A5031510026- Retinoids in leukemia and cellular processes
- Pancreatic function and diabetes
- Oral Health Pathology and Treatment
- Neuroblastoma Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Diet, Metabolism, and Disease
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Diet and metabolism studies
- Cytomegalovirus and herpesvirus research
- Oral microbiology and periodontitis research
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Dialysis and Renal Disease Management
- Oral health in cancer treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory mediators and NSAID effects
- Berberine and alkaloids research
- Psoriasis: Treatment and Pathogenesis
Jouf University
2015-2024
Assiut University
2010-2024
National Water Research Center
2017
University of Michigan
2011-2016
National Institutes of Health
2016
National Institute of Dental and Craniofacial Research
2016
Creighton University
1999-2005
University of Nebraska Medical Center
2000-2005
Individual Differences
2000
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial with complex pathophysiology. The clinical features of NAFLD include obesity, insulin resistance (IR) and dyslipidemia. Consumption diet high in saturated fats sucrose an important factor the increasing occurrence these metabolic disorders, primarily IR. We sought to assess role high-fat, high-sucrose (HFS) promotion evaluate effects quercetin (Q), berberine (BB) o-coumaric acid (CA) on modulation disorders. Fifty male rats were...
The <i>MUC4</i> mucin is considered as the homologue of rat sialomucin complex (SMC, Muc4) due to its similar structural organization. Like SMC, MUC4 may also exist two subunits: a type unit known MUC4α and growth factor-like transmembrane subunit, MUC4β. expression in normal human pancreas not detectable, but it highly expressed pancreatic tumor cells. In present study, we investigated regulation cells CD18/HPAF, exhibiting high level transcripts protein. When these were adapted grow...
This study aimed to investigate the oxidative stress, hypoxia biomarkers, and circulating microparticles (MPs) in β thalassemia major. The included 56 children with 46 healthy controls. Hypoxia stress total plasma fragmented DNA (fDNA) were detected by standard methods. MPs assessed flow cytometry. fDNA, higher antioxidant capacity (TAC) was lower patients than In splenectomized those who had complications, vascular endothelial growth factor (VEGF), malondialdehyde, endothelial, platelet,...
Background: Our previous investigations showed that retinoids, at specific concentrations, can inhibit cell proliferation .In this investigation, we hypothesize high concentrations of retinoids induce phenotypic changes (differentiation) and late apoptosis in pancreatic cancer cells vitro. Materials methods: To test our hypothesis, retinoid-induced differentiation was assessed: 1) phenotypically by light electron microscopy 2) biochemically measuring carbonic anhydrase, aerobic metabolic...
Being best-studied superficial bladder cancer (SBC) chemopreventives, retinoids' negative studies and toxicity were stumbling. With proper understanding of retinoid metabolism, we aimed at investigating combined ketoconazole (a strong inhibitor retinoic acid-catabolizing cytochrome P450s) all-trans acid (Keto-atRA) SBC treatment. VEGF TGFalpha levels are end-point pathogenetic biomarkers involved in early SBC.Keto-atRA treatment significantly improved survival time decreased recurrence rate...
Tissue injury due to hypoxia and/or free radicals is common in a variety of disease processes. This cross-sectional study aimed investigate effect chronic kidney diseases (CKD) and hemodialysis (HD) on oxidative stress biomarkers.Forty pediatric patients with CKD HD 20 healthy children were recruited. Plasma induced factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) measured by specific ELISA kits while, total antioxidant capacity (TAC), peroxide (TPX), pyruvate lactate...
Background Podoconiosis (endemic nonfilarial elephantiasis) occurs in susceptible individuals who go barefoot regions of irritant volcanic soil. Silicate particles absorbed via the skin are thought to induce an inflammatory process and a consequent endolymphangitis lower leg lymphatics. Objectives To establish which oxidative stress biomarkers play part process, test whether transforming growth factor (TGF)-β1 also has pathogenetic role. Patients methods We enrolled 50 patients with early...
Background: The anticancer ability of natural retinoids on pancreatic adenocarcinoma, an aggressive tumor, is still controversial. This investigation tested the hypothesis that all-trans retinoic acid can inhibit proliferation and induce apoptosis in cancer cell lines. Materials methods: Using our previously optimized conditions, effect (atRA, 0.001 - 10 µM) was ten human adenocarcinoma lines with various degrees differentiation. Proliferation monitored by number, [3H]-thymidine...
Vitamin D (VitD) deficiency during pregnancy has been associated with adverse neonatal outcomes and increased risk of late complications.We planned to correlate serum VitD biomarkers; 25-hydroxyvitamin (25-OH-VitD) 1,25-dihydroxyvitamin (1,25-diOH-VitD) levels; their ratio the frequency feto-maternal complications.A prospective cross-sectional case-control study was conducted at Aljouf Maternity Children Hospital, Sakaka, Saudi Arabia, period September 1, 2017 30, 2019.322 pregnant women...
Tumor transplants into nude mice (NM) may reveal abnormal biological behavior compared with the original tumor. Despite this, human tumor xenografts in NM have been widely used to study biology of tumors and establish diagnostic therapeutic modalities. Clearly, precise differences a given cannot be assessed. We growth kinetics, differentiation pattern karyotype an anaplastic Syrian hamster pancreatic cancer cell line allogenic hamsters. As tumor, hamsters grew fast, were expressed markers...
ABSTRACT All‐trans Retinoic acid (atRA) is instructive for the development of endocrine pancreas and an integral component β‐cell induction protocols. We showed that atRA induces glucose‐responsive transdifferentiation pleomorphic pancreatic ductal adenocarcinoma cells in vitro . This study aimed to detect role improving histological changes diabetic rats. Forty young male Wistar rats were used divided into three groups. Group I: normal vehicle control (N = 5). II: streptozotocin‐induced 20)...
Hepatitis C virus (HCV) is the main cause of chronic liver disease, with calamitous complications. Its highest rate recorded in Egypt. This study investigated whether oxidative stress, immunological chaos and cellular hypoxia are implicated pathophysiology disease.This cross-sectional aimed to evaluate changes blood hypoxia/angiogenesis biomarkers hospital-diagnosed treatment-naïve HCV-infected Upper Egyptian disease patients vs. healthy controls (n = 40). The consecutively included...