A5091419957- Viral Infections and Vectors
- interferon and immune responses
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Mosquito-borne diseases and control
Australian Regenerative Medicine Institute
2022-2024
Monash University
2022-2024
Abstract cGAS‐STING signalling is induced by detection of foreign or mislocalised host double‐stranded (ds)DNA within the cytosol. STING acts as major hub, where it controls production type I interferons and inflammatory cytokines. Basally, resides on ER membrane. Following activation traffics to Golgi initiate downstream subsequently endolysosomal compartments for degradation termination signalling. While known be degraded lysosomes, mechanisms controlling its delivery remain poorly...
Stimulator of Interferon Genes (STING) is a cytosolic sensor cyclic dinucleotides (CDNs). The activation dendritic cells (DC) via the STING pathway, and their subsequent production type I interferon (IFN) considered central to eradicating tumours in mouse models. However, this contribution preclinical murine studies has not translated into positive outcomes agonists phase & II clinical trials. We therefore questioned whether difference human DC responses could be critical lack...