A5105923429- Amino Acid Enzymes and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Angiogenesis and VEGF in Cancer
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Estrogen and related hormone effects
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Radiopharmaceutical Chemistry and Applications
- Drug Transport and Resistance Mechanisms
- Impact of Education Environments
- Peptidase Inhibition and Analysis
- Click Chemistry and Applications
- Phagocytosis and Immune Regulation
- Advanced NMR Techniques and Applications
- Digital Storytelling and Education
- Autophagy in Disease and Therapy
- Teacher Education and Leadership Studies
- Cancer-related Molecular Pathways
University of Aberdeen
1982-2022
Queen's University Belfast
2021
Cancer Research UK
2001-2020
Molecular Discovery (United Kingdom)
2017
Queen Mary University of London
2008
St Bartholomew's Hospital
1999-2004
The Honourable Society of Lincoln's Inn
1993-1998
Roundabout receptors are molecular guidance molecules that function by interaction with Slit proteins to regulate axon guidance, neuronal migration, and leukocyte chemotaxis. We recently isolated a novel roundabout gene, called Robo4, which is restricted in expression the endothelium, notably areas of angiogenesis. The aim this study was use soluble extracellular domain Robo4 as probe angiogenesis endothelial biology. Thus, receptor (Robo4Fc) showed diverse vivo vitro activities including 1)...
The mda-7 gene (melanoma differentiation associated gene-7) is a novel tumor suppressor gene. anti-proliferative activity of MDA-7 has been previously reported. In this report, we analyze the anti-tumor efficacy Ad-mda7 in broad spectrum cancer lines.Ad-mda7-transduced or normal cell lines were assayed for proliferation (tritiated thymidine incorporation assay, Alamar blue and trypan-blue exclusion assay), apoptosis (TUNEL, Annexin V staining visualized by fluorescent microscopy FACs...
The dual energy requirement (protonmotive force and ATP) of the Escherichia coli Trk potassium transport system has been investigated. Using inhibitors unc mutants we show that is not an ATPase but may be regulated by ATP. Possible mechanisms coupling to are discussed.
Abstract Calcium/calmodulin-dependent protein kinase 2 (CaMKK2) regulates cell and whole-body metabolism supports tumorigenesis. The cellular impacts of perturbing CAMKK2 expression are, however, not yet fully characterised. By knocking down levels, we have identified a number significant subcellular changes indicative perturbations in vesicle trafficking within the endomembrane compartment. To determine how they might contribute to effects on proliferation, used proteomics identify Gemin4...
Conference Article| June 01 1984 Properties and physiology of energy-coupled mutants Escherichia coli IAN R. BOOTH; BOOTH 1Department Microbiology, University Aberdeen, Marischal College, Aberdeen AB9 1AS, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROHAN G. KROLL; KROLL MORNA J. FINDLAY; FINDLAY LORNA M. D. STEWART; STEWART GEOFFREY C. ROWLAND Biochem Soc Trans (1984) 12 (3): 409–411. https://doi.org/10.1042/bst0120409 Views Icon Article contents...
In response to the Covid-19 pandemic, virtual observations were introduced assess studentteachers, in a Scottish Initial Teacher Education (ITE) department. This research criticallyreflects on usage of these as they deployed large scale tomeant emergency requirements teacher education during pandemic. Using GroundedTheory qualitative frame (Merriam & Tisdell, 2016), this employs Clarke’s (2005)situational analysis provide insights into how effective are theassessment teaching practicum....
Conference Article| June 01 1984 Energy coupling to K+ transport via the Trk system of Escherichia coli LORNA M. D. STEWART; STEWART *Department Microbiology, University Aberdeen, Marischal College, Aberdeen AB9 1AS, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar EVERT P. BAKKER; BAKKER †Fachbereich Biologie/Chemie-Mikrobiologie Postfach 4469, D-4500 Osnabruck, Federal Republic Germany IAN R. BOOTH Author and article information Publisher: Portland...
Abstract CD73 is a membrane-bound nucleotidase receptor which frequently overexpressed in the tumour microenvironment and can be found on both immune cell types. Its function to catalyse conversion of adenosine monophosphate (AMP) phosphate it has been proposed as therapeutic target cancer due adenosines role suppression. Using multiple approaches, series novel antibodies have characterised for their potential benchmarked against agents currently undergoing clinical evaluation Inhibition...
Conference Article| December 01 1982 Proline transport in Escherichia coli LORNA M. D. STEWART; STEWART 1Department of Microbiology, University Aberdeen, Marischal College, Aberdeen AB9 1AS, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar IAN R. BOOTH 2Department Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print 0300-5127 © Biochemical Society1982 Biochem Soc Trans (1982) 10 (6): 467–468....