A5058993950- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Sepsis Diagnosis and Treatment
- Poisoning and overdose treatments
- COVID-19 and healthcare impacts
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Public Health in Brazil
- Vasculitis and related conditions
- Cardiac Arrest and Resuscitation
- Climate Change and Health Impacts
- Drug-Induced Hepatotoxicity and Protection
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Healthcare Decision-Making and Restraints
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Renal Diseases and Glomerulopathies
- Renal function and acid-base balance
- Drug-Induced Adverse Reactions
- Medical Malpractice and Liability Issues
Universidade Estadual Paulista (Unesp)
2016-2025
Medecell (Brazil)
2020-2024
Universidade de São Paulo
2021-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
Renal involvement is frequent in COVID-19 (4-37%). This study evaluated the incidence and risk factors of acute kidney injury (AKI) hospitalized patients with COVID-19. Methodology: represents a prospective cohort public tertiary university hospital São Paulo, Brazil, during first 90 days pandemic, followed up until clinical outcome (discharge or death). Results: There were 101 COVID-19, which 51.9% admitted to intensive care unit (ICU). The overall AKI was 50%; 36.8% had hematuria...
Introduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America Caribbean, we performed a study with aim to contribute improve its better understanding. Methods Observational, prospective, longitudinal, multinational cohort addressed determine risk factors, clinical profile, process care outcomes AKI region. Patients meeting KDIGO definition were included over 9-month period...
Acute Kidney Injury (AKI) is a common clinical syndrome characterized by an abrupt decline in the glomerular filtration rate (GFR), which can cause severe alterations blood volume and acid-base balance. Drug-Induced (DI-AKI) associated with exposure to nephrotoxic medications, particularly among hospitalized patients. Adverse drug reactions comprises type A B reactions. Type are predictable based on pharmacology of substance, dose-dependent, manifest as Tubular Necrosis (ATN). unpredictable,...
This article presents a case of rapidly progressive glomerulonephritis following the Oxford-AstraZeneca COVID-19 vaccine in female patient 58 years old. After 5 days, she presented fatigue, paleness, arthralgia on hands, knees, ankles, foamy urine, and elevated blood pressure. Exams showed serum creatinine 2.2 mg/dL (baseline 1.0 mg/dL). Urinalysis revealed hematuria, her 24-h urinary protein excretion was 4.4 g. Additional exams hypercholesterolemia, severe anemia, normal albumin. Testing...
There have been few studies to evaluate the monitoring of plasmatic concentrations vancomycin in septic patients and their association with acute kidney injury (AKI) death. This study aimed prevalence adequate, subtherapeutic, toxic serum hospitalized associate adequacy therapeutic clinical outcomes.This was a cohort-unicentric that evaluated aged >18 years using admitted surgical wards Brazilian university center from August 2016 July 2017 daily uninterrupted way. We excluded AKI prior...
The impact of serum concentrations vancomycin is a controversial topic.182 critically ill patients were evaluated using and 63 included in the study. AKI occurred 44.4% on sixth day use. Vancomycin higher than 17.53 mg/L between second fourth days use was predictor AKI, preceding diagnosis for at least two days, with an area under curve 0.806 (IC 95% 0.624-0.987, p = 0.011). Altogether, 46.03% died, Cox analysis, associated factors age, estimated GFR, CPR, days.The current 2020 guidelines...
In the 1970s, acute peritoneal dialysis (PD) was widely accepted for treatment of kidney injury (AKI), but this practice has declined in favor extracorporeal therapies, mainly developed world. The lack familiarity with use PD critically ill patients also led to a even among those receiving maintenance PD. Renewed interest AKI therapy emerged due its increasing low- and middle-income countries lower cost minimal infrastructural requirements. high-income countries, coronavirus disease 2019...
This study aimed to evaluate the reduction in vancomycin through intermittent haemodialysis (IHD) and prolonged (PHD) acute kidney injury (AKI) patients with sepsis identify variables associated subtherapeutic concentrations. A prospective was performed admitted at an intensive care unit (ICU) of a Brazilian hospital. Blood samples were collected start dialytic therapy, after 2 4 h treatment end therapy determine serum concentration thus perform pharmacokinetic evaluation PK/PD modelling....
Vancomycin pharmacokinetic data in patients with acute kidney injury (AKI) on high-volume peritoneal dialysis (HVPD) are lacking. The aims were to study the pharmacokinetics of i.v. vancomycin AKI treated by HVPD who received an dose (15-20 mg/kg), determine removal, and establish dosing evaluation target attainment achievement for empirical treatment HVPD.Vancomycin was administered 1 hour before start. Samples all dialysate collected a 24-hour period. Blood samples after 1, 2, 4, 24 hours...
Introduction Elderly patients with COVID-19 are at a higher risk of severity and death as not only several comorbidities but also aging itself has been considered relevant factor. Acute kidney injury (AKI), one the worst complications SARS-CoV-2 infection, is associated worse outcomes. Studies on AKI in Latin-American older age remain scarce. Objectives To determine incidence factors its development, well to compare outcome elderly or without infection Methods This retrospective cohort study...
Treatment for severe acute kidney injury (AKI) typically involves the use of replacement therapy (AKRT) to prevent or reverse complications.We aimed determine prevalence successful discontinuation AKRT and its predictive factors. A retrospective cohort study was performed with 316 patients hospitalized at a public Brazilian university hospital between January 2011 June 2020.Success discharge were achieved most (85% 74%, respectively). Multivariable logistic regression analysis showed that...
This study aimed to explore the role of peritoneal dialysis (PD) in acute-on-chronic liver disease (ACLD) relation metabolic and fluid control outcome. Fifty-three patients were treated by PD (prescribed Kt/V = 0.40/session), with a flexible catheter, tidal modality, using cycler lactate as buffer. The mean age was 64.8 ± 13.4 years, model end stage (MELD) 31 6, 58.5% intensive care unit, needed intravenous inotropic agents including terlipressin, 69.5% on mechanical ventilation, alcoholic...
In the different waves of pandemic caused by SARS-CoV-2 virus, elderly continued to be affected with more severe disease cases and possible progression death. Thus, study sought compare incidence AKI in during first second wave Brazil risk factors associated its development
It is acknowledged that Acute Kidney Injury (AKI) multifactorial in COVID-19, as the most relevant factors for its development are cytokine storm, metabolic stress, medication use, rhabdomyolysis, renal viral tropism, and multiple organ dysfunction. However, little known about impact of AKI's pathophysiology on clinical outcome. Our aim to identify pathophysiological mechanisms AKI patients affected by COVID-19 associate them with death.
Drug-Induced Acute Kidney Injury (DIAKI) can be classified in type A reactions, which the mechanism of aggression is explained by drug pharmacology (time use and dose) B when nephrotoxicity not predictable depends on pharmacogenetics corresponds to Interstitial Nephritis (AIN), crystalline nephropathy tubular diseases (Bartterlike or Gitelman-like). This study aimed determine incidence DIAKI, associated drugs, its phenotypes main prognostic factors.
Introduction: COVID-19, caused by the SARS-CoV-2 virus, has been associated with oligosymptomatic cases or severe acute respiratory syndrome, multiple organ failure and death. One of most significant events for clinical outcomes is Acute Kidney Injury (AKI). It known that AKI in COVID-19 multifactorial, main mechanisms are cytokine storm, metabolic stress, use nephrotoxic drugs, rhabdomyolysis, viral tropism to kidney tissues, failure. However, little about impact presentation...
Magalhães et al. demonstrated that the incidence of acute kidney injury was high in hospitalized patients with COVID-19 and second wave associated greater severity; however, mortality rates were similar between two periods. This may reflect both effectiveness vaccines constant learning frontline professionals gained throughout pandemic to provide support their patients.