A5107519526- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Salmonella and Campylobacter epidemiology
- Animal Virus Infections Studies
- Escherichia coli research studies
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Neonatal Health and Biochemistry
- Bacterial Infections and Vaccines
- Pharmacological Effects and Toxicity Studies
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- COVID-19 epidemiological studies
- Infective Endocarditis Diagnosis and Management
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Influenza Virus Research Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemoglobinopathies and Related Disorders
- Amoebic Infections and Treatments
- Infant Nutrition and Health
- Tropical and Extratropical Cyclones Research
- Virus-based gene therapy research
Oxford University Clinical Research Unit Indonesia
2012-2024
University of Indonesia
2022-2024
Eijkman Institute for Molecular Biology
2010-2022
Research Network (United States)
2010
Naval Medical Research Command
1993-2001
Ministry of Health
1997
Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) Plasmodium vivax malaria. In areas chloroquine resistance, artemisinin-based combination therapies are used to treat This study aimed evaluate tafenoquine plus therapy dihydroartemisinin-piperaquine P malaria.In this double-blind, double-dummy, parallel group study, glucose-6-phosphate dehydrogenase-normal Indonesian soldiers microscopically confirmed malaria were randomly assigned by...
<h3>Importance</h3> Latent hepatic<i>Plasmodium vivax</i>hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. <h3>Objective</h3> To examine the association of impaired<i>CYP2D6</i>genotypes CYP2D6 metabolic phenotypes with failure directly observed high-dose treatment for<i>P vivax</i>malaria relapse. <h3>Design, Setting,...
We conducted a prospective, inpatient fever study in malaria-endemic Papua, Indonesia to determine non-malaria etiologies. Investigations included malaria blood films, culture, paired serologic samples analysis for dengue, Japanese encephalitis, leptospirosis, scrub typhus, murine and spotted group rickettsia. During 1997-2000, 226 patients (127 males 99 females) 1-80 years of age (median = 25 years) were enrolled. Positive cultures (n 34, 15%) obtained Salmonella Typhi 13), Escherichia coli...
Safety and efficacy of primaquine against repeated attacks Plasmodium vivax depends upon co-administered blood schizontocidal therapy in radical cure. We assessed (PQ) as hypnozoitocide when administered with dihydroartemisinin-piperaquine (Eurartesim®, DHA-PP) or artesunate-pyronaridine (Pyramax®, AS-PYR) to affirm its good tolerability efficacy. A third arm, artesunate followed by primaquine, was not intended for practice, but addressed a hypothesis concerning without co-administration...
Background Patients infected by Plasmodium vivax or ovale suffer repeated clinical attacks without primaquine therapy against latent stages in liver. Primaquine causes seriously threatening acute hemolytic anemia patients having inherited glucose-6-phosphate dehydrogenase (G6PD) deficiency. Access to safe hinges upon the ability confirm G6PD normal status. CareStart G6PD, a qualitative rapid diagnostic test (G6PD RDT) intended for use at point-of-care impoverished rural settings where most...
Limited data exist from southeast Asia on the impact of SARS-CoV-2 variants and inactivated vaccines disease severity death among patients hospitalised with COVID-19.
The prevalence of bacteria, parasite and viral pathogens in 3875 patients with diarrhea community hospital settings from March 1997 through August 1999 Jakarta, Indonesia was determined using routine bacteriology molecular assay techniques.Bacterial isolated were, decreasing frequency, Vibrio cholerae O1, Shigella flexneri, Salmonella spp.and Campylobacter jejuni, while S. V. C. jejuni were the patients.V. O1 more frequently (P 6 0.005) than patients.Overall, bacterial 538 (14%) enrolled...
Norwalk-like viruses (NLVs), rotavirus and adenovirus are reportedly responsible from 4 to 42% of non-bacterial acute sporadic gastroenteritis. The incidence NLVs, infections in Indonesia is unclear. A total 402 symptomatic cases Indonesian patients with gastroenteritis 102 asymptomatic controls that tested negative for bacteria parasites were screened the presence using reverse transcriptase-polymerase chain reaction (RT-PCR), Rotaclone kits Adenoclone kits. Specific prototype probes used...
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Tens of millions patients diagnosed with vivax malaria cannot safely receive primaquine therapy against repeated attacks caused by activation dormant liver stages called hypnozoites. Most these lack access to screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency, a highly prevalent disorder causing serious acute hemolytic anemia therapy. We optimized CuCl inhibition G6PD in normal red blood cells (RBCs) assess diagnostic technologies suited point care the impoverished rural...
Abstract Norwalk virus (NV) and Norwalk‐like viruses (NLVs) are common etiologic agents of viral gastroenteritis. Viral gastroenteritis is a disease that highly transmissible, spreading rapidly through families, institutions, communities. Because methods for in vitro cultivation not available, information regarding this syndrome has come largely from studies human volunteers. Sequential passaging an NLV immunoincompetent newborn pigtail macaque ( Macaca nemestrina ) may allow the adaptation...
Little is known about the etiology, clinical presentation, management, and outcome of central nervous system (CNS) infections in Indonesia, a country with high burden infectious diseases rising prevalence HIV.
From June 1998 through November 1999, Shigella spp. were isolated in 5% of samples from 3,848 children and adults with severe diarrheal illness hospitals throughout Indonesia. S. dysenteriae has reemerged Bali, Kalimantan, Batam was detected Jakarta after a hiatus 15 years.
ABSTRACT Antibiotic susceptibilities were determined for 122 Neisseria gonorrheae isolates obtained from 400 sex workers in Jakarta, Indonesia, and to ciprofloxacin, cefuroxime, cefoxitin, cefotaxime, ceftriaxone, chloramphenicol, spectinomycin found. All resistant tetracycline. A number of the demonstrated decreased erythromycin (MIC ≥ 1.0 μg/ml), thiamphenicol kanamycin 16.0 penicillin 2.0 gentamicin norfloxacin = 0.5 μg/ml). These data showed that certain antibiotics previously used...
Cholera-specific surveillance in Indonesia was initiated to identify the introduction of newly recognized Vibrio cholerae non-O1, O139 serotype. Findings from seven years (1993-1999) efforts also yielded regional profiles importance cholera both epidemic and sporadic diarrheal disease occurrence throughout archipelago. A two-fold strategy pursued involving 1) outbreak investigations, 2) hospital-based case recognition. Rectal swabs were transported Jakarta for culture isolates characterized...
Abstract Norwalk Virus and Norwalk‐like viruses (NLVs) are reportedly responsible for 2.5–4.0% of nonbacterial acute gastroenteritis (NBAG) worldwide. To help clarify the impact NLVs on NBAG in Indonesia, stool specimens from 102 patients, 74 with 28 BAG, were screened presence NLVs, using a reverse transcription‐polymerase chain reaction (RT‐PCR) assay. The subtyped prototype‐specific oligonucleotide probes sequenced compared published NLV sequences. Of examined, 31 (30%) found to be...
Methicillin-resistant Staphylococcus aureus (MRSA) colonization is associated with serious surgical site infection in high-risk patients. High prevalence of MRSA was reported many settings, nonetheless local data required. The purpose this study to identify the and risk factor nasal carriage adult patients National Referral Hospital Indonesia before underwent elective procedure.From 384 patients, 16.9% them had undergone orthopaedic surgery, 51.3% received antibiotics within previous 3-month...
Infection caused by enterotoxigenic Escherichia coli (ETEC) poses a serious health problem among children and adults in developing countries. Colonization of the small intestinal mucosa ETEC strains is mediated antigenically specific fimbriae, also known as colonization factor antigens (CFA). The significance this study arises from reports that active passive immunization with harboring CFAs has previously been shown to induce protective immunity against diarrhea animal models. aim was...
Norwalk virus has been implicated in shipboard diarrheal disease outbreaks throughout Asia. A large outbreak of suspected was investigated on a U.S. Naval aircraft carrier following the clinical recognition 450 cases gastroenteritis over 2-week period (September 14-28, 1997) during coastal exercises. random sampling 44 from personnel who sought medical attention compared with 19 controls. Junior enlisted sailors and marines comprised 97% all cases. There no evidence geographic clustering...
Background Plasmodium vivax occurs as a latent infection of liver and patent red blood cells. Radical cure requires both schizontocidal hypnozoitocidal chemotherapies. The therapies available are primaquine tafenoquine, 8-aminoquinoline drugs that can provoke threatening acute hemolytic anemia in patients having an X-linked G6PD-deficiency. Heterozygous females may screen G6PD-normal prior to radical go on experience crisis. Methods & findings This study examined G6PD phenotypes 1928...
A direct-plating method on thiosulfate citrate bile salts sucrose agar (DIR-TCBS) in conjunction with enrichment alkaline peptone water (APW) incubated for both 6 h and 24 followed by subculture onto TCBS (APW6h-TCBS APW24h-TCBS, respectively) was performed 16,034 rectal swab samples isolating Vibrio cholerae. total of 2,932 (18.3%) were positive V. cholerae O1 biotype El Tor, the Ogawa serotype constituting 99.2% isolates. There no significant differences isolation rates between three...
Typhoid fever diagnosis is challenging for clinicians in areas with limited laboratory facilities. Scoring methods based on signs and symptoms are useful screening probable cases of typhoid fever. The Nelwan Score variables derived from the clinical patients suspected typhoid. We validated compared to tests as gold standard.This cross-sectional study was conducted between July 2017 January 2018 five hospitals two primary health care centers Jakarta Tangerang, Indonesia. Patients 3-14 days...