A5018117774- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Developmental Biology and Gene Regulation
- Cancer Research and Treatments
- Circular RNAs in diseases
- Iron Metabolism and Disorders
- Single-cell and spatial transcriptomics
- Trace Elements in Health
- T-cell and B-cell Immunology
- Signaling Pathways in Disease
- Barrier Structure and Function Studies
- Mitochondrial Function and Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Lipid Membrane Structure and Behavior
- Autophagy in Disease and Therapy
- Photoacoustic and Ultrasonic Imaging
- Cancer Cells and Metastasis
Aarhus University
2024-2025
Aalborg University
2014-2024
Technical University of Denmark
2021
Faculty (United Kingdom)
2015
Low density lipoprotein receptor-related protein 2 (LRP2) is a 600 kilodalton multi-ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and select absorptive epithelial cells the adult. In cancers, LRP2 expression associated with differentiated tumor state better prognosis. previous work, we found that while not benign naevi, it frequently acquired melanoma. However, molecular drivers of melanoma characteristics...
Macrophages infiltrate all human tissues where they play key roles in innate immunity, homeostasis, and tissue function. However, extensive clinical experimental evidence indicates that macrophages also contribute significantly to the progression of several diseases such as cancer, cardiometabolic disorders, inflammatory neurodegenerative conditions. Advances single-cell omics have revealed diverse macrophage populations both healthy diseased tissues. studying their functions is challenging...
Precise methods for quantifying drug accumulation in brain tissue are currently very limited, challenging the development of new therapeutics disorders. Transcardial perfusion is instrumental removing intravascular fraction an injected compound, thereby allowing ex vivo assessment extravasation into brain. However, pathological remodeling microenvironment can affect efficiency transcardial perfusion, which has been largely overlooked. We show that, contrast to healthy vasculature, cannot...
Abstract Background Chronic neurodegenerative diseases are characterized by substantial neuroinflammation with accumulation of macrophages, reactive microglia, and astrocytes. Impairment the brain vasculature is also commonly seen in chronic neurodegeneration causal links warranting further investigation. Methods To address effects on regional vasculature, we performed a unilateral injection glutamate receptor agonist ibotenic acid into striatum adult rats, which caused excitotoxicity...
Chronic neurodegenerative diseases are characterized by substantial inflammation with putative impairment of the brain vasculature also commonly observed. To address effects chronic neurodegeneration on regional under experimentally controlled circumstances, glutamate receptor agonist ibotenic acid was injected into striatum adult rats, which causes excitotoxicity in substantia nigra pars reticulata (SNpr) due to imbalance between inhibitory inputs from and excitatory signals subthalamic...
Abstract Cripto‐1 is a protein expressed during embryonal development and has been linked to several malignant processes in cancer. Since the discovery of cripto‐1 late 1980s, it become subject biomarker investigation types cancer which many cases relies on immunolocalization using antibodies. Investigating expression localization primary glioblastoma cells, we discovered nonspecific binding antibody extracellular matrix Geltrex. A panel four antibodies was investigated with respect their...