A5055336306- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Forensic Anthropology and Bioarchaeology Studies
- Pleistocene-Era Hominins and Archaeology
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Microbial Metabolic Engineering and Bioproduction
- Biomedical and Engineering Education
- Photoreceptor and optogenetics research
- Origins and Evolution of Life
- Evolution and Genetic Dynamics
- Ancient Near East History
- Neuroscience and Neuropharmacology Research
- Protist diversity and phylogeny
- Animal Diversity and Health Studies
- Bioinformatics and Genomic Networks
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Archaeology and ancient environmental studies
- Cell Image Analysis Techniques
University of Wisconsin–Madison
2021-2025
University of Arizona
2020-2021
Middle East Technical University
2017-2018
The social organization of the first fully sedentary societies that emerged during Neolithic period in Southwest Asia remains enigmatic,1Kuijt I. People and Space Early Agricultural Villages: Exploring Daily Lives, Community Size, Architecture Late Pre-Pottery Neolithic.J. Anthropol. Archaeol. 2000; 19: 75-102https://doi.org/10.1006/jaar.1999.0352Crossref Scopus (125) Google Scholar mainly because material culture studies provide limited insight into this issue. However, Anatolian...
Abstract For billions of years, life has continuously adapted to dynamic physical conditions near the Earth’s surface. Fossils and other preserved biosignatures in paleontological record are most direct evidence for reconstructing broad historical contours this adaptive interplay. However, dating earliest history exceedingly rare. Here, we combine phylogenetic inference primordial rhodopsin proteins with modeled spectral features Precambrian Earth environment reconstruct paleobiological...
Abstract Translation is an essential attribute of all living cells. At the heart cellular operation, it a chemical information decoding process that begins with input string nucleotides and ends synthesis specific output peptides. The translation interconnected gene expression, physiological regulation, transcription, responses to signaling molecules, among other functions. Foundational efforts have uncovered wealth knowledge about mechanistic functions many interactions between components...
Neanderthals contributed genetic material to modern humans via multiple admixture events. Initial events presumably occurred in Western Asia shortly after migrated out of Africa. Despite being a focal point admixture, earlier studies indicate lower Neanderthal introgression rates some Asian populations as compared with other Eurasian populations. To better understand the genome-wide and phenotypic impact region, we sequenced whole genomes nine present-day Europeans, Africans, Druze at high...
Abstract Protein translation is a foundational attribute of all living cells. The function carried out by the ribosome critically depends on an assortment protein interaction partners, collectively referred to as machinery. Various studies suggest that diversification machinery occurred prior last universal common ancestor, yet it unclear whether predecessors extant factors were functionally distinct from their modern counterparts. Here we reconstructed shared ancestral trajectory and...
Translation is an essential attribute of all living cells. At the heart cellular operation, it a chemical information decoding process that begins with input string nucleotides and ends synthesis specific output peptides. The translation interconnected gene expression, physiological regulation, transcription, responses to signaling molecules, among other functions. Foundational efforts have uncovered wealth knowledge about mechanistic functions components their many interactions between...
Synonymous mutations are changes to DNA sequence, which occur within translated genes but do not affect the protein sequence. Although often referred as silent mutations, evidence suggests that synonymous can gene expression, mRNA stability, and even translation efficiency. A collection of both experimental bioinformatic data has shown impact cell phenotype, yet less is known about molecular mechanisms potential beneficial or adaptive effects such evolved populations. Here, we report a...
Translation is a foundational biological process that decodes genetic information provided by an mRNA template. Over the past decade major advancements have been made towards understanding origins and early evolution of translation. There remain two critical gaps: First, we lack coherent view how translation factors emerged co-evolved to regulate cellular protein synthesis. Second, know little about evolutionary environmental basis variation complexity across tree life. Here present...
Development of workflows for NGS data analysis have facilitated the study sequences. Such their own advantages and challenges based on algorithms they use. As a part this Biohackathon 2020, we compared SARS-CoV-2 variant outputs INSaFLU workflow with those analyzed by galaxyproject/SARS-CoV-2. Within 24 samples, 597 variants were found to be shared between two workflows, almost half them within coding sequence replicase polyprotein 1ab. variants, number non-synonymous considerably higher...
Abstract Synonymous mutations are changes to DNA sequence that occur within translated genes but which do not affect the protein sequence. Although often referred as silent mutations, evidence suggests synonymous can gene expression, mRNA stability, and even translation efficiency. A collection of both experimental bioinformatic data has shown impact cell phenotype, yet less is known about molecular mechanisms potential beneficial or adaptive effects such evolved populations. Here, we report...
ABSTRACT For billions of years, life has continuously adapted to dynamic physical conditions near the Earth’s surface. Fossils and other preserved biosignatures in paleontological record are most direct evidence for reconstructing broad historical contours this adaptive interplay. However, dating earliest history exceedingly rare. Here, we combine phylogenetic inference primordial rhodopsin proteins with modeled spectral features Precambrian Earth environment reconstruct paleobiological...