A5066401293- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Genetic Associations and Epidemiology
- Fungal Infections and Studies
- Pneumonia and Respiratory Infections
- Genomics and Phylogenetic Studies
- Machine Learning in Bioinformatics
- Bacterial Infections and Vaccines
- Mycobacterium research and diagnosis
- Sports and Physical Education Research
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Diaphragmatic Hernia Studies
- Dietary Effects on Health
- Educational Research and Methods
- Electrolyte and hormonal disorders
- Food Security and Socioeconomic Dynamics
- Data Mining and Machine Learning Applications
- Tryptophan and brain disorders
- Cytokine Signaling Pathways and Interactions
- Antifungal resistance and susceptibility
- Studies on Chitinases and Chitosanases
- Multimedia Learning Systems
- Mathematics Education and Pedagogy
- STEM Education
Padjadjaran University
2019-2025
University Medical Center
2023
Radboud University Medical Center
2019-2023
Radboud University Nijmegen
2019-2023
Radboud Institute for Molecular Life Sciences
2019-2023
University of Indonesia
2021
Universitas PGRI Semarang
2020
Universitas Muhammadiyah Tapanuli Selatan
2020
Background: Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand characteristic immunopathology of tuberculosis. We performed targeted analyses in a large cohort patients with tuberculous meningitis (TBM), most severe manifestation tuberculosis, focusing on tryptophan metabolism. Methods: studied 1069 Indonesian Vietnamese adults TBM (26.6% HIV-positive), 54 non-infectious controls, 50 bacterial meningitis, 60...
Existing genotype imputation reference panels are mainly derived from European populations, limiting their accuracy in non-European populations. To improve for Indonesians, the world's fourth most populous country, we combined Whole Genome Sequencing (WGS) data 227 West Javanese individuals with East Asian 1,000 Genomes Project. This created three panels: EAS 1KGP3 (EASp), Indonesian (INDp), and a panel (EASp + INDp). We also used ten West-Javanese samples WGS SNP-typing benchmarking....
Abstract Immunopathology contributes to high mortality in tuberculous meningitis (TBM) but little is known about the blood and cerebrospinal fluid (CSF) immune response. We prospectively characterised response of 160 TBM suspects an Indonesian cohort, including 67 HIV-negative probable or definite cases. patients presented with severe disease 38% died 6 months. Blood from analysed by flow cytometry showed lower αβT γδT cells, NK cells MAIT compared 26 pulmonary tuberculosis (2.4-4-fold, all...
Abstract Background The purpose of this study was to assess if single nucleotide polymorphisms (SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium tuberculosis outcomes. Methods Independent SNPs (genotyped by Illumina HumanOmniExpress array) were assessed for associations tumor necrosis factor (TNF) concentrations (measured immunoassay) cerebral spinal fluid (CSF) from tuberculous meningitis (TBM) patients. CSF TNF carried forward analyses pulmonary meningeal...
Little is known about the etiology, clinical presentation, management, and outcome of central nervous system (CNS) infections in Indonesia, a country with high burden infectious diseases rising prevalence HIV.
Abstract Studies in IL-32 transgenic mice and vitro suggest that may have protective effects against Mycobacterium tuberculosis, but so far there are barely any studies humans. We studied the role of its splice variants tuberculosis (TB) vivo vitro. Blood transcriptional analysis showed lower total mRNA levels pulmonary TB patients compared to with latent infection healthy controls. Also, among Indonesian household contacts who were heavily exposed an infectious patient, higher those...
Hyponatremia is common in tuberculous meningitis (TBM), but its impact on disease severity and outcomes unclear. In a cohort of 864 adult patients with TBM Indonesia, we assessed the prevalence prognostic significance hyponatremia, classified as moderate (120-130 mEq/L) or severe (<120 mEq/L). Patients received standard antituberculous therapy corticosteroids were followed for 1-year mortality. occured 86.8% patients, 26% severe. Severe hyponatremia associated male, younger age, lower...
Summary Existing genotype imputation reference panels are mainly derived from European populations, limiting their accuracy in non-European populations. To improve for Indonesians, the world’s fourth most populous country, we combined Whole Genome Sequencing (WGS) data 227 West Javanese individuals with East Asian 1000 Genomes Project. This created three panels: EAS 1KGP3 (EASp), Indonesian (INDp), and a panel (EASp+INDp). We also used ten West-Javanese samples WGS SNP-typing benchmarking....
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides and different clinical forms disease are associated with host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants mononuclear-cells-derived cytokines induced P. brasiliensis on 158 individuals. We identified rs11053595 SNP, which present in CLEC7A gene (encodes Dectin-1 receptor) rs62290169 SNP located PROM1 CD133) production IL-1β IL-22,...
Abstract Background Cellular metabolism is critical for the host immune function against pathogens, and metabolomic analysis may help understand characteristic immunopathology of tuberculosis. We performed targeted analyses in a large cohort patients with tuberculous meningitis (TBM), most severe manifestation tuberculosis, focusing on tryptophan metabolism. Methods studied 1069 Indonesian Vietnamese adults TBM (26.6% HIV-positive), 54 non-infectious controls, 50 bacterial meningitis, 60...
ABSTRACT Rationale Lung mucins are an understudied component of the mucosal immune response and may influence tuberculosis pathogenesis outcomes. Objectives To assess if variants in lung MUC5B MUC5AC associated with Mycobacterium responses, susceptibility, Methods We characterized four haplotype tagging single nucleotide polymorphisms (SNPs) for association log 2 TNF concentrations cerebral spinal fluid (CSF) from TBM patients. SNPs CSF were carried forward analyses pulmonary meningeal TB...