A5033707882- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Muscle activation and electromyography studies
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Computational Drug Discovery Methods
- Mast cells and histamine
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Meningioma and schwannoma management
- Balance, Gait, and Falls Prevention
- Neurological disorders and treatments
- Medical Image Segmentation Techniques
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Stress Responses and Cortisol
- Visual Attention and Saliency Detection
- Cardiovascular and exercise physiology
- Advanced Radiotherapy Techniques
Yale University
2021-2024
University of California, San Francisco
2014
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression PD. We evaluated system patients with mild and early PD before after six-month program intense exercise. Using
The automatic patient positioning system and its alignment is critical specified to be less than 0.35 mm for a radiosurgical treatment with the latest robotized Gamma Knife Perfexion (GKPFX). In this study, we developed quantitative QA procedure verify accuracy robustness of such system. particular, applied test unit that has performed >1000 procedures at our institution. For test, radiochromic film was first placed inside spherical phantom then irradiated sequence linearly shots equal...
Abstract Background There has been an ongoing need to compare and combine the results of new PET imaging studies conducted with [ 11 C]raclopride older data. This typically means harmonizing data across different scanners. Previous harmonization have utilized either phantoms or human subjects, but use both humans in one study is not common. The purpose herein was (1) phantom images develop inter-scanner technique (2) test subjects. Methods To (Experiment 1), Iida brain filled F-18 solution...
Immune-brain interactions influence the pathophysiology of addiction. Lipopolysaccharide (LPS)-induced systemic inflammation produces effects on reward-related brain regions and dopamine system. We previously showed that LPS amplifies elevation induced by methylphenidate (MP), compared to placebo (PBO), in eight healthy controls. However, system tobacco smokers have not been explored. The goal Study 1 was replicate previous findings an independent cohort smokers. 2 combine with...
<title>Abstract</title> <bold>Purpose</bold> To assess alterations in H3R availability with age and body mass index (BMI) healthy humans using <italic>in vivo</italic> [<sup>11</sup>C]GSK189254 positron emission tomography (PET) imaging. <bold>Procedure:</bold> Twenty-four individuals (2 females, 22 males; range 20–47 years) were scanned [<sup>11</sup>C] GSK189254. Regional <italic>V</italic><sub><italic>T</italic></sub> (volume of distribution) values computed the two-tissue compartment...
Parkinson disease (PD) is the second most common neurodegenerative disease, affecting approximately 1% of world's population. Increasing evidence suggests that aerobic physical exercise can be beneficial in mitigating both motor and nonmotor symptoms disease. In a recent pilot study role on PD, we sought to confirm intensity by monitoring heart rate (HR). For this purpose, asked participants wear chest strap HR monitor (Polar Electro Oy) Fitbit Charge 4 (Fitbit Inc) wrist-worn as potential...
Drug occupancy studies with positron emission tomography imaging are used routinely in early phase drug development trials. Recently, our group introduced the Lassen Plot Filter, an extended version of standard plot to estimate voxel-level images. Occupancy images can be create EC50 image by applying Emax model at each voxel. Our goal was apply functional clustering via a algorithm and produce more precise while maintaining accuracy. A digital brain phantom 10 (corresponding different plasma...
<sec> <title>BACKGROUND</title> Parkinson disease (PD) is the second most common neurodegenerative disease, affecting approximately 1% of world’s population. Increasing evidence suggests that aerobic physical exercise can be beneficial in mitigating both motor and nonmotor symptoms disease. In a recent pilot study role on PD, we sought to confirm intensity by monitoring heart rate (HR). For this purpose, asked participants wear chest strap HR monitor (Polar Electro Oy) Fitbit Charge 4...