A5020183752- Hepatitis C virus research
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Vitamin D Research Studies
- Glutathione Transferases and Polymorphisms
- Parathyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- T-cell and B-cell Immunology
- Regulation of Appetite and Obesity
- Genetic and Kidney Cyst Diseases
- Genetic Associations and Epidemiology
- Thyroid and Parathyroid Surgery
- Alcohol Consumption and Health Effects
- Cell death mechanisms and regulation
- Respiratory viral infections research
- Paraoxonase enzyme and polymorphisms
- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
National Research Centre
2012-2022
National Water Research Center
2012
We studied JAZF1, ABCC8, KCNJ11and Notch2 gene expression and vitamin D receptor (VDR) polymorphisms (Fok1 Bsm1) in patients with type 2 diabetes mellitus (T2DM) tried to find out their association microvascular complications these patients.The study was conducted on 180 (93 complicated 87 noncomplicated) 150 healthy subjects. Reverse-transcriptase polymerase chain reaction (RT-PCR) used assess real-time PCR detect VDR genotypes. Serum assessed using Elisa technique.After adjustment for age,...
Non-alcoholic fatty liver disease (NAFLD) is a condition defined by significant lipid accumulation (5–10%) in hepatic tissue the absence of chronic alcohol consumption. We aim to detect frequency among overweight/obese adults and children associated clinical; anthropological measures; biochemical; genetic imaging studies. Eighty three consecutive 72 included study. All patients underwent clinical measurements height, body weight, mass index (BMI), waist hip circumference. Biochemical...
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and death.The most common COPD smoking.There evidence suggesting that genetic factors influence susceptibility variants in several candidate genes have been significantly associated with COPD.In this study, we aimed to investigate the possible association TNF-α -308, SPB+1580, IL-13 -1055 gene polymorphisms latent adenovirus C infection an Egyptian population.Material methods: Our study included 115...
End stage renal disease (ESRD) is a common cause of morbidity and mortality among children. Interleukin 4 cytokine that might influence the progression chronic kidney (CKD) to end disease. There are variable number tandem repeats (VNTRs) in IL4 gene could play major roles genetic predisposition some diseases. Aim study: The purpose this study detect association allelic variant intron 3 VNTR-IL4 with if these variants be considered as risk markers for was conducted on fifty-five children CKD...
Diabetes mellitus is considered a major public health problem worldwide. Susceptibility to diabetes influenced by both genetic and environmental determinants. The aim of the present study was test for 16 independent single nucleotide polymorphisms (SNPs) in established Type 2 (T2D) obesity susceptibility loci GWAS sample Egyptian patients find out if there shared background underlying disease entities. Genotyping performed using OpenArray® protocol on QuantStudio™ 12K Flex Real-Time PCR...
The aim of this study was to assess the association between four vitamin D receptor (VDR) single nucleotide polymorphisms BsmI (rs1544410), ApaI (rs7975232), FokI (rs2228570) and TaqI (rs731236) susceptibility chronic kidney disease (CKD) in Egyptian children evaluate their with mineral status these patients.The current included 305 patients CKD 100 apparently healthy children. We measured serum (VD), para-thyroid hormone (PTH) level fibroblast growth factor 23 (FGF-23) levels by ELISA...
Objective: Nephrolithiasis results from metabolic and anatomic abnormalities together with genetic factors.Claudin 14 (CLDN14) is a protein that regulates the passage of small solutes through kidneys.Alkaline phosphatase (ALPL) hydrolyzes pyrophosphate to free phosphate, proposing its enabling role in nephrolithiasis development.Solute carrier family 13 member 2 (SLC13A2) encodes Na+-Pi cotransporter 2a, which responsible for renal absorption phosphate.We aimed detect association between...
Extensive allele diversity is observed in HLA associations with response to HCV combined therapy (pegylated interferon + ribavitin) different global ethnic populations. The aim of the study assess frequency and association certain HLA-class I alleles Egyptian persons persistent others sustained viral (SVR). was a retrospective cohort that included 246 patients who received therapy; 106 cases responded treatment (SVR) 140 individuals did not respond (persistent infection). Both groups are...
AIM: We examined the role that immunoglobulin GM 23 and KM allotypes—genetic markers of γ κ chains, respectively—play in response to treatment hepatitis C virus (HCV) infection Egyptian patients.MATERIAL AND METHODS: A total 120 persons who had responded HCV 125 with persistent were genotyped for presence GM23 determinants. HLA –C genotyping was also done.RESULTS: Association 23+ KM3 significantly associated non (P < 0.0001). Individuals lacked this genotype (but positive KM1,2 3)...
BACKGROUND: Fetuin-A and ghrelin have been implicated in cardiovascular diseases mortality among end stage renal disease patients. The exact mechanisms not fully elucidated. There is robust data supporting an association between various conditions, some common processes such as inflammation, oxidative stress, endoplasmic reticulum stress implicated.AIM: This study was conducted to assay serum fetuin-A chronic failure pediatric patients changes their level that may occur after a single...
The signalling pathway Fas and FasL system plays a fundamental role in the regulation of apoptotic cell death any disturbance this has been shown to promote immune escape tumorigenesis. Many types cancers show reduced expression FAS elevated expression. Fas21377G/A, FasL2844T/C polymorphisms might be associated with increased risk lung cancer. interplay between genetic could participate cancer development. This study aimed examine contribution Fas21377AA FasL2844CC genotypes developing A...