A5062864737- Immune Response and Inflammation
- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Neurological Disorders and Treatments
- COVID-19 Clinical Research Studies
- Neurological Complications and Syndromes
- Traditional Chinese Medicine Analysis
- Nosocomial Infections in ICU
- Pulmonary Hypertension Research and Treatments
- Nanocluster Synthesis and Applications
- Inhalation and Respiratory Drug Delivery
- Epilepsy research and treatment
- Paraoxonase enzyme and polymorphisms
- Phosphodiesterase function and regulation
- Medicinal Plants and Neuroprotection
- Medical and Biological Ozone Research
- Intensive Care Unit Cognitive Disorders
- Apelin-related biomedical research
- Carbon and Quantum Dots Applications
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Receptor Mechanisms and Effects
- MRI in cancer diagnosis
- Hydrogen's biological and therapeutic effects
Sakarya University
2023-2025
Atatürk University
2021-2024
Kafkas University
2023
Abstract Background Sepsis is a life-threatening organ dysfunction resulting from dysregulated host response to infection. Due the high mortality rates and treatment costs associated with sepsis, research focusing on innovative strategies replace one dimensional approaches. Recent studies are being conducted use of immunotherapeutics in sepsis impact timing. This study aimed elucidate significance timing immunotherapy Tocilizumab (TCZ) implications differences Methods LPS-induced model was...
This study investigated the synergistic protective effects of melatonin (MEL) and ascorbic acid (vitamin C, ASA) in treating sepsis-induced lung injury rats. Rats were divided into five groups: control, cecal ligation puncture (CLP), CLP + MEL, ASA MEL ASA. The (10 mg/kg), (100 mg/kg) their combination on oxidative stress, inflammation histopathology evaluated septic rats' tissues. Sepsis-induced stress evident through increased levels malondialdehyde (MDA), myeloperoxidase (MPO), total...
Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple failure. Although much research has been conducted to illuminate sepsis's complex pathophysiology, sepsis treatment protocols are limited, remains important of mortality andmorbidity intensive care units.Various studies have shown idebenone (IDE) possesses strong antioxidant properties, which inhibit lipid peroxidation protect cells from oxidative damage....
In the last two decades, fluorescent carbon quantum dots (CQDs) have attracted intense interest as a new nanomaterial with unique properties. This material offers significant advantages compared conventional dyes and inorganic QD systems, is used extensively in many different fields, especially bioimaging sensor applications. Despite all positive values they offer, production of CQD systems excitation wavelength-dependent nature high yield (QY) still scientific challenge. this study, we...
This study aims to investigate the protective effect of roflumilast, a phosphodiesterase (PDE)-4 enzyme inhibitor, and demonstrate its possible role in development prevention cerebral ischemia/reperfusion injury (CI/RI) after stroke induced by carotid artery ligation juvenile rats. The rats were randomly divided into five groups: healthy group without any treatment, administered with 1 mg/kg CI not 0.5 roflumilast. In groups, reperfusion was achieved 2h ischemia induction; roflumilast this...
The aim of study was to investigate the effect avanafil, a second-generation phosphodiesterase-5 (PDE5) inhibitor, on cerebral ischemia reperfusion (CI/R) model.
A sepsis model was created, induced by cecal ligation and puncture (CLP), in juvenile rat groups. Milrinone (MIL), which is known to have a modulatory effect on pro-inflammatory cytokines, administered the designated groups early period before severe developed. The study aimed at investigating possible protective effects of milrinone lung kidney tissues rats late phase sepsis.The pups were divided into seven with six animals each group: (1) healthy who received no drug; (2) CLP-S12...
Sepsis is a syndrome that includes physiological, pathological, and biochemical abnormalities resulting from the host immune response to infection. Despite improved treatment modalities in recent years, incidence mortality of sepsis are still increasing. immunopathology increasingly attracting attention researchers. The successes experienced with immunotherapeutics cancer coronavirus disease 2019, which diseases similar pathophysiological features common defects sepsis, have given rise hope...
The study aimed to evaluate serum interleukin-28 levels in COVID-19 patients and correlate the results with disease severity.This included 90 who presented outpatient clinics, hospital wards, intensive care units. Serum interleukin-28, C-reactive protein, lactate dehydrogenase, fibrinogen, d-dimer, ferritin were measured. Patients divided into 3 groups based on clinical severity mild, moderate, severe (each group consisted of 30 patients).There significant differences ferritin, interleukin-...
Benidipine is an L, N and T type calcium channel blocker drug that widely used as antihypertensive drug.For the first time in literature, it was aimed to investigate effectiveness of benidipine controlling epileptic seizure preventing development neurodegeneration epilepsy.An experimentally epilepsy model produced with pentylenetetrazole, rats were divided into seven groups, different treatment doses or valproic acid combinations. The activities all recorded according Fisher&Kittner...
Acute lung injury (ALI) is an inflammation of the that results in increased vascular permeability, and can be caused by many different phenomena including COVID-19. Boron compounds have led to strong inhibition release inflammatory cytokines decrease coagulation factors both contributes COVID-19 related injury. So, this study, we investigate molecular histopathological effects inhaler boron use on LPS-induced ALI. In study ALI induced rats with LPS administration. Different doses inhaled...
Gadolinium deposition in biological tissues was first reported patients with renal failure. We aimed to investigate gadolinium the rat kidney after exposure single and multiple doses of evaluate for 1- 3-month periods. also determine any correlation between amount T1-weighted image intensity.
We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods. Rats were divided into 4 groups 8 rats each: one control (Sham), osteoporosis only (OP), two treated with Bose doses 50 100 mg/kg (OP+Bose50, OP+Bose100). Six weeks later, was administered for eight to animals undergoing ovariectomy. The left femoral bone evaluated in vitro after surgical removal. Bone mineral density (BMD) analyzed Dual-energy X-ray absorptiometry (DEXA)....
Aim: Renal ischemia-reperfusion injury (RI/RI) damages many organs, especially the kidney.Phosphodiesterase (PDE) 5 inhibitors has antioxidant and anti-inflammatory effects.Avanafil (AVA) is a second-generation PDE inhibitor with greater isoform selectivity.The aim of this study to investigate effects AVA on RI/RI in rats.Materials Methods: Forty rats were randomly divided into five groups (n=8): Sham; 10; RI/RI; + mg/kg AVA, 10 mg/ kg AVA.RI/RI was established by clamping renal artery.An...