A5088392079- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Non-Invasive Vital Sign Monitoring
- Neuroscience of respiration and sleep
- Coenzyme Q10 studies and effects
- Cardiovascular Syncope and Autonomic Disorders
- Physical Activity and Health
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
- Body Composition Measurement Techniques
- Elasticity and Material Modeling
- Sleep and related disorders
University of Toronto
2015-2024
Hospital for Sick Children
2014-2024
SickKids Foundation
2015-2024
Toronto Public Health
2013-2021
Federazione Medico Sportiva Italiana
2011
Bambino Gesù Children's Hospital
2007-2010
Cambridge University Press
2009
University of Rome Tor Vergata
2008
To evaluate the prevalence of structural cardiac lesions using echocardiography in apparently healthy boys referred for pre-participation screening (PPS).3100 male soccer players were evaluated by addition to standard PPS.In 56 subjects (1.8%), a lesion with potential future complication was detected. Specifically, hypertrophic cardiomyopathy (HCM) found two boys; bicuspid aortic valve (BAV) 24; mitral prolapse 10 and atrial septal defects (ASDs) 20. Resting physical examination (PE) failed...
The objective of this study was to quantify imaging markers myocardial fibrosis and assess function in long-term transposition the great arteries survivors after arterial switch operation (ASO).Paediatric ASO patients were prospectively studied by cardiac magnetic resonance imaging, including first-pass perfusion, late gadolinium enhancement, T1 relaxometry, as well echocardiography for left ventricular (LV) systolic diastolic strain analysis, with comparison healthy controls. Thirty (mean...
We designed our study to investigate the efficacy of a new therapeutic approach late onset hypertension in patients after surgical repair aortic coarctation. Several studies have shown higher incidence during daily activities, and exercise, correction To best knowledge, however, no data exists concerning haemodynamics, response arterial pressures, effects medications for lowering blood pressure exercise or activities.We studied 128 patients, aged 15.6 +/- 4.3 years, determine as we...
Neonatal repair has completely changed the clinical history of patients with tetralogy Fallot (ToF); however, these carry a significant risk severe arrhythmias and sudden cardiac death in long term. The exact mechanism for late is multifactorial still not well defined, stratification primary prophylaxis remains challenging. Cardiopulmonary exercise testing (CPET) well-established safe method to assess cardiopulmonary function children adults congenital heart disease. Several parameters...
Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence anesthetic triggers. The objective this exploratory study was elucidate pathophysiology tested positive for MH caffeine-halothane contracture test. To end, we used phosphorus magnetic resonance spectroscopy, blood oxygen...
Abstract Objective To characterize the clinical presentation of sleep‐disordered breathing and respiratory patterns at rest during a 6‐min walk test (6MWT) in children with rapid‐onset obesity, hypothalamic dysfunction, hypoventilation, autonomic dysregulation (ROHHAD) syndrome. Methods Retrospective study ROHHAD who had diagnostic baseline polysomnography, daytime cardiorespiratory monitoring 6MWT. Polysomnography data were also compared body mass index‐, age‐, sex‐matched controls. Results...
Summary The aortic pulse wave velocity ( PWV ) measured via cardiac magnetic resonance CMR can be used to non‐invasively assess changes in arterial stiffness and potential underlying vascular dysfunction. This technique could unmask early dysfunction overweight obese youth at risk for cardiovascular disease. We sought determine the association between stiffness, percentage body fat, mass index BMI ), function adolescents across weight spectrum through both standard applanation tonometry AT...
Cardiac monitoring for children with heart disease still employs common clinical techniques that require visits to hospital either in an ambulatory or inpatient setting. Frequent cardiac monitoring, such as rate can limit children's physical activity and quality of life. The main objective this study is evaluate the performance a textile-based device (SKIIN) measuring (HR) different tasks: lying down, sitting, standing, exercising, cooling down.Twenty participants including healthy were...
Right ventricular (RV) dysfunction is a common problem after heart transplant (HTx). In this study, we used semi-supine bicycle ergometry (SSBE) stress echocardiography to evaluate RV systolic and diastolic reserve in paediatric HTx recipients. Thirty-nine pediatric recipients 23 controls underwent stepwise SSBE echocardiography. Colour tissue doppler imaging (TDI) peak (s') (e') velocities, myocardial acceleration during isovolumic contraction (IVA), free wall longitudinal strain were...
Abstract Background Previous studies have shown evidence of hypoxemia and hypercapnia during cardiopulmonary exercise test (CPET) evaluation in children with congenital central hypoventilation syndrome (CCHS). However, there are no longitudinal which compared CPET findings to polysomnogram (PSG) or PHOX2B mutation, date. Objectives To describe the a cohort CCHS correlate PSG results. Methods This retrospective study was conducted followed Long‐term Ventilation Program at SickKids, Toronto,...
Despite exercise intolerance being predictive of outcomes in pulmonary arterial hypertension (PAH), its underlying cardiac mechanisms are not well described. The aim the study was to explore biventricular response and associations with cardiorespiratory fitness children PAH. Participants underwent incremental cardiopulmonary testing simultaneous echocardiography on a recumbent cycle ergometer. Linear mixed models were used assess function variance between metabolic parameters during...
Background: Physical activity (PA) is a mainstay for cardiovascular health. However, those with hypertrophic cardiomyopathy (HCM) are often counselled to limit PA due the potential risk of sudden cardiac death. The emphasis placed on restriction has put this population more susceptible acquired (CV) factors, and poor long-term CV health from physical inactivity. To date, no consensus exists about what appropriate safe in terms exercise population. Project Aim: Use modified Delphi method gain...
Abstract Magnetic Resonance Imaging (MRI) is well‐suited for imaging peripheral blood flow due to its non‐invasive nature and excellent spatial resolution. Although MRI routinely used in adults assess physiological changes chronic diseases, there are currently no MRI‐based data quantifying arterial pediatric or adolescent populations during exercise. Therefore the current research sought document femoral at rest following exercise a pediatric‐adolescent population using phase contrast MRI,...