A5089402633- Phosphodiesterase function and regulation
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Neuroscience of respiration and sleep
- Sexual function and dysfunction studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Pharmacological Effects and Toxicity Studies
Atatürk University
2022-2025
Objectives: Increasing the effectiveness and reliability of Akt inhibition in lung cancer treatment may pave way for a more favorable use this method future. Therefore, we aimed to evaluate possible role RhoB regulation NSCLC. Material Methods: The study was conducted using NSCLC cell line A549. Small interfering RNA (siRNA)-mediated knockdown performed combined with perifosine (Akt inhibitor) treatment. Cell proliferation detected by xCELLigence® RTCA. RhoB, pAkt, Bcl2l11 expressions were...
Sepsis is a syndrome that includes physiological, pathological, and biochemical abnormalities resulting from the host immune response to infection. Despite improved treatment modalities in recent years, incidence mortality of sepsis are still increasing. immunopathology increasingly attracting attention researchers. The successes experienced with immunotherapeutics cancer coronavirus disease 2019, which diseases similar pathophysiological features common defects sepsis, have given rise hope...