A5010774833- Head and Neck Cancer Studies
- Nuclear Physics and Applications
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Dental Radiography and Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Cultural Heritage Materials Analysis
- Oral and Maxillofacial Pathology
- Monoclonal and Polyclonal Antibodies Research
- Periodontal Regeneration and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Bone health and treatments
- Bone and Joint Diseases
- Cutaneous Melanoma Detection and Management
- Cancer-related Molecular Pathways
- Oral health in cancer treatment
- Oral and gingival health research
- Renal Transplantation Outcomes and Treatments
- Craniofacial Disorders and Treatments
- Ear and Head Tumors
- Brain Metastases and Treatment
Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
2020-2024
Universitätsklinikum Würzburg
2015-2024
DePaul University
2024
Hospital Israelita Albert Einstein
2024
Universidad Nacional Autónoma de México
2024
Stanford University
2024
University of Alberta
2024
University of Lübeck
2024
Barnet and Chase Farm NHS Hospitals Trust
2024
Royal Free London NHS Foundation Trust
2024
Abstract In this study, we aimed to develop a novel prognostic algorithm for oral squamous cell carcinoma (OSCC) using combination of pathogenomics and AI-based techniques. We collected comprehensive clinical, genomic, pathology data from cohort OSCC patients in the TCGA dataset used machine learning deep algorithms identify relevant features that are predictive survival outcomes. Our analyses included 406 patients. Initial involved gene expression analyses, principal component enrichment...
While [18F]-fluorodeoxyglucose ([18F]FDG) is the standard for positron emission tomography/computed tomography (PET/CT) imaging of oral squamous cell carcinoma (OSCC), diagnostic specificity hampered by uptake in inflammatory cells such as neutrophils or macrophages. Recently, molecular probes targeting fibroblast activation protein α (FAP), which overexpressed a variety cancer-associated fibroblasts, have become available and might constitute feasible alternative to FDG PET/CT.Ten...
Abstract: Extracorporeal human lymphatic organs are expected to be excellent tools in the study of molecular and cellular bases immunologic balance tissue harmony. A rational approach process design a device procedure recreate lymph node environment vitro is described with emphasis on T‐cell activation. Based this approach, bioreactor supporting self‐assembly tissues due proper emulation architecture homeostasis could developed.
The spectrum of indications for the use membranes and scaffolds in field oral maxillofacial surgery includes, amongst others, guided bone regeneration (GBR). Currently available membrane systems face certain disadvantages such as difficult clinical handling, inconsistent degradation, undirected cell growth a lack stability that often complicate their application. Therefore, new which can overcome these issues are great interest this field. In pilot study, we investigated polycaprolactone...
Purpose: Human papillomavirus (HPV) 16 plays an etiologic role in a growing subset of head and neck squamous cell carcinomas (HNSCC), where viral expression the E6 E7 oncoproteins is necessary for tumor growth maintenance. Although patients with HPV+ tumors have more favorable prognosis, there are currently no HPV-selective therapies. Recent studies identified differential receptor tyrosine kinase (RTK) profiles versus HPV- tumors. One such RTK, HER3, overexpressed interacts...
Study Objective. To quantify the influence of a high‐fat meal on oral bioavailability immunosuppressant everolimus in single‐dose study healthy subjects and to confirm results small food‐effect screening assessment patients with renal transplants who were receiving multiple‐dose everolimus. Design. Randomized, open‐label, crossover, confirmatory screening. Setting. Phase 1 unit for two German hospitals patient Subjects. Twenty‐four male volunteers; six clinically stable originally part phase...
Many important cultural and religious objects from Asia consist of outer metallic shapes, usually bronze, which fully enclose inner contents made organic materials such as wood, bark, paper, textile, plants others. Bronze other materials, copper silver, are generally more transparent to neutrons than X‐rays. However, less X‐rays therefore enclosed by can be visible with neutrons. Therefore, neutron imaging (radiography tomography) was found an ideal tool for the inspection that metal outside...
Distinct evolution of fruit microstructure under different drying conditions were identified using a 3D imaging and Eulerian–Lagrangian analysis.
Squamous cell carcinoma (SCC) of the oral cavity is one most common tumor entities worldwide. Precise initial staging necessary to determine a diagnosis, treatment, and prognosis.To examine diagnostic accuracy preoperative 18-F fluorodeoxyglucose (FDG) positron emission tomographic/computed tomographic (PET/CT) imaging in detecting cervical lymph node metastases.This prospective study was performed at single tertiary reference center between June 1, 2013, January 31, 2016. Data were analyzed...
A number of cross-sectional epidemiological studies suggest that poor oral health is associated with respiratory diseases. However, the cases within was limited, and had different measurement conditions. By analyzing data from National Health Nutrition Examination Survey III (NHANES III), this study aimed to investigate possible associations between chronic obstructive pulmonary disease (COPD) periodontitis in general population. COPD diagnosed where FEV (1)/FVC ratio below 70% (non-COPD...
(1) Background: Evaluation of impact adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma the cavity/oropharynx (OSCC) up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group clinical follow-up was chosen for control, survival quality life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included resected OSCC (pT1/pT2, pN1, cM0) who allocated into or observation. The primary endpoint...
The aim of this study was to investigate the jawbone concentration clindamycin (CLI) in patients with an osteonecrosis jaw (ONJ). Patients medication-related ONJ [MRONJ] and osteoradionecrosis [ORN]) antibiotic treatment CLI were included. Plasma, vital necrotic bone samples collected. Plasma analyzed by liquid chromatography–tandem mass spectrometry. MRONJ exhibited a mean plasma 9.6 μg/mL (SD ± 3.6 μg/mL) concentrations 2.3 μg/g 1.4 μg/g) 2.1 2.4 samples, without statistical significance...
Abstract Background Oral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone frequently present. Computed tomography (CT) magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, accuracies in detecting these affections patients suffering from OSCC. To date, existing data regarding impact cone-beam computed (CBCT) been weak. Therefore, this study aimed investigate whether CBCT a suitable tool detect...
Introduction Recent advancements in treatment approaches for oral squamous cell carcinomas (OSCCs) necessitate a reevaluation of neck dissection techniques and their impact on patient outcomes morbidity. Methods This retrospective study 250 OSCC patients recruited between 2017–2022 examined the association survival metrics. Our cohort, drawn from primary surgery population at our clinic, provided rich dataset encompassing demographics, clinical parameters, detailed surgical records. Two were...
OBJECTIVE: To assess the influence of CYP3A4 enzyme inducer rifampin on pharmacokinetics immunosuppressant everolimus to provide guidance for their coadministration. METHODS: In this open-label, single-sequence, crossover study, 12 healthy subjects received a single oral 4-mg dose alone and again after an 8-day pretreatment with 600 mg/d. Urinary excretion 6β-hydroxycortisol was measured at various time points during treatment as marker induction. RESULTS: Urine significantly elevated...
Fingolimod [(FTY720), Gilenya; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol], a new drug for the treatment of relapsing multiple sclerosis, acts through its phosphate metabolite, which modulates sphingosine 1-phosphate receptors. This represents novel mechanism action. In present work, absorption and disposition <sup>14</sup>C-labeled fingolimod were investigated in healthy male volunteers after single oral dose 4.5 mg. Total radioactivity was determined blood, urine, feces. quantified...
Japanese blades are culturally interesting objects both from the stylistic point of view and because their fantastic performance. In this work, we present new results, using a non-invasive approach, concerning these peculiar artefacts. Five swords pertaining to Koto (987–1596) Shinto (1596–1781) periods have been analysed through white beam energy resolved neutron-imaging techniques. The experiments performed at ICON line, operating spallation neutron source SINQ, Paul Scherrer Institut in...
Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise the oropharynx, where viral expression E6 E7 oncoproteins promote cellular transformation, tumor growth, maintenance. An important oncogenic signaling pathway activated by PI3K pathway, a key driver carcinogenesis. The also mutation or amplification PIK3CA over half HPV(+) HNSCC. In this study, we investigated efficacy PI3K-targeted therapies HNSCC preclinical...