Omentin-1 a new anti-inflammatory adipokine has been identified as major visceral (omental) secretory which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels type 2 diabetic obese females assess its relation with glycemic control, metabolic parameters. included 60 30 healthy female subjects formed the control group. They subjected full clinical examination, weight, height, waist hip...

Background Infant mortality due to congenital cardiac defects is quite high. Since cardiovascular collapse and arrest are possible outcomes of heart diseases (CHDs) that go undetected, accurate auscultation the physical examination newborns, together with prompt echocardiography (echo), crucial in early detection disorders initiation therapy. Aim Objectives To determine sensitivity specificity clinical detecting CHD neonates. Subjects Methods This research was a prospective cross-sectional...

ABSTRACT Introduction Diabetes mellitus (DM) is a serious health condition affecting people worldwide with high prevalence rate. DM classified according to its aetiology into type 1 diabetes (T1DM) and 2 (T2DM); several risk factors contribute the development of T2DM, such as age, genetic predisposition obesity. Metformin proven drug choice, it used first‐line treatment for patients T2DM improve their glycaemic levels. Vitamin B12 an important water‐soluble vitamin, deficiency can lead...

Abstract Background Laser acupuncture is one of the complementary modalities used for treating osteoarthritis. The study was performed to evaluate effectiveness laser in treatment grade 2 knee Patients and methods Forty patients having bilateral osteoarthritis were divided into two groups (20 each group). first group subjected 12 sessions at following acupoints (St 35, St36, Sp9, Sp10 Gb 34). During session, 90 mw directed acupoint 1 min giving energy 5.4 joules. Energy 21.6 joules ashi...

Osteopontin (OPN) is a secreted glycoprotein and frequently associated with various tumors.We sought to investigate the clinical usefulness of level plasma OPN, compared α-fetoprotein (AFP), as biomarker for hepatocellular carcinoma (HCC) evaluate its diagnostic value in nonalcoholic fatty liver disease (NAFLD) relationship laboratory features HCC NAFLD.The study was performed on 120 subjects classified into 5 groups: Group I included 25 chronic non-cirrhotic hepatitis C virus (HCV)-infected...

We studied JAZF1, ABCC8, KCNJ11and Notch2 gene expression and vitamin D receptor (VDR) polymorphisms (Fok1 Bsm1) in patients with type 2 diabetes mellitus (T2DM) tried to find out their association microvascular complications these patients.The study was conducted on 180 (93 complicated 87 noncomplicated) 150 healthy subjects. Reverse-transcriptase polymerase chain reaction (RT-PCR) used assess real-time PCR detect VDR genotypes. Serum assessed using Elisa technique.After adjustment for age,...

The Pediatric Acute Lung Injury Consensus Conference (PALICC) published pediatric-specific guidelines for the definition, management, and research in pediatric acute respiratory distress syndrome (PARDS). viral bronchiolitis (AVB) remains one of leading causes admission to PICU. Respiratory syncytial virus (RSV) is most common cause AVB. We aimed evaluate incidence PARDS AVB identify risk RSV as a trigger pathogen PARDS. This study retrospective single-center observational cohort including...

Thalassemia is a congenital hemolytic disease caused by defective globin synthesis treated blood transfusion. Transfusion-transmitted infections still make great challenge in the management of patients with thalassemia major. The most important worldwide transfusion-transmitted are hepatitis B virus (HBV), C (HCV) and HIV. objective this study to update prevalence three major HCV, HBV HIV among thalassemic followed up Hematology Department, Children Hospital, Cairo University. included 174...

Vascular endothelial growth factor (VEGF), platelet derived cell factor/thymidine phosphorylase (PD-ECGF/TP) and leptin are known as potent angiogenic factors The objective of the study was to evaluate these VEGF, PD-ECGF/TP in children with congenital heart disease (CHD) that lead angiogenesis such cases. Sixty CHD were studied divided into two groups (n = 30); cyanotic-CHD (C-CHD) acyanotic-CHD (A-CHD). Twenty five healthy included controls. Significantly higher serum levels activity...

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Multiple genetic and epigenetic changes are involved in molecular pathogenesis HCC. Heat shock proteins have essential roles protecting cells from potentially lethal effects stress. Among them, HSP70 often overexpressed various cancers been suggested to contribute tumourigenesis. p53 mutations codon 249 also identified HCC.Fifty patients with liver disease were enrolled this study compared 10 healthy volunteers....

Background: Several cardiovascular risk factors have been recognized in patients with diabetes and vitamin D deficiency is emerging as a new risk. The aim of this study was to determine the effect on incidence premature atherosclerosis type 2 diabetes. Methods: A total 78 were subjected history taking, physical examination, fasting glucose level, homeostasis model assessment insulin resistance, lipid profile, 25(OH) measurement, carotid Doppler. Results: Patients normal intima-media...

BACKGROUND: Cardiovascular disease (CVD) is a common but chronic condition that can cause death, and seen as substantial source of disability health costs. A balance between prevention intervention, the case with other infectious diseases, best way to stem increasing burden CVD.
 AIM: This study assesses prevalence diabetes mellitus, hypertension, in sample from University Tabuk.
 METHODS: cross-sectional was done 2018, 120 employees students at Tabuk (in City, Saudi Arabia), for...

Hepatitis C virus is one of the most common etiologic agents chronic liver diseases, including cirrhosis and hepatocellular carcinoma in which there continuous inflammation regeneration hepatocytes. Cytokeratin-18 (CK18) has been suggested to play an important role tumorigenesis epithelial cancers.Estimation CK18 serum levels patients with viral hepatitis (CHCV) (HCC) find relationship between their levels, severity disease development HCC.We measured 60 Egyptian (30 CHCV & 30 HCC) healthy...

Secondary carnitine deficiency may develop in chronic renal failure (CRF) patients undergoing long-term hemodialysis (HD), with a resulting higher incidence of cardiovascular diseases, dyslipidemia and oxidative stress. We studied the efficacy 12 months L-carnitine supplementation on amelioration dyslipidemia, stress cardiac dysfunction 24 CRF children HD compared age- sex-matched controls.Plasma samples were analyzed spectrophotometerically before after dialysis sessions 2-month oral (50...

Myeloperoxidase (MPO) is an important enzyme that found in neutrophils and involved reactive oxygen species (ROS) production.The aim of the current study was to clarify potential role MPO oxidative stress liver fibrosis associated with hepatitis C virus (HCV) infection.This conducted on 90 subjects, 10 normal controls 80 patients having HCV infection classified into chronic without cirrhosis (CHC) (50 cases) CHC (LC) (30 cases).Myeloperoxidase assessed plasma by ELISA technique tissue...

Abstract Introduction Obesity is commonly associated with insulin resistance and hyperinsulinemia the most important risk factor for type 2 diabetes. Visfatin an adipokine that exerts insulin-mimetic effects stimulate muscle adipocyte glucose transport inhibit hepatocyte production. Purpose The aim of this study was to assess levels visfatin its relationship obesity in diabetes mellitus. Patients methods This included 40 patients as patient group: 20 them were obese (BMI ≥ 30) not < 25)....

Background: Hypomagnesaemia may have negative impact on glucose homeostasis and insulin sensitivity. This study was done to compare serum Mg levels in type 2 diabetic patients with non healthy control subjects assess the correlation between glycemic Egyptian patients.Methods: 60 attending outpatient clinic of diabetes at Kasr Al Aini hospital faculty medicine Cairo University 30 age matched were enrolled. Fasting blood sugar, fasting insulin, lipids, Hb A1C measured. Weight, height pressure...

The prognosis of hepatocellular carcinoma (HCC) is unfavorable and needs serum markers that could detect it early to start therapy at a potentially curable phase.The aim this study was determine the value soluble tumor necrosis factor (TNF) receptor-IIα (sTNFR-IIα) in diagnosis HCC patients with chronic hepatitis C virus (HCV) infection.The performed on 110 subjects who were classified into five groups. Group I included 20 noncirrhotic HCV infection persistently normal transaminases for ≥6...

Hepatitis C viral (HCV) infection is a major risk factor for liver cirrhosis, failure, and hepatocellular carcinoma (HCC). A number of laboratory-based methods has been developed the noninvasive diagnostic evaluation HCC. Endoglin (CD105) homodimeric membrane glycoprotein expressed on endothelial cells that can bind to transforming growth factor-b1 factor-b3. The aim this study was evaluate value endoglin a-fetoprotein (AFP) in patients with chronic HCV without total 50 were chosen divided...

Bone disease in β-thalassemia major (βTM) remains poorly understood. Receptor activator of nuclear factor-κβ ligand (RANKL) regulates osteoclast formation and function. RANKL activity is balanced by interaction with its receptor (RANK) binding to osteoprotegerin (OPG). L-Carnitine (LC) enhances osteoblastic furnishing fuel. This study hypothesized that abnormal bone metabolism βTM involves imbalanced RANKL/OPG LC/free fatty acids (FFAs) metabolism. Sixty-nine transfusion-dependent patients...

Apelin is an adipokine that may have advantageous role in the prediction of early diabetic nephropathy. A few studies on apelin diabetes been performed and this research was to establish connection between apelinergic system nephropathy.The included 60 patients with type 2 mellitus (T2DM) who were equally divided into Group-I (diabetic nephropathy) Group-II (non-diabetic nephropathy), 30 healthy subjects control group (Group-III). Body mass index (BMI) waist circumference calculated. FBG,...

Arterial stiffness was reported with corona virus disease 2019 (COVID-19). We studied atherosclerosis in COVID-19 directly through duplex ultrasound measurements and their relation to co-morbidities, clinical laboratory severity markers, serum interleukin (IL) 6 17. Serum IL 17, average carotid intima-media thickness (cIMT), diameter peak systolic velocities (PSV) of tibial, ulnar, radial arteries, ankle brachial index (ABI) were measured 44 patients healthy controls. IL6, IL17, PSV, cIMT...