A5102821565- Chronic Kidney Disease and Diabetes
- Blood properties and coagulation
- Birth, Development, and Health
- Global Public Health Policies and Epidemiology
- Signaling Pathways in Disease
- Genetic and Kidney Cyst Diseases
- Sex and Gender in Healthcare
- Dialysis and Renal Disease Management
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Systemic Sclerosis and Related Diseases
- Renal and related cancers
- Platelet Disorders and Treatments
- Electrolyte and hormonal disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal cell carcinoma treatment
- Occupational and environmental lung diseases
- Pancreatic and Hepatic Oncology Research
Aarhus University
2023-2025
Introduction: The open conformation of the enzyme transglutaminase 2 (TG2) contributes to kidney fibrosis through transamidase activity by cross-linking extracellular matrix fibres and releasing transforming growth factor β1 (TGFβ1), a key driver fibrogenesis. We investigated antifibrotic potential TG2 inhibition downstream TGFβ1 using two inhibitors, LDN27219 Z-DON, which modulate into closed state, respectively. Methods: inhibitors were studied in human precision-cut slices (PCKS) cell...
The open conformation of the enzyme transglutaminase 2 (TG2) contributes to kidney fibrosis through transamidase activity by cross-linking extracellular matrix fibres and releasing transforming growth factor β1 (TGFβ1), a key driver fibrogenesis. We investigated antifibrotic potential TG2 inhibition downstream TGFβ1 using two inhibitors, LDN27219 Z-DON, which modulate into closed state, respectively. inhibitors were studied in human precision-cut slices (PCKS) cell cultures primary renal...
Low density lipoprotein receptor-related protein 2 (LRP2) is a 600 kilodalton multi-ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and select absorptive epithelial cells the adult. In cancers, LRP2 expression associated with differentiated tumor state better prognosis. previous work, we found that while not benign naevi, it frequently acquired melanoma. However, molecular drivers of melanoma characteristics...
More than 80% of human cancers originate in epithelial tissues. Loss cell characteristics are hallmarks tumor development. Receptor-mediated endocytosis is a key function absorptive cells with importance for cellular and organismal homeostasis. LRP2 (megalin) the largest known endocytic membrane receptor essential various ligands specialized epithelia, including proximal tubules kidney, thyroid gland, breast glandular epithelium. However, role regulation that arise from these tissues has not...