A5073155116- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Cardiac Arrest and Resuscitation
- Poisoning and overdose treatments
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Central Venous Catheters and Hemodialysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Electrolyte and hormonal disorders
- Clinical Nutrition and Gastroenterology
- Public Health in Brazil
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Hemodynamic Monitoring and Therapy
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Climate Change and Health Impacts
- Nutrition and Health in Aging
- Clostridium difficile and Clostridium perfringens research
- Renal Diseases and Glomerulopathies
Universidade Estadual Paulista (Unesp)
2016-2025
Universidade de São Paulo
2009-2024
Medecell (Brazil)
2017-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2001-2024
Hospital São Paulo
2017
Hospital Terrassa
2014
Changi General Hospital
2014
Universidade Estadual de Campinas (UNICAMP)
2014
University Hospital Leipzig
2014
Leipzig University
2014
BACKGROUND AND PURPOSE Strategies designed to enhance cerebral cAMP have been proposed as symptomatic treatments counteract cognitive deficits. However, pharmacological therapies aimed at reducing PDE4, the main class of catabolizing enzymes in brain, produce severe emetic side effects. We recently synthesized a 3-cyclopentyloxy-4-methoxybenzaldehyde derivative, structurally related rolipram, and endowed with selective PDE4D inhibitory activity. The aim present study was investigate effect...
Summary Background and objectives Peritoneal dialysis is still used for AKI in developing countries despite concerns about its limitations. The objective of this study was to explore the role high-volume peritoneal patients relation metabolic fluid control, outcome, risk factors associated with death. Design, setting, participants, & measurements A prospective performed on 204 who were assigned (prescribed Kt/V=0.60/session) by flexible catheter cycler; 150 (80.2%) included final...
Peritoneal dialysis (PD) is still widely used for acute renal failure (ARF) in developing countries despite concerns about its inadequacy. Continuous PD has been evaluated ARF by analyzing the resolution of metabolic abnormality and normalization plasma pH, bicarbonate, potassium.A prospective study was performed on 30 patients who were assigned to high-dose continuous (Kt/V = 0.65 per session) via a flexible catheter (Tenckhoff) automated with cycler. Fluid removal, pH control, protein...
Patients who develop acute kidney injury (AKI) in the intensive care unit (ICU) have extremely high rates of mortality and morbidity. The objectives this study were to compare clinical laboratory characteristics AKI patients evaluated not by nephrologists ICU generate hypothesis relationship between timing nephrology consultation outcome.We explored associations among presence with stay in-ICU 148 at a Brazilian teaching hospital from July 2008 May 2010. Multivariable logistic regression was...
Renal involvement is frequent in COVID-19 (4-37%). This study evaluated the incidence and risk factors of acute kidney injury (AKI) hospitalized patients with COVID-19. Methodology: represents a prospective cohort public tertiary university hospital São Paulo, Brazil, during first 90 days pandemic, followed up until clinical outcome (discharge or death). Results: There were 101 COVID-19, which 51.9% admitted to intensive care unit (ICU). The overall AKI was 50%; 36.8% had hematuria...
Acute kidney injury (AKI) has increasingly been recognized as an important public health issue due to its rising frequency, associations with early and late adverse outcomes economic burden. Given the importance of determining available resources address this serious issue, AKI Committee SLANH conducted a survey obtain information about infrastructure, human equipment devoted treatment in Latin America A total 246 units from 14 countries participated survey, majority them pertaining...
Peritoneal dialysis (PD) should be considered a suitable method of renal replacement therapy in acute kidney injury (AKI) patients. This study is the largest cohort providing patient characteristics, clinical practice, patterns and their relationship to outcomes developing country. Its objective was describe main determinants technique survival, including trends over time PD treatment AKI Brazilian prospective which all adult patients on were studied from January/2004 January/2014. For...
The definition of adequate dialysis in acute renal failure (ARF) is complex and involves the time referral to dialysis, dose, dialytic method. Nephrologist experience with a specific procedure availability different modalities play an important role these choices. There no consensus literature on best method or ideal dose ARF.Peritoneal (PD) used less ARF patients, being replaced by continuous venovenous therapies. However, it should not be discarded as worthless therapeutic option for...
Intermittent hemodialysis (IHD) and continuous renal replacement therapies (CRRT) are used as Acute Kidney Injury (AKI) therapy have certain advantages disadvantages. Extended daily dialysis (EDD) has emerged an alternative to CRRT in the management of hemodynamically unstable AKI patients, mainly developed countries. Objectives We hypothesized that EDD is a safe option for treatment aimed describe metabolic fluid control patients undergoing identify complications risk factors associated...
In some parts of the world, peritoneal dialysis is widely used for renal replacement therapy (RRT) in acute kidney injury (AKI), despite concerns about its inadequacy. It has been replaced recent years by hemodialysis and, most recently, continuous venovenous therapies. We performed a prospective study to determine effect (CPD), as compared with daily (dHD), on survival among patients AKI.A total 120 tubular necrosis (ATN) were assigned receive CPD or dHD tertiary-care university hospital....
Este trabalho tem como objetivo avaliar a evolução de pacientes com lesão renal aguda (LRA) por Necrose Tubular Aguda internados no Hospital das Clínicas da Faculdade Medicina Botucatu - UNESP. Trata-se estudo coorte retrospectivo, qual foram avaliados 477 maiores 18 anos, período janeiro 2001 dezembro 2008. LRA foi definida acordo os valores crea sérica, conforme proposto pelo Acute Kidney Injury Network (AKIN). A média idade população estudada 65,5 ± 16,2 predomínio homens (62%) e > 60...
OBJECTIVE:The objective of this study was to perform a nutritional assessment acute kidney injury patients and identify the relationship between markers outcomes.METHOD: This prospective observational study.Patients who were hospitalized at Hospital Botucatu School Medicine evaluated January 2009 December 2011.We total 133 with clinical diagnosis presentation suggestive tubular necrosis.We explored associations clinical, laboratory inhospital mortality.Multivariable logistic regression used...
Abstract P rolonged intermittent renal replacement therapy ( PIRRT ) has emerged as an alternative to continuous in the management of acute kidney injury AKI patients. This trial aimed compare dialysis complications occurring during different durations sessions critically ill We included patients older than 18 years with associated sepsis admitted intensive care unit and using noradrenaline doses ranging from 0.3 0.7 µg/kg/min. Patients were divided into two groups randomly: G 1, 6‐h...
Peritoneal dialysis (PD) is a simple, safe, cheap, and efficient renal replacement therapy method. It can correct metabolic disorders fluid overload in acute kidney injury (AKI) patients both out of the intensive care unit. Use PD AKI enhanced by placement Tenckhoff catheter, which be safely accomplished at bedside. Some modalities, such as high-volume continuous-flow PD, provide doses efficiency comparable to extracorporeal blood purification methods. particularly suitable for neonates,...