A5048527755- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Viral Infectious Diseases and Gene Expression in Insects
Taibah University
2023
University of Birmingham
2021
The adenovirus C5 E1B-55K protein is crucial for viral replication and expressed early during infection. It can interact with E4orf6 to form a complex that functions as ubiquitin E3 ligase. This targets specific cellular proteins marks them ubiquitination and, predominantly, subsequent proteasomal degradation. interacts various proteins, p53 being the most extensively studied, although identifying binding sites has been challenging. To explain diverse range of associated E1B-55K, we...
The adenovirus 12 early region 1B55K (Ad12E1B55K) protein has long been known to cause non-random damage chromosomes 1 and 17 in human cells. These sites, referred as Ad12 modification have marked similarities classic fragile sites. In the present report we investigated effects of Ad12E1B55K on cellular DNA response replication, considering our increased understanding pathways involved. We compared skin fibroblasts expressing (55K