Sepsis is an uncontrolled systemic infection, withcomplex pathophysiology that may result in acute lung organ damage and cause multiple failure. Although much research has been conducted to illuminate sepsis's complex pathophysiology, sepsis treatment protocols are limited, remains important of mortality andmorbidity intensive care units.Various studies have shown idebenone (IDE) possesses strong antioxidant properties, which inhibit lipid peroxidation protect cells from oxidative damage....

To study the potential nephroprotective role of agomelatine in rat renal tissue cases contrast-induced nephrotoxicity (CIN). The drug's action on antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels glutathione (GSH) malondialdehyde (MDA) gene expression interleukin-6 (IL-6), tumour necrosis factor (TNF)-α nuclear kappa B (NF-κB) was measured. Tubular hyaline haemorrhagic casts were also histopathologically evaluated.The institutional ethics local...

Abstract Objectives We investigated, the effects of aprepitant (APRE) on lung tissues rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly histopathologically. Methods A total 40 were divided into 5 groups 8 animals in each group. Group 1 (SHAM), control group; 2 (CLP), puncture; 3 (CLP + APRE10), administered CLP 10 mg/kg aprepitant; 4 APRE20), 20 APRE40), aprepitant. was induced CLP. After 16 h, taken for examination. Tumour...

Objective: Desloratadine is a biologically active metabolite of loratadine which indicated for the treatment allergic rhinitis.Bosentan dual endothelin receptor antagonist used to pulmonary artery hypertension (PAH).In this study, we aimed determine role endothelins in rhinitis (AR) and effects antagonists AR rat models through comparison with desloratadine. Methods:In total, 20 adult Sprague-Dawley rats were study.An ovalbumin-induced model was formed three study groups except control...

The aim of this study was to research the effects pregabalin on experimentally induced peripheral nerve crush injuries in rats.Forty-two adult female Wistar albino rats were divided into seven groups: 1st group: healthy; 2nd axonotmesis control; 3rd anastomosis 4th axonotmesis+30 mg/kg pregabalin; 5th axonotmesis+60 6th anastomosis+30 7th anastomosis+60 pregabalin. Evaluation sciatic functional index (SFI) performed one day before and days 7, 14, 21, 28 following surgery. right nerves all...

Abstract We aimed to evaluate the possible protective effect of a UTR antagonist and determine on ALT AST levels in serum, mRNA expression level , tumour necrosis factor‐alpha ( TNF ‐α) IL ‐1β SOD activity, GSH MDA liver tissues, which are important mediators or markers for hepatotoxicity animal model mice. Animals fasted overnight were divided into seven equal groups (n = 12). The first group was healthy (administered 0.1% DMSO intraperitoneally). Group 2 received only paracetamol PARA )...

We designed an experimental model of sepsis in rats to investigate the effects agomelatine (AGO) on lung tissues using molecular and histopathological methods.In our model, 32 were divided into 4 groups: group 1: control (HEALTHY); 2: lipopolysaccharide (LPS); 3: LPS plus 50 mg/kg AGO (LPS + AGO50); 4: 100 AGO100). An LPS-induced was performed replicate pathology sepsis. Rats from all groups killed after 12 hours, their lungs quickly collected. To therapeutic strategy, we evaluated tumor...

A sepsis model was created, induced by cecal ligation and puncture (CLP), in juvenile rat groups. Milrinone (MIL), which is known to have a modulatory effect on pro-inflammatory cytokines, administered the designated groups early period before severe developed. The study aimed at investigating possible protective effects of milrinone lung kidney tissues rats late phase sepsis.The pups were divided into seven with six animals each group: (1) healthy who received no drug; (2) CLP-S12...

Melatonin has an important role in regulating a variety of physiological functions the body. We investigated protective effects Agomelatine (AGO) and Ramelteon (RAME) on Endotoxin-Induced Uveitis (EIU) rats.70 rats were randomly divided into fourteen groups. Healthy group normal saline, (IP), (200 μg/kg lipopolysaccharide (LPS), SC), DEX LPS plus 1 mg/kg dexamethasone, IP), AGO20 received 200 20 AGO, AGO40 40 RAME2 2 RAME, RAME4 4 RAME. Each had two subgroups: 3rd 24th hr. The eye tissues...

Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose our study to determine expression 5-HT 7 receptors both in polyps healthy tissue subsequent aim compare patients with NP inferior turbinate (control).The included 60 participants (40 20 controls) aged 35 62 years. polyp samples were collected from all relative receptor analyses performed. RT-PCR analysis control identified cavities controls. This was approximately 67 times higher...

This study focused on delineating the possible effects of roflumilast (ROF), a selective phosphodiesterase 4 (PDE4) inhibitor, in rats with cecal ligation and puncture (CLP)-induced polymicrobial sepsis, investigated whether ROF can act as protective agent sepsis-induced lung damage.Four experimental groups were organized, each comprising eight rats: Control, Sepsis, Sepsis + 0.5 mgkg-1, 1 mgkg-1 groups. A sepsis model was induced by under anesthesia. Twelve hours after induction, lungs...

We examined the antiosteoporotic effect of bosentan (Bose) by radiographic, histopathological, and molecular methods. Rats were divided into 4 groups 8 rats each: one control (Sham), osteoporosis only (OP), two treated with Bose doses 50 100 mg/kg (OP+Bose50, OP+Bose100). Six weeks later, was administered for eight to animals undergoing ovariectomy. The left femoral bone evaluated in vitro after surgical removal. Bone mineral density (BMD) analyzed Dual-energy X-ray absorptiometry (DEXA)....

We investigated the effect of ebselen on fracture healing in an experimental model.We divided rats into two groups, 6 each: femur control group and treatment with fracture. In group, we created only administered creating intraperitoneally at 5 mg/kg once daily for 1 month after 1st day group. evaluated recovery status fractured femurs end radiographic, histopathological, immunohistochemical methods.According to radiographic scores, increased extent new bone formation cartilage callus...

Pomegranate peel contains bioactive ingredients such as flavonoids, ellagitannins, phenolics and proanthocyanidin compounds with high antioxidant activity. has antiapoptotic, anti-inflammatory effects due to its punicalagin content. We aimed determine the effect of pomegranate extract (PPE) on lipopolysaccharide (LPS)-induced uveitis. Sixty rats were seperated randomly into twelve groups (n = 5). The healthy group received intraperitoneal normal saline, uveitis 200 μg/kg LPS, dexamethasone...

Aim: Melatonin promoted osteoblast differentiation and causes an increase in levels of markers bone proliferation. Ramelteon (RAMEL) activates melatonin receptors binds to these as non-selective. In this study, we investigated the preventive effects agonist RAMEL on osteoporosis by radiological, histological, molecularly.Methods: Groups 1: Control, Group 2: Osteoporosis: Overectomized group (OP), 3: OP + ramelteon 2 mg/kg, 4: 4 mg/kg. 24 animals underwent bilateral ovariectomy. was...

Introduction:Sepsis is a life-threatening excessive systemic inflammatory reaction syndrome to infection that usually occurs in patients with bacteremia.The respiratory system one of the structures most affected by acute organ damage.Melatonin plays an important role regulating various physiological functions body, including antioxidant and antiinflammatory.Ramelteon (RAME) first melatonin receptor agonist confirmed for clinical use.The goal this study determine effects RAME on...