A5032877525- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ultrasound and Hyperthermia Applications
- Bladder and Urothelial Cancer Treatments
- Glutathione Transferases and Polymorphisms
- bioluminescence and chemiluminescence research
- Porphyrin and Phthalocyanine Chemistry
- Laser Applications in Dentistry and Medicine
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cervical Cancer and HPV Research
- Pediatric Hepatobiliary Diseases and Treatments
- Laser Design and Applications
- Oral health in cancer treatment
- Advanced Radiotherapy Techniques
- Skin Protection and Aging
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
Prokhorov General Physics Institute
2019-2024
Moscow Engineering Physics Institute
2019-2024
Institute of Engineering Physics
2022
Russian Academy of Sciences
2022
Cervical cancer (CC) occupies a leading position in incidence among young women of reproductive age. In this connection, it is urgent to search for the most effective approaches diagnosis and treatment pathology. The purpose study was evaluate effectiveness PDT method using Cе6 with control photobleaching video spectral fluorescence diagnostic methods, develop fluorescence-assisted systemic photodynamic therapy mediated chlorin e6 CIN 3 CIS.
The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of tumor using chlorin-type photosensitizers (PSs). Lack chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Phototheranostics includes spectral-fluorescence diagnostics Ce6 distribution in NIR range with simultaneous assessment flow. Fluorescence were performed single laser λexc=660±5 nm. Combined spectroscopic allowed estimation...
(1) Purpose: Improving the treatment effectiveness of intraepithelial neoplasia cervix associated with human papillomavirus infection, based on application method photodynamic therapy simultaneous laser excitation fluorescence to clarify boundaries cervical neoplasms. (2) Methods: Examination and 52 patients aged 22 53 years morphologically cytologically confirmed mild severe neoplasia, preinvasive, micro-invasive, squamous cell carcinoma. All were carriers infection. The underwent...
The paper presents the results of literature data analysis on main directions precancerous diseases cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects, destruction normal tissue. In addition, use traditional methods cause multidrug resistance, which will ineffective development a relapse disease. To avoid toxicity reduce alternative strategies have been...
(1) Purpose: To investigate the efficacy and safety of using PDT in treatment severe intraepithelial squamous lesions cervix preinvasive cervical cancer associated with HPV women reproductive age. (2) Methods: The examination 45 patients aged 22-49 years morphologically confirmed HPV-associated neoplasia a degree (17 patients) (28 were performed. All underwent chlorin e6 photosensitizer; after which, affected areas evaluated video spectral fluorescence diagnostics. effectiveness was assessed...
Abstract The main problem in the photodynamic therapy (PDT) of tumors is insufficient light exposure to tissue or appearance undesirable surface effects. reason irregular distribution absorbed dose by depth. influence spot diameter on relative fluence rate near-surface layer cervical was studied Monte Carlo simulation. Photodynamic with chlorine-type photosensitizer (PS) carried out model laser 660 nm at same power density a change from 5 15 mm and radiation energy 100 300 J cm −2 ....
This study aimed to evaluate the method of fluorescence diagnostics using developed video-fluorescent equipment with laser excitation and assessment effectiveness photodynamic therapy via photobleaching chlorin e6. The boundaries precancerous conditions cervical neoplasms were established then clarified spectral-fluorescent diagnostics. At a photosensitizer dose 0.8–1.2 mg kg−1, images cervix contrasted well in pathological tissue compared normal surrounding tissue. made it possible estimate...
Abstract This study aims to conduct a comparative analysis of aminolevulinic acid and its hexyl aminolevulinate (HAL) for photodynamic diagnostics therapy cervical dysplasia vulvar leukoplakia in continuous pulsed laser irradiation mode. The fluorescence intensity protoporphyrin IX (PpIX) the cervix epithelium was five times higher after application HAL compared with acid. Increased PpIX tissues complicated by not observed 5-aminolevulinic HAL. Intraepithelial changes patients were absent...
The combined use of fluorescence diagnostics (FD) and photodynamic therapy (PDT) is a promising approach to the treatment cholangiocarcinoma. Information about probing depth laser radiation at therapeutic dose sufficient for appearance effect allows planning PDT process. We aim assess dose. highest intensity observed in gall bladder liver tissues. A significant difference was noted backscattered radiation, depending on segments wild boar hepatobiliary system. Analysis (λ = 660 nm) revealed...
The main problem in the photodynamic therapy of tumors is insufficient light exposure to tissue depth or appearance undesirable surface effects. It required investigate influence energy density and radiation spot diameter on photosensitizer photobleaching efficiency by depth. Optimization parameters for laser-induced cervical tissues was conducted using numerical simulation fluorescent navigation. laser fluence rate near-surface layer increases relative incident with increasing range from...
The paper presents the results of precise fluorescent diagnostics cervical neoplasms at photodynamic therapy using a photosensitizer, chlorin e6 (Photolon). supposes combined use spectral and video pathological normal tissues. A fiber spectrometer with excitation photosensitizer fluorescence by He-Ne laser (λ = 632.8 nm) semiconductor 660 was used for diagnostics. two-channel system showed that accumulation level in tissues is 4- 8 times higher than images applied dose had high contrast...
This work presents the developed method and equipment for assessing effectiveness of treatment using photodynamic therapy (PDT). As a photosensitizer (PS), drugs "Photoditazin" "Alasens" were used. The problem spectral separation laser radiation fluorescence 5-ALA-induced protoporphyrin IX or Chlorin e6 was solved by selecting combination optical filters. time irradiation varied from 6 to 20 min, depending on index irradiated area, energy dose 100-200 J/cm <sup...