as sponge for certain miRNAs targeting their parental transcripts ITCH. However, the role circ-ITCH in bladder cancer (BCa) was not reported. In present study, we investigated BCa. Quantitative real-time PCR used to detect expression survival analysis adopted explore association between prognosis BCa cells were stably transfected with lentivirus approach cell...
Abstract BACKGROUND Castration‐resistant prostate cancer (CRPC) is a leading cause of cancer‐related deaths in elder men. This disease has limited therapeutic options and poor prognosis as the underlying molecular mechanisms are not clearly understood. Given emerging roles microRNA (miRNA) key regulator, we postulated that miRNA may play significant role CRPC formation. METHODS miR‐146a levels 15 androgen‐dependent (ADPC) tissues 5 were measured by qRT‐PCR. Effects cell proliferation...
Graphene oxide (GO) exhibits excellent adsorption ability to remove organic dyes from liquid; therefore, fabricating GO-based adsorbents has attracted increasing interest researchers. However, it is still challenging prepare the with high structure stability while simultaneously maintaining its ability. In this work, a novel one-step fabrication method combining exfoliating and micro-cross-linking was proposed GO composite aerogel globules, in which exfoliated by carboxymethyl cellulose...
Abstract MicroRNAs (miRNAs), abundant and highly stable in the plasma, have been widely reported. This greatly pursued us to investigate whether plasma miRNAs could be considered as powerful biomarkers for diagnosing bladder cancer (BC). We performed a profile with TaqMan Low Density Array two-phase validation detect candidate expression by quantitative PCR. The receiver operating characteristic curve (ROC) area under (AUC) were used evaluate diagnostic accuracy. A total of eight abnormally...
Cancer cells exhibit the ability to metabolise glucose lactate even under aerobic conditions for energy. This phenomenon is known as Warburg effect and can be a potential target kill cancer cells. Several studies have shown evidence interplay between microRNAs key metabolic enzyme effecters, which facilitate in In present study, microRNA sponge forcibly expressed using lentiviral vector was utilised knock down miR-21 expression vitro. qPCR Western blot assays were performed evaluate of...
Background/Aims: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed investigate the radiosensitizing effect of chloroquine in bladder cancer, with emphasis on autophagy inhibition and apoptosis induction. Methods: Bladder cancer cell lines were irradiated or without chloroquine. Cell proliferation determined by a Counting Kit 8 assay. The radiosensitization evaluated clonogenic survival progression...
Background/Aims: MicroRNA-218 (miR-218) is down-regulated in many malignancies that have been implicated the regulation of diverse processes cancer cells. However, involvement miR-218 chemo-sensitivity to cisplatin and precise mechanism this action remained unknown bladder cancer. Methods: qRT-PCR was used detect its target Glut1 expression cell lines T24 EJ. CCK-8 method utilized measure viability. IC 50 calculated via a probit regression model. detected by western blotting for analysis...
Abstract BACKGROUND To explore the reported association of SNP marker rs10993994 with prostate cancer identified by two independent in genome‐wide studies (GWAS) further, we performed a case–control study southern Chinese Han population. Consequently, detected serum levels MSMB expression different genotypes cases and controls to characterize functional consequences rs10993994. MATERIALS AND METHODS Two hundred fifty‐one 258 control subjects were included 90 samples used test Enzyme‐linked...
MicroRNAs (miRNAs) are recognized as important molecules and have emerged gene regulators in tumorigenesis. Growing evidence suggested that miR-218 was a tumor suppressor many human cancers. However, its underlying role bladder cancer (BCa) remains unclear. The aim of this study to explore the effect on proliferation, migration, invasion BCa cells. We found frequently downregulated tissues compared with normal adjacent tissues. In vitro vivo assays demonstrated overexpression cells inhibited...
Photodynamic therapy (PDT) is often applied in a clinical setting to treat bladder cancer. However, current photosensitizers report drawbacks such as low efficacy, selectivity, and numerous side effects, which have limited the values of PDT for Previously, we developed first cancer-specific aptamer that can selectively bind be internalized by tumor cells versus normal uroepithelium cells. Here, use an aptamer-based drug delivery system deliver photosensitizer chlorine e6 (Ce6) into In...
To develop a deep learning (DL) model based on MRI to predict muscle-invasive bladder cancer (MIBC). A total of 559 patients, including 521 patients in our center and 38 external centers were collected from 2012 2023 construct the DL model. In this study, was utilized differentiate between MIBC NMIBC three-channel image inputs, original T2WI images, segmented bladder, regions interest. Inception V3 employed for construction. The accuracy, sensitivity (SN), specificity (SP), positive...
Abstract Bladder cancer is common worldwide, with most patients presenting nonmuscle invasive disease. Multiple intravesical recurrences lead to reduced quality of life and high costs for this form bladder cancer. Intravesical chemotherapy aimed at reducing recurrence the standard-of-care but has significant side effects from nonspecific cytotoxicity normal urothelium. Importantly, toxicity limits doses that can be administered. Thus, tumor-specific drug targeting could reduce enhance...
To investigate the role of circulating rare cells (CRCs), namely, tumor (CTCs) and endothelial (CECs), in aiding early intervention, treatment decision, prognostication bladder cancer. A total 196 patients with pathologically confirmed cancer, 141 non-muscle invasive cancer (NMIBC) 55 muscle (MIBC) patients. There were 32 who received cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC). Subtraction enrichment combined immunostaining-fluorescence situ...
Background Bladder cancer is a common disease worldwide with most patients presenting the non-muscle-invasive form (NMIBC) at initial diagnosis. Postoperational intravesical instillation of BCG carried out for high-risk to reduce tumor recurrence and progression muscle invasive disease. However, can also have side effects or be ineffective in some because it cannot enter cells. Thus, improve efficacy immunotherapy long-term pursuit bladder field. Methods To increase adhesion urothelium we...
Objective To investigate the efficacy and safety of transurethral seminal vesiculoscopy in diagnosis treatment intractable vesiculitis. Methods This prospective observational study enrolled patients with The vesiculoscope was inserted into bilateral ejaculatory ducts vesicles, via urethra. vesicles were visualized to confirm vesiculitis determine cause disease. washed repeatedly using 0.90% (w/v) sodium chloride before a 0.50% levofloxacin solution injected vesicles. Results A total 114...
Background A functional -94 insertion/deletion polymorphism (rs28362491) in the promoter of NFKB1 gene was reported to influence expression and confer susceptibility different types cancer. This study aims determine whether is associated with risk bladder Materials methods TaqMan assay used genotype among 609 cases 640 controls a Chinese population. Logistic regression assess association between cancer risk, quantitative real-time polymerase chain reaction mRNA expression. Results Compared...
Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression many tumors presents dual roles bladder cancer (BC). Therefore, definite miR-200c BC needs to be investigated further.Quantitative reverse transcription polymerase chain reaction was used assess expression. Cell invasion migration were evaluated using wound healing transwell assays. The luciferase reporter assay identify...
Numerous patients with muscle-invasive bladder cancer develop low responsiveness to cisplatin. Our purpose was explore differential metabolites derived from serum in treated neoadjuvant chemotherapy (NAC). Data of diagnosed cT2-4aNxM0 collected. Blood samples were retained prospectively before the first for untargeted metabolomics by 1H-NMR and UPLC-MS. To identify characterized metabolites, multivariate statistical analyses applied, intersection discovered two approaches used viable...
Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVES • To investigate a new method vas deferens radiography for ejaculatory duct obstruction (EDO). evaluate the effect procedure involving dilation by F9 seminal vesicoscopy. PATIENTS AND METHODS Twenty‐two patients with EDO were diagnosed using semen analysis, fructose measurement, transrectal ultrasonography (TRUS) and radiography. Of these, 18 successfully treated vesicoscopy four patients, whose treatment was unsuccessful,...