A5065553292- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Ubiquitin and proteasome pathways
- Pituitary Gland Disorders and Treatments
- Cancer Genomics and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Moyamoya disease diagnosis and treatment
- Neurological Disease Mechanisms and Treatments
- Cancer-related Molecular Pathways
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Head and Neck Surgical Oncology
- Angiogenesis and VEGF in Cancer
- Flavonoids in Medical Research
- Electrospun Nanofibers in Biomedical Applications
- Saffron Plant Research Studies
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Spinal Dysraphism and Malformations
Taichung Veterans General Hospital
2013-2024
National Chung Hsing University
2013-2024
Hungkuang University
2013-2024
Zhengzhou University of Light Industry
2024
National Taipei University
2013-2023
National Defense Medical Center
2020
Institute of Biomedical Science
2019-2020
National Central University
1997-2019
National Yang Ming Chiao Tung University
2013-2019
Central Taiwan University of Science and Technology
2019
Although suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been used in clinical trials for cancer therapies, its pharmacological effects occur through poorly understood mechanism. Here, we report that SAHA specifically triggers autophagy and reduces cell viability via promotion of apoptosis the late phase glioblastoma stem cells (GSCs). Using line cultured from biopsy, investigated properties GSCs under treatment vitro. In vivo xenograft assays revealed...
Abstract This study utilized Next-Generation Sequencing (NGS) to explore genetic determinants of survival duration in Glioblastoma Multiforme (GBM) patients. We categorized 30 primary GBM patients into two groups based on their periods: extended (over years, N = 17) and abbreviated (under 13). For identifying pathogenic or likely variants, we leveraged the ClinVar database. The cohort, aged 23 66 (median: 53), included 17 Group A (survival >2 10 males, 7 females), 13 B <2 8 5 with a...
Luteolin (3',4',5,7-tetrahydroxyflavone) is a common flavonoid in many types of plants and has several beneficial biological effects, including anti-inflammation, anti-oxidant, anti-cancer properties. However, the detail mechanisms luteolin suppressing tumor invasion metastasis are poorly understood. Here, we investigated effects on glioblastoma cell migration activity. Under non-cytotoxic doses (15 30 μM), exhibited an inhibitory effect U-87 MG T98G cells. Additionally, filopodia assembly...
Traditional Chinese medicine (TCM) has been used for thousands of years. Most herbal formulae consist several components and have to treat various diseases. However, the mechanisms most relationship between their remain be elucidated. Here we analyzed putative mechanism San-Huang-Xie-Xin-Tang (SHXXT) defined SHXXT its by microarray technique. HepG2 cells were treated with or gene expression profiles DNA microarray. Gene set enrichment analysis indicated that displayed a unique...
Glioblastoma is one of the most angiogenic malignancy, neoplastic vessels which are likely to arise by angiogenesis and vasculogenesis. An alternative mechanism tumor vasculature described, termed vasculogenic mimicry, highly aggressive cells can form vessel-like structures themselves, virtue their high cellular plasticity. Evidence suggests that cancer stem acquire a multi-potent plastic phenotype show potential. In this study, we report glioblastoma stem-like (GSCs) mimicry in xenografts...
ATPase-family, AAA domain containing 3A (ATAD3A) is located on human chromosome 1p36.33, and high endogenous expression may associate with radio- chemosensitivity. This study was conducted to investigate the significance of ATAD3A in glioblastoma multiforme (GBM).Clinical assessed by immunohistochemistry 67 GBM specimens, prognostic value 32 patients statistically. To vitro phenotypic effects ATAD3A, cell viability measured using a clonogenic survival assay under either knockdown or ectopic...
Recent studies have shown the potential of artificially synthesized conduits in repair peripheral nerve injury. Natural biopolymers received much attention because their biocompatibility. To investigate effects novel electrospun absorbable poly(ε-caprolactone)/type I collagen nanofiber (biopolymer conduits) on injury, we bridged 10-mm-long sciatic defects with biopolymer conduits, poly(ε-caprolactone) or silicone Sprague-Dawley rats. Rat neurologica1 function was weekly evaluated using index...
The supraorbital keyhole approach is most frequently used in treatment for lesions within the anterior cranial base. However, it has some drawbacks, including cosmetically poor appearance of scar, forehead deformity, and difficulty dealing with kinds middle cerebral artery (MCA) internal carotid (ICA) aneurysms. Therefore, we have developed a small pterion an alternative access to treat circulation An oblique skin incision about 3-5 cm length was made just from 1.0 superficial temporal at...
Pulmonary inflammation is a characteristic of many lung diseases. Increased levels inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory cytokines, such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) IL-8, have been correlated with inflammation. In this study, we used lipopolysaccharide (LPS) to induce iNOS, COX-2, cytokines (TNF-α, IL-1β, IL-8) productions in human epithelial cells (A-549). Leaf Eriobotrya japonica (Pi-Pa-Ye, PPY), traditional...
Stroke represents one of the leading causes death and disability in humans, but despite intense research, only a few options exist for treatment stroke-related infarction brain tissue. Thus far, experimental strokes, cell therapy appears to partly reverse some behavioral deficits. However, mechanisms action remain uncertain as most studies reveal little, if any, evidence neuronal replacement observed improvements. This present study was performed test rodent fetus forebrain derived neural...
Neural progenitors cells are capable of promoting neurogenesis after ischemic stroke in the adult mammalian brain; however function these and their fate is still not clear. Therefore purpose this study investigated relationship between neural reactive astrocytes middle cerebral artery occlusion (MCAO). Brain infarction was induced by a right male Wistar rats. The progenitor surrounding immunochemical staining for nestin, vimentin glial fibrillary acidic protein (GFAP) positive at several...
On-line monitoring of ORP has been proved to be a practical and useful technique for process control wastewater treatment systems. This paper presents the feasibility using on-line system on laboratory scale single tank continuous-flow activated sludge batch reactor, which is capable removing carbon, nitrogen phosphorus pollutants. Two strategies, fixed-time real-time, are applied control. Results obtained from study indicate that variations profile can accurately represent dynamic...
Civilian gunshot wounds to the brain are relatively rare, and a much-neglected subject in Taiwan. We present our experience with 16 patients who sustained brain, then identify factors determining respective outcomes.From 1988-2002, data from civilian were treated at Taichung Veterans General Hospital, retrospectively reviewed. Historical information, clinical manifestations, imaging findings described. Based on Glasgow Outcome Score (GOS), divided into poor-outcome group (GOS, 1-2)...
Aim: Arsenic trioxide (As<sub>2</sub>O<sub>3</sub>), known as pi-shuang and the most toxic compound in traditional Chinese medicine, has been used an antitumor agent for thousands of years. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural phenol that significant anti-bacterial, anti-fungaI antiaging activities. Our study aimed to examine combined anticancer effects As<sub>2</sub>O<sub>3</sub> resveratrol against human neuroblastoma SK-N-SH cells, elucidate underlying intracellular...
In the present study, various concentrations of AuNP (1.25, 2.5, 5, 10 ppm) were prepared to investigate biocompatibility, biological performances and cell uptake efficiency via Wharton’s jelly mesenchymal stem cells rat model. The pure AuNP, combined with Col (AuNP-Col) FITC conjugated AuNP-Col (AuNP-Col-FITC) characterized by Ultraviolet–visible spectroscopy (UV-Vis), Fourier-transform infrared (FTIR) Dynamic Light Scattering (DLS) assays. For in vitro examinations, we explored whether...
Primary brain tumors associated with intracranial aneurysm are rare. A combination of glioblastoma multiforme (GBM) cerebral is even more We present a 67-year-old female, who suffered from progressive weakness the right limbs and dysphasia for 2 days. She was referred another hospital impression having tumor. The non-enhanced computed tomographic (CT) scan showed mass lesion over left parietal region, tiny relatively high density suprasellar region. After admission, carotid angiogram...