A5067875437- Antibiotics Pharmacokinetics and Efficacy
- Stress Responses and Cortisol
- Resilience and Mental Health
- Mental Health Treatment and Access
- Psychological Well-being and Life Satisfaction
- Sports Performance and Training
- Employment and Welfare Studies
- Child and Adolescent Psychosocial and Emotional Development
- Health and Well-being Studies
- Mental Health Research Topics
- Mental Health and Psychiatry
- Migraine and Headache Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Health and Conflict Studies
- Antimicrobial Resistance in Staphylococcus
- Mindfulness and Compassion Interventions
- Spine and Intervertebral Disc Pathology
- Counseling Practices and Supervision
- Attachment and Relationship Dynamics
- Family Dynamics and Relationships
- Cardiac Health and Mental Health
- Psychosomatic Disorders and Their Treatments
- Digital Mental Health Interventions
- Epigenetics and DNA Methylation
- Cognitive Abilities and Testing
Boehringer Ingelheim (Germany)
2024-2025
Freie Universität Berlin
1996-2022
AstraZeneca (Sweden)
2019-2020
University of California, Irvine
2012-2020
University College London
2012
University of California, Davis
2007-2008
Napa State Hospital
2008
Although the construct of psychopathy is related to community violence and recidivism in various populations, empirical evidence suggests that its association with institutional aggression weak at best. The current study examined, via both variable-level group-level analyses, relationship between standard risk instruments, which included a measure psychopathy, violence. Additionally, incremental validity dynamic factors also was examined. results suggest PCL-R only weakly then when...
Abstract Actuarial violence risk assessments, many of which include the construct psychopathy, have been shown to be superior clinical judgment in prediction long‐term community and recidivism. While these instruments initially appeared provide similarly accurate judgments institutional aggression, recent research has indicated that such assessments may less robust this setting. One explanation lie types aggression most frequently observed each Impulsive (or reactive/affective) is type...
Cefazolin is used as a prophylactic antibiotic to reduce surgical site infections (SSIs). Obesity has been identified risk factor for SSIs. dosing recommendations and guidelines are currently inconsistent obese patients. As plasma target-site exposure might differ, pharmacokinetic data from the sites of SSIs essential evaluate treatment efficacy: these can be obtained via tissue microdialysis. This analysis was designed need adaptations in patients prophylaxis. Data 15 (BMImedian = 52.6 kg...
Objectives: Model-based exposure-response (ER) analyses are a cornerstone of dose optimization in the Project Optimus era oncology drug development. Yet, during cancer clinical trials, it is often necessary to perform modifications (dose interruption, reduction, or discontinuation) due safety and tolerability issues [1]. This leads feedback dose-exposure-safety relationship, where outcomes have an impact on dose. Failure account for this standard model-based ER may lead unrealistic...
Brigimadlin (BI 907828) is a potent, oral MDM2-p53 antagonist under clinical investigation for the treatment of advanced solid tumours. A brigimadlin exposure-tumour growth inhibition (E-TGI) model was developed to support recommended phase II dose (RP2D) selection in future trials. Population modelling applied analyse longitudinal tumour size (sum longest diameters, SLD) data 151 patients from I trial treated with 5-80 mg every third or fourth week (q3w/q4w). The impact exposure on...
Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Adequate dosing antimicrobial therapy is central importance to improve outcome. Liver may alter antibiotic drug concentrations via changes distribution elimination. We studied the pharmacokinetics meropenem in critically ill patients with ACLF during continuous veno-venous hemodialysis (CVVHD) compared it without concomitant (NLF).In this prospective cohort study, received 1 g tid short-term infusion (SI)....
Stress-reduction interventions have been linked with enhanced well-being and health. This study examined affect cortisol in 111 individuals randomly assigned to a single 35-minute guided relaxation or stress management lecture control group. Positive increased more the compared group ( F = 6.62, p .01). Dispositional reactivity had moderating influence R 2 .248, < .001), such that high showed highest increases positive relaxation. Results indicate intervention improves among reactivity.
Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients. However, data characterizing pharmacokinetics (PK) and assessing whether effective concentrations are reached at target site lacking. We hypothesized that current dosing regimens do not lead to plasma interstitial fluid (ISF) subcutaneous obese Methods: As a controlled clinical model, non-obese patients undergoing intra-abdominal surgery received 600 mg linezolid as single infusion....
Background: This controlled clinical study aimed to investigate the impact of obesity on plasma and tissue pharmacokinetics meropenem. Methods: Obese (body mass index (BMI) ≥ 35 kg/m2) age-/sex-matched nonobese (18.5 kg/m2 BMI ≤ 30 surgical patients received a short-term infusion 1000-mg Concentrations were determined via high performance liquid chromatography-ultraviolet (HPLC-UV) in microdialysate from interstitial fluid (ISF) subcutaneous up eight h after dosing. An analysis was performed...
We theorized that sociocultural contexts characterized by a form of interdependence emphasizes mutual obligations, emotional positivity, and readily accessible social support from family may maximize the benefits support. This characterizes Latino culture is captured cultural value familism. Eighty-six non-Latino participants completed measures familism perceived before taking part in standardized laboratory stress task elicits cortisol reactivity. Cortisol reactivity an indicator bodily...
Neuroticism is the heritable and stable personality trait defined by tendency to experience negative emotion, be easily stressed, slow soothe. poses a risk for poor social health outcomes that has been identified as major public concern. To date, factors attenuate neuroticism's costs have not identified. The goal of this work was test hypothesis neuroticism would attenuated in sociocultural contexts emphasize readily accessible support, emotional positivity, physical proximity interdependent...
To quantitatively compare pharmacokinetics (PK) and the exposure-response (ER) relationship of sodium-glucose cotransporter-2 inhibitor, dapagliflozin, between adolescents/young adults with type 1 diabetes mellitus (T1DM).
Systematic comparison of analysis methods clinical microdialysis data for impact on target-site drug exposure and response.39 individuals received a 500 mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma microdialysate collection interstitial space fluid (ISF). ISF concentrations were leveraged using non-compartmental (NCA) compartmental (CA) via (ii) relative recovery correction at midpoint the interval (midpoint-NCA, midpoint-CA) dialysate-based integrals time...
The most suitable method for predicting the glomerular filtration rate (GFR) in obesity is currently debated. Therefore, multiple GFR/creatinine clearance prediction methods were applied to (morbidly) obese and nonobese patients ranging from moderate renal impairment hyperfiltration their predictions rated based on observed fosfomycin pharmacokinetics, as this model drug exclusively eliminated via filtration.The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Modification of...
The objectives of this study were the identification in (morbidly) obese and nonobese patients (i) most appropriate body size descriptor for fosfomycin dose adjustments (ii) adequacy currently employed dosing regimens. Plasma target site (interstitial fluid subcutaneous adipose tissue) concentrations after administration (8 g) to 30 surgery (15 obese/15 nonobese) obtained from a prospective clinical trial. After characterization plasma microdialysis-derived pharmacokinetics via population...
A quantitative evaluation of the PK meropenem, a broad-spectrum β-lactam antibiotic, in plasma and interstitial space fluid (ISF) subcutaneous adipose tissue obese patients is lacking as date. The objective this study was characterisation meropenem population pharmacokinetics ISF non-obese for identification adequate dosing regimens via Monte-Carlo simulations. We obtained microdialysate concentrations after administration 1000 mg to 15 surgery from prospective clinical trial. After...