A5022555703- Carcinogens and Genotoxicity Assessment
- Plant Pathogens and Resistance
- Potato Plant Research
- Metabolomics and Mass Spectrometry Studies
- Biological and pharmacological studies of plants
- Nephrotoxicity and Medicinal Plants
- Natural product bioactivities and synthesis
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Bioactive Compounds and Antitumor Agents
- Antioxidant Activity and Oxidative Stress
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Neurological Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Ginseng Biological Effects and Applications
- Dye analysis and toxicity
- Pesticide Residue Analysis and Safety
- Bladder and Urothelial Cancer Treatments
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Heavy Metals in Plants
China Medical University
2014-2023
Asia University
2017
Changhua Christian Hospital
2012
China Medical University Hospital
2006
Chang Gung University
2001
University of North Carolina at Chapel Hill
1994-1998
New York State Department of Health
1998
Chrysophanol (1,8‐dihydroxy‐3‐methylanthraquinone) is one of the anthraquinone compounds, and it has been shown to induce cell death in different types cancer cells. The effects chrysophanol on human lung have not well studied. purpose this study examine chrysophanol‐induced cytotoxic also investigate such influences that involved apoptosis or necrosis A549 cells vitro . Our results indicated decreased viable a dose‐ time‐dependent manner. promoted release reactive oxygen species (ROS) Ca 2+...
1,3-Butadiene (BD) is a high volume industrial chemical which known as multi-site rodent carcinogen and classified probable human carcinogen. Covalent interactions of the reactive epoxy metabolites BD with DNA lead to formation adducts may cause mutations tumor formation. In present work, liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) was employed for analyses BD-induced in vitro vivo. Selected reaction monitoring (SRM) using fragmentation [M+H]+ ions...
Zuo-Jin-Wan (ZJW), a two-herb formula consisting of Coptis chinensis (CC) and Evodia rutaecarpa (ER), is commonly used in traditional Chinese medicine for the treatment cancers. However, efficacies mechanisms ZJW its alkaloid components on cancers are still unclear.Here we investigated anti-cancer effects ZJW, CC, ER, berberine, evodiamine cells intrahepatic xenograft mice.Treatment HepG2 with significantly displayed cytotoxic dose- time-dependent manner. Hierarchical cluster analysis gene...
Gastrodia elata Bl. (GE) is a traditional Chinese herb that commonly used in communities to treat convulsive disorders such as epilepsy. The purpose of the present study was determine anticonvulsive and free radical activities GE rats. In vitro studies were conducted by using brain tissue from 6 male Sprague-Dawley (SD) rats treated with 120 μg/ml kainic acid (KA), or without addition various concentrations GE. vivo total 30 SD divided into 5 groups which follows: 1) normal group received an...
Proliferation of intimal vascular smooth muscle cells is an important component in the development atherosclerosis. Ellagic acid a phenolic compound present fruits (raspberries, blueberries, strawberries) and walnuts. The study investigated effect ellagic on oxidised LDL (ox-LDL)-induced proliferation rat aortic (RASMC). found that significantly inhibited ox-LDL-induced RASMC phosphorylation extracellular signal-regulated kinase (ERK) 1/2.Furthermore, also blocked (inducible) cell-cycle...
The authors' previous study has shown that water extract of Hedyotis diffusa Willd (HDW) promoted immune response and exhibited anti-leukemic activity in BALB/c leukemic mice vivo. In this study, the anti-proliferation effects ethanol H. (EEHDW) on lung cancer cell lines (A549, H1355, LLC), leukemia (HL-60, WEHI-3), a mouse melanoma line (B16F10) vitro were investigated. results demonstrated EEHDW suppressed proliferation A549, HL-60, WEHI-3, B16F10 cells as well reduced viability...
Radix Paeoniae Rubra (RPR) is the dried root of Paeonia lactiflora Pallas and veitchii Lynch, a herbal medicine that widely used in traditional Chinese for treatment blood‑heat blood‑stasis syndrome, similarly to Cortex Moutan. The present study identified same three components RPR Moutan extracts. In addition, it has been reported an anti‑cancer effect. Bladder cancer seventh most common type worldwide. Due high recurrence rate, identifying novel drugs bladder therapy essential. study,...
Abstract The Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) has systematically documented suspected adverse events from drug reaction (ADR) reports 1998 (prior to its formal establishment in 2001) and evaluates safety profiles of herbal medicines. This article describes findings 2079 ADR filed between 2016: 941 involved single herbs 87 folk herbals; 842 were generated clinical trials, while 209 involving foods, health dietary supplement foods cuisine grouped as...
Abstract BACKGROUND Serious concerns surround the potential risks resulting from inhalation exposure to pesticides amongst agricultural workers when mixing and applying these compounds. In Eswatini (formerly known as Swaziland), Southern Africa, are widely used improve yield quality of sugar cane production, largest contributor country's economy. We assessed applicators' exposures multiple spraying sources four commonly herbicides in Eswatini. RESULTS Analysis 76 personal air samples by...