A5012344394- Blood Pressure and Hypertension Studies
- Bariatric Surgery and Outcomes
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Coronary Interventions and Diagnostics
- Chronic Disease Management Strategies
- Electronic Health Records Systems
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Healthcare Systems and Technology
- Dementia and Cognitive Impairment Research
- Machine Learning in Healthcare
- Antiplatelet Therapy and Cardiovascular Diseases
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Mobile Health and mHealth Applications
- Cardiac pacing and defibrillation studies
- Global Cancer Incidence and Screening
- Chronic Kidney Disease and Diabetes
- Childhood Cancer Survivors' Quality of Life
- Healthcare Policy and Management
- Cardiomyopathy and Myosin Studies
- Pharmacological Effects and Toxicity Studies
- Colorectal Cancer Treatments and Studies
- Smoking Behavior and Cessation
Kaiser Permanente
2015-2024
Parker Hannifin (United States)
2020
University of Cincinnati Medical Center
2019
Cincinnati Children's Hospital Medical Center
2019
University of Cincinnati
2019
University of Colorado Denver
2010-2012
HealthPartners
2010-2012
Denver Health Medical Center
2012
Patient-Centered Outcomes Research Institute
2012
Denver VA Medical Center
2010-2012
Background— Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, incidence and prognosis this condition are largely unknown. Methods Results— This retrospective cohort study in 2 integrated health plans included patients with incident hypertension whom treatment was begun between 2002 2006. Patients were followed up for development based on AHA criteria uncontrolled blood pressure despite use ≥3 antihypertensive...
To determine whether bariatric surgery is associated with a lower risk of cancer.Obesity strongly many types cancer. Few studies have examined the relationship between and cancer risk.We conducted retrospective cohort study patients undergoing 2005 2012 follow-up through 2014 using data from large integrated health insurance care delivery systems 5 sites. The included 22,198 subjects who had 66,427 nonsurgical matched on sex, age, site, body mass index, Elixhauser comorbidity index....
<h3>Context</h3>Prior studies suggest that providing patients with online access to health records and e-mail communication physicians may substitute for traditional care services.<h3>Objective</h3>To assess utilization by both users nonusers of before after initiation MyHealthManager (MHM), a patient system.<h3>Design, Setting, Participants</h3>Retrospective cohort study the use services members (≥18 years old) who were continuously enrolled at least 24 months during period March 2005...
Depression among pregnant women is a prevalent public health problem associated with poor maternal and offspring development. Behavioral activation (BA) scalable intervention aligned women's preference for nonpharmacological depression care. This the first test of effectiveness BA women, which aimed to evaluate as compared treatment usual (TAU).
Objective: This retrospective cohort study examined whether bariatric surgery is associated with reduced risk of breast cancer among pre- and postmenopausal women. Background: Obesity increased cancer, but the impact weight loss on has been difficult to quantify. Methods: The included obese (body mass index ≥35 kg/m 2 ) patients enrolled in an integrated health care delivery system between 2005 2012 (with follow-up through 2014). Female ( N = 17,998) were matched body index, age, site,...
Patients with resistant hypertension are at risk for poor outcomes. Medication adherence and intensification improve blood pressure (BP) control; however, little is known about these processes or their association outcomes in hypertension. This retrospective study included patients from 2002 to 2006 incident 2 health systems who developed uncontrolled BP despite ≥3 antihypertensive medications. Patterns of treatment, medication (percentage days covered), treatment (increase class dose) were...
Hypertension is an important cause of chronic kidney disease (CKD). Identifying risk factors for progression to CKD in patients with normal function and hypertension may help target therapies slow or prevent decline function. Our objective was identify development incident estimated GFR (eGFR) hypertensive patients.Cox proportional hazards models were used assess the relationship between (defined as eGFR <60 ml/min per 1.73 m(2)) potential from a registry patients.Of 43,305 meeting inclusion...
Objective The goal of this study was to determine whether the reduction in cancer risk after bariatric surgery is due weight loss. Methods A retrospective matched cohort patients undergoing conducted using data from a large integrated health insurance and care delivery system with five sites four states. included 18,355 subjects 40,524 nonsurgical on age, sex, BMI, site, Elixhauser comorbidity index. Multivariable Cox proportional hazards models examined relationship between loss at 1 year...
Breast cancer survivors are at increased risk for developing second primary cancers compared with the general population. Little is known about whether body mass index (BMI) increases this risk. We examined association between BMI and among women incident invasive breast cancer.This retrospective cohort included 6481 patients from Kaiser Permanente Colorado Washington of whom 822 (12.7%) developed a (mean follow-up was 88.0 months). first extracted medical record. Outcomes included: 1) all...
Adjuvant clopidogrel therapy is essential after drug-eluting stent (DES) implantation. The frequency with which patients delay filling a prescription DES implantation and the association of this adverse outcomes unknown.This was retrospective cohort study discharged from 3 large integrated health care systems. Filling based on pharmacy dispensing data. primary end point all-cause mortality or myocardial infarction (MI). Of 7402 implantation, 16% (n=1210) did not fill day discharge median...
Abstract Background Numerous studies have examined melanoma incidence and survival, but on recurrence are limited. We incidence, recurrence, mortality among members of Kaiser Permanente Colorado (KPCO) between January 1, 2000 December 31, 2015. Methods Age‐adjusted rates were computed to examine trends KPCO aged 21 years older. Cox proportional hazards models used factors associated with mortality. Results Our cohort included 1931 cases invasive melanoma. Incidence increased over time higher...
Abstract Retention in hypertension care, medication adherence, and blood pressure (BP) may have been affected by the COVID‐19 pandemic. In a retrospective cohort study of 64 766 individuals with treated from an integrated health care system, we compared during year pre‐COVID‐19 (March 2019–February 2020) first 2020–February 2021). was defined as receiving clinical BP measurements COVID‐19. Medication adherence measured using prescription refills. Clinical assessed in‐person virtual visits...
Background— Studies suggest that extended clopidogrel use after drug-eluting stent (DES) implantation may decrease the risk of myocardial infarction (MI) and death. Little is known about competing bleeding from in “real world” clinical practice. Methods Results— We studied 7689 patients undergoing enrolled HMO Research Network-Stent Registry between 2004 2007. Patients were analyzed 6-month intervals for occurrence major bleeding, MI, Clopidogrel was determined by pharmacy dispensing data....
Our primary purpose is to understand comorbidities and health outcomes associated with electronic nicotine delivery systems (ENDS) use.Study participants were Kaiser Permanente (KP) members from eight US regions who joined the Research Bank (KPRB) September 2015 through December 2019 completed a questionnaire assessing demographic behavioral factors, including ENDS traditional cigarette use. Medical history obtained records. We used multinomial logistic regression estimate odd ratios (ORs)...
For privacy and practical reasons, it is sometimes necessary to minimize sharing of individual-level information in multisite studies. However, often needed perform more rigorous statistical analysis.To compare empirically 3 analytic methods for studies that only require summary-level analysis have traditionally required access detailed data from each site.We analyzed a 7-site study bariatric surgery outcomes within the Scalable Partnering Network. We compared long-term risk...
IMPORTANCE Laparoscopic Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable banding (AGB) are 2 of the most commonly performed bariatric procedures worldwide.However, few large, multisite studies have directly compared benefits harms these procedures.OBJECTIVE To compare effect RYGB vs AGB on short-and long-term health outcomes.
Although combustible cigarette use is an established risk factor for severe COVID-19 disease, there conflicting evidence the association of electronic with SARS-CoV-2 infection and disease severity.Study participants were from Kaiser Permanente Research Bank (KPRB), a biorepository that includes adult members across United States. Starting in April 2020, surveys sent to KPRB assess impact pandemic. These collected information on self-report COVID-related factors, including smoking history....
Abstract Background As more states legalize cannabis for medical and recreational use, people increasingly use to treat conditions associated symptoms. The prevalence utility of cancer-related symptoms may be clarified by examining among patients with a common cancer diagnosis. We aimed determine the colorectal (CRC) survivors its associations quality life (QoL) symptomatology. Methods A cross-sectional survey patient-reported QoL outcomes behaviors, including was conducted within Patient...
Objective: Hypertension management requires detection (i.e. confirmation of persistently high blood pressure (BP) after an initial elevated measurement) and recognition the condition (evidenced by a formal diagnosis and/or initiation treatment). Our objective was to determine whether disparities exist in BP or treatment) hypertension patients with depression anxiety. Methods: Using data from Cardiovascular Research Network Registry, we assessed time-to-detection comorbid anxiety compared...
Primary prevention implantable cardioverter-defibrillators (ICDs) reduce mortality in selected patients with left ventricular systolic dysfunction by delivering therapies (antitachycardia pacing or shocks) to terminate potentially lethal arrhythmias; inappropriate also occur. We assessed device among adults receiving primary ICDs 7 healthcare systems.