A5051195661- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Neuroendocrine regulation and behavior
- Behavioral and Psychological Studies
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Mindfulness and Compassion Interventions
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Anomalies
- Behavioral Health and Interventions
- Pain Management and Placebo Effect
- Ear Surgery and Otitis Media
- Mind wandering and attention
Laureate Institute for Brain Research
2021-2025
University of Tulsa
2023-2025
McLean Hospital
2017-2024
Harvard University
2017-2024
Imaging Center
2024
Netherlands Metabolomics Centre
2020
Biobanking and BioMolecular resources Research Infrastructure The Netherlands
2020
University of Oxford
2013-2018
Lemuel Shattuck Hospital
2018
Radboud University Nijmegen
1981
Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) is under clinical investigation as a treatment for major depressive disorder. However, mechanisms action are unclear, and there lack neuroimaging evidence, particularly among individuals with affective dysfunction. Furthermore, no causal evidence humans that prefrontal-amygdala circuit functions described in animal models (ie, increasing activity cortical control regions inhibits amygdala response to...
Abstract Approach–Avoidance conflict (AAC) arises from decisions with embedded positive and negative outcomes, such that approaching leads to reward punishment avoiding neither. Despite its importance, the field lacks a mechanistic understanding of which regions are driving avoidance behavior during conflict. In current task, we utilized transcranial magnetic stimulation (TMS) drift-diffusion modeling investigate role one most prominent relevant AAC—the dorsolateral prefrontal cortex...
Adaptive behavior requires balancing approach and avoidance based on the rewarding aversive consequences of actions. Imbalances in this evaluation are thought to characterize mood disorders such as major depressive disorder (MDD). We present a novel application drift diffusion model (DDM) suited quantify how offers reward aversiveness, neural correlates thereof, dynamically integrated form decisions, processes altered MDD. Hierarchical parameter estimation from DDM demonstrated that MDD...
Major Depressive Disorder (MDD) is characterized by increased stress sensitivity. Emerging findings in healthy adults suggest that responses within limbic/striatal-prefrontal regions are moderated sex and unfold over time. Thus, we hypothesized response abnormalities MDD might be affected exposure The Montreal Imaging Stress Task was administered to 124 unmedicated patients with first-episode (76 females) 243 controls (HC; 137 during functional magnetic resonance imaging (fMRI). Based on...
Computational modelling is a promising approach to parse dysfunctional cognitive processes in substance use disorders (SUDs), but it unclear how much these change during the recovery period. We assessed 1-year follow-up data on sample of treatment-seeking individuals with one or more SUDs (alcohol, cannabis, sedatives, stimulants, hallucinogens, and/or opioids; <em>N</em> = 83) that were previously at baseline within prior computational study. Relative healthy controls (HCs; 48),...
Anxiety and depression commonly co-occur, yet the underlying brain behavioral processes are poorly understood. Here we examined hypothesis that individuals with comorbid anxiety would show increased fearful reactivity to an aversive interoceptive perturbation relative depressed-only individuals. One-hundred eighty anxious and/or depressed participants from Tulsa 1000 study completed multi-level or functional magnetic resonance imaging assessments of interoception nociception including...
Objective: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated stress regulation depressive phenotypes. The authors sought to address a critical gap knowledge, namely, how circuitry is functionally affected by GABA current or remitted major disorder (MDD). Methods: Multimodal imaging data were collected from 130 young adults (ages 18–25), of whom 44 had MDD, 42 healthy...
Psychiatric disorders are highly heterogeneous and often co-morbid, posing specific challenges for effective treatment. Recently, computational modeling has emerged as a promising approach characterizing sources of this heterogeneity, which could potentially aid in clinical differentiation. In study, we tested whether mechanisms decision-making under approach-avoidance conflict (AAC) where behavior is expected to have both positive negative outcomes - may utility regard. We first carried out...
Decision-making under approach-avoidance conflict (AAC; e.g., sacrificing quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders. Recently, we used a computational (active inference) model characterize information processing differences during AAC individuals with depression, anxiety and/or substance use Individuals disorders exhibited increased decision uncertainty (DU) and reduced sensitivity unpleasant stimuli. This preregistered study aimed determine...
Abstract Background Preclinical and human studies suggest an association between chronic inflammation the development of depressive behaviors. This is proposed to occur through downstream effects inflammatory cytokines on neuroplasticity, neurogenesis neurotransmitter function, although neural correlates remain poorly understood in humans. Methods In Study 1, structural magnetic resonance imaging serum cytokine data were analyzed from 53 psychiatrically healthy female participants....
Purpose Gamma‐aminobutyric acid (GABA) abnormalities have been implicated in a range of neuropsychiatric disorders. Despite substantial interest probing GABA vivo, human imaging studies relying on magnetic resonance spectroscopy (MRS) generally hindered by technical challenges, including GABA’s relatively low concentration and spectral overlap with other metabolites. Although past shown moderate‐to‐strong test‐retest repeatability reliability within certain brain regions, many these limited...
Background Emerging evidence has highlighted the moderating effect of childhood maltreatment (CM) in shaping neurobiological abnormalities major depressive disorder (MDD). However, whether neural mechanisms underlying stress sensitivity MDD are affected by history CM is unclear. Methods Two hundred and thirteen medication-free female participants were recruited for a functional magnetic resonance imaging study assessing effects psychosocial on responses. The Montreal Imaging Stress Task was...
Substance use disorders (SUDs) represent a major public health risk. Yet, our understanding of the mechanisms that maintain these remains incomplete. In recent computational modeling study, we found initial evidence SUDs are associated with slower learning rates from negative outcomes and less value-sensitive choice (low "action precision"), which could help explain continued substance despite harmful consequences.